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Korean J Crit Care Med > Volume 20(2); 2005 > Article
Korean Journal of Critical Care Medicine 2005;20(2): 121-130.
원저 : 가토에서 Sevoflurane, Isoflurane, Enflurane이 일시적 경동맥 차단 후 국소뇌혈류에 미치는 영향
주형근, 김해규
부산대학교 의과대학 마취통증의학교실
The Changes of Regional Cerebral Blood Flow according to Inhalational Anesthetic Agents after Transient Bilateral Carotid Artery Occlusion in the Rabbit
Hyeong Geun Joo, Hae Kyu Kim
Department of Anesthesia and Pain Medicine, College of Medicine, Pusan National University, Busan, Korea. hakykim@pusan.ac.kr
BACKGROUND: Cerebral hyperperfusion syndrome is a recognized complication of carotid endarterectomy, with a reported incidence of 0.3 to 1.2%. Monitoring of regional cerebral blood flow (rCBF) may limit neurological damage. This study was planned to investigate the changes of rCBF according to inhalational anesthetic agents. METHODS: 2.40+/-0.04 kg weighed New Zealand White Rabbits were undergone transient brain ischemia by bilateral carotid artery ligation for 20 minutes. The rCBF was measured by Bowman Perfusion Monitor. RESULTS: The value of rCBF in pre-ligation state was not significantly different among the three groups. rCBF in sevoflurane group was decreased to 46% of baseline value during ischemia and increased to 143% just after reperfusion. rCBFs in isoflurane and enflurane groups were abruptly increased instead of decrease like sevoflurane group. The values of rCBF was more increasing after reperfusion in isoflurane and enflurane groups. rCBFs in all groups were return to baseline value 10 minutes after reperfusion. CONCLUSIONS: This results was suggested that sevoflurane might be contributed to create a neurologic damage during ischemia and the hyperperfusion was seen in all three anesthetic agents. The clinical investigation may be needed to establish the value of this experiment.
Key Words: Cerebral blood flow; Ischemia; Neurologic damage; Sevoflurane
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