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Original Article
- Infection
- Nosocomial meningitis in intensive care: a 10-year retrospective study and literature review
- Sofia R. Valdoleiros, Cristina Torrão, Laura S. Freitas, Diana Mano, Celina Gonçalves, Carla Teixeira
- Acute Crit Care. 2022;37(1):61-70. Published online January 26, 2022
- DOI: https://doi.org/10.4266/acc.2021.01151
- 14,738 View
- 363 Download
- 19 Web of Science
- 22 Crossref
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Abstract
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Supplementary Material - Background
Nosocomial meningitis is a medical emergency that requires early diagnosis, prompt initiation of therapy, and frequent admission to the intensive care unit (ICU).
Methods
A retrospective study was conducted in adult patients diagnosed with nosocomial meningitis who required admission to the ICU between April 2010 and March 2020. Meningitis/ventriculitis and intracranial infection were defined according to Centers for Disease Control and Prevention guidelines.
Results
An incidence of 0.75% of nosocomial meningitis was observed among 70 patients. The mean patient age was 59 years and 34% were ≥65 years. Twenty-two percent of patients were in an immunocompromised state. A clear predisposing factor for nosocomial meningitis (traumatic brain injury, basal skull fracture, brain hemorrhage, central nervous system [CNS] invasive procedure or device) was present in 93% of patients. Fever was the most frequent clinical feature. A microbiological agent was identified in 30% of cases, of which 27% were bacteria, with a predominance of Gram-negative over Gram-positive. Complications developed in 47% of cases, 24% of patients were discharged with a Glasgow coma scale <14, and 37% died. There were no clear clinical predictors of complications. Advanced age (≥65 years old) and the presence of complications were associated with higher hospital mortality.
Conclusions
Nosocomial meningitis in critical care has a low incidence rate but high mortality and morbidity. In critical care patients with CNS-related risk factors, a high level of suspicion for meningitis is warranted, but diagnosis can be hindered by several confounding factors. -
Citations
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BMJ Case Reports.2024; 17(6): e257872. CrossRef - Glioma grade and post-neurosurgical meningitis risk
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Acta Neurochirurgica.2024;[Epub] CrossRef - Etiologies and comorbidities of meningitis deaths in children under 5 years in high-mortality settings: Insights from the CHAMPS Network in the post-pneumococcal vaccine era
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Journal of Infection.2024; 89(6): 106341. CrossRef - Decolonization of autologous blood with cefuroxime during hardware reinfusion in neurosurgical patients
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