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Korean J Crit Care Med > Volume 27(1); 2012 > Article
Korean Journal of Critical Care Medicine 2012;27(1): 1-4. doi: https://doi.org/10.4266/kjccm.2012.27.1.1
수혈 관련 급성 폐손상
제주대학교 의학전문대학 내과학교실
Transfusion-related Acute Lung Injury
Miok Kim
Department of Internal Medicine, Jeju National Medical School, Jeju, Korea. miohkim@jejunu.ac.kr
Transfusion-related acute lung injury (TRALI) is a significant cause of iatrogenic injuries in patients. It is also the major cause of transfusion-associated fatalities. Pathophysiologic mechanism is an implicated donor of HLA. Neutrophil antibodies and biologic response modifiers are accumulated in the stored blood products. Pulmonary endothelial activation of the host may be the response from these mediators. Treatment is supportive and will be subjected to other forms of ALL/ARDS. Diverting donors at high risk for alloimmunization may decrease the incidence of such cases.
Key Words: acute lung injury; blood transfusion
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