Skip Navigation
Skip to contents

ACC : Acute and Critical Care

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
4 "Youn-Jung Kim"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Articles
Infection
Relationship between low hemoglobin levels and mortality in patients with septic shock
Sung Min Jung, Youn-Jung Kim, Seung Mok Ryoo, Won Young Kim
Acute Crit Care. 2019;34(2):141-147.   Published online May 31, 2019
DOI: https://doi.org/10.4266/acc.2019.00465
  • 16,491 View
  • 257 Download
  • 14 Web of Science
  • 17 Crossref
AbstractAbstract PDFSupplementary Material
Background
Hemoglobin levels are a critical parameter for oxygen delivery in patients with shock. On comparing target hemoglobin levels upon transfusion initiation, the correlation between the severity of decrease in hemoglobin levels and patient outcomes remains unclear. We evaluated the association between initial hemoglobin levels and mortality in patients with septic shock treated with protocol-driven resuscitation bundle therapy at an emergency department.
Methods
Data of adult patients diagnosed with septic shock between June 2012 and December 2016 were extracted from a prospectively compiled septic shock registry at a single academic medical center. Patients were classified into four groups according to initial hemoglobin levels: ≥9.0 g/dl, 8.0−8.9 g/dl, 7.0−7.9 g/dl, and <7.0 g/dl. The primary endpoint was 90-day mortality.
Results
In total, 2,265 patients (male, 58.3%; median age, 70.0 years [interquartile range, 60 to 78 years]) with septic shock were included. For the four groups, 90-day mortality rates were as follows: 29.1%, 43.0%, 46.5%, and 46.9% for ≥9.0 g/dl (n=1,808), 8.0−8.9 g/dl (n=217), 7.0−7.9 g/dl (n=135), and <7.0 g/dl (n=105), respectively (P<0.001). Multivariate logistic regression showed that initial hemoglobin levels were an independent factor associated with 90-day mortality and mortality proportionally increased with decreasing hemoglobin levels (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.36 to 2.61 for 8.0−8.9 g/dl; OR, 1.97; 95% CI, 1.31 to 2.95 for 7.0–7.9 g/dl; and OR, 2.35; 95% CI, 1.52 to 3.63 for <7.0 g/dl).
Conclusions
Low hemoglobin levels (<9.0 g/dl) were observed in approximately 20% of patients with septic shock, and the severity of decrease in these levels correlated with mortality.

Citations

Citations to this article as recorded by  
  • Prognostic value of hemoglobin in patients with sepsis: A systematic review and meta-analysis
    Jin Zhu, Yanyan Dong, Pengda Liao, Xin Yin, Jianzhuo He, Liheng Guo
    Heart & Lung.2024; 64: 93.     CrossRef
  • Acute blood loss anemia in hospitalized patients is associated with adverse outcomes: An analysis of the Nationwide Inpatient Sample
    Dhweeja Dasarathy, Amy H. Attaway
    The American Journal of the Medical Sciences.2024; 367(4): 243.     CrossRef
  • Ceftriaxone-induced severe hemolytic anemia, renal calculi, and cholecystolithiasis in a 3-year-old child: a case report and literature review
    Enfu Tao, Huangjia Zhou, Meili Zheng, Yisha Zhao, Junfen Zhou, Junhui Yuan, Tianming Yuan, Changhua Zheng
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Exploring a global interpretation mechanism for deep learning networks when predicting sepsis
    Ethan A. T. Strickler, Joshua Thomas, Johnson P. Thomas, Bruce Benjamin, Rittika Shamsuddin
    Scientific Reports.2023;[Epub]     CrossRef
  • Blood count derangements after sepsis and association with post-hospital outcomes
    Scott J. Denstaedt, Jennifer Cano, Xiao Qing Wang, John P. Donnelly, Sarah Seelye, Hallie C. Prescott
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Potential therapeutic effect of Carica papaya leaves extract on immune response, biochemical and hematological mechanisms on cecal ligation and puncture model of sepsis in rats: an in vivo study
    Juveria Usmani, Mohd Wasim, Mohd Nazam Ansari, Mohammed Jaseem Hassan, Manju Sharma, Razi Ahmad
    3 Biotech.2023;[Epub]     CrossRef
  • Mortality among adult patients with sepsis and septic shock in Korea: a systematic review and meta-analysis
    Myeong Namgung, Chiwon Ahn, Yeonkyung Park, Il-Youp Kwak, Jungguk Lee, Moonho Won
    Clinical and Experimental Emergency Medicine.2023; 10(2): 157.     CrossRef
  • Predictive Rule for Mortality of Inpatients With Escherichia coli Bacteremia: Chi-Square Automatic Interaction Detector Decision Tree Analysis Model
    Yudai Nakanishi, Sayato Fukui, Akihiro Inui, Daiki Kobayashi, Mizue Saita, Toshio Naito
    Cureus.2023;[Epub]     CrossRef
  • A Predictive Rule for COVID-19 Pneumonia Among COVID-19 Patients: A Classification and Regression Tree (CART) Analysis Model
    Sayato Fukui, Akihiro Inui, Takayuki Komatsu, Kanako Ogura, Yutaka Ozaki, Manabu Sugita, Mizue Saita, Daiki Kobayashi, Toshio Naito
    Cureus.2023;[Epub]     CrossRef
  • Applying artificial neural network in predicting sepsis mortality in the emergency department based on clinical features and complete blood count parameters
    Beata Pui Kwan Wong, Rex Pui Kin Lam, Carrie Yuen Ting Ip, Ho Ching Chan, Lingyun Zhao, Michael Chun Kai Lau, Tat Chi Tsang, Matthew Sik Hon Tsui, Timothy Hudson Rainer
    Scientific Reports.2023;[Epub]     CrossRef
  • Preexisting Clinical Frailty Is Associated With Worse Clinical Outcomes in Patients With Sepsis*
    Hong Yeul Lee, Jinwoo Lee, Yoon Sun Jung, Woon Yong Kwon, Dong Kyu Oh, Mi Hyeon Park, Chae-Man Lim, Sang-Min Lee
    Critical Care Medicine.2022; 50(5): 780.     CrossRef
  • Clinical assessment of neutrophil gelatinase-associated lipocalin as a potential diagnostic marker for neonatal sepsis: a prospective cohort study
    Dina Midan, Fady El-Gendy, Dalia Abo ELAlla, Mayada Kotb
    Annals of Medicine.2022; 54(1): 1725.     CrossRef
  • A Decrease in Hb and Hypoproteinemia: Possible Predictors of Complications in Neonates with Late-Onset Sepsis in a Developing Country
    Na Cai, Wei Liao, Zhiqiang Chen, Min Tao, Sheng Chen
    International Journal of General Medicine.2022; Volume 15: 6583.     CrossRef
  • Impact of 1-Hour Bundle Achievement in Septic Shock
    Byuk Sung Ko, Sung-Hyuk Choi, Tae Gun Shin, Kyuseok Kim, You Hwan Jo, Seung Mok Ryoo, Yoo Seok Park, Woon Yong Kwon, Han Sung Choi, Sung Phil Chung, Gil Joon Suh, Hyunggoo Kang, Tae Ho Lim, Donghee Son, Won Young Kim
    Journal of Clinical Medicine.2021; 10(3): 527.     CrossRef
  • The Effect of Haematocrit on Measurement of the Mid-Infrared Refractive Index of Plasma in Whole Blood
    David J. Rowe, Daniel R. Owens, Suzanne L. Parker, Saul N. Faust, James S. Wilkinson, Goran Z. Mashanovich
    Biosensors.2021; 11(11): 417.     CrossRef
  • Early Hemoglobin Status as a Predictor of Long-Term Mortality for Sepsis Patients in Intensive Care Units
    Desheng Qi, Milin Peng
    Shock.2021; 55(2): 215.     CrossRef
  • Immature granulocyte and mean platelet volume as a predictor of 30-day postoperative mortality in patients with sepsis caused by peritonitis
    RudiHartono Sinaga, Arie Utariani, Puspa Wardhani, Hardiono Hardiono
    Bali Journal of Anesthesiology.2020; 4(4): 166.     CrossRef
CPR/Resuscitation
Utility of the early lactate area score as a prognostic marker for septic shock patients in the emergency department
Gina Yu, Seung Joon Yoo, Sang-Hun Lee, June Sung Kim, Sungmin Jung, Youn-Jung Kim, Won Young Kim, Seung Mok Ryoo
Acute Crit Care. 2019;34(2):126-132.   Published online April 12, 2019
DOI: https://doi.org/10.4266/acc.2018.00283
  • 16,697 View
  • 278 Download
  • 13 Web of Science
  • 15 Crossref
AbstractAbstract PDF
Background
The current Surviving Sepsis Campaign guidelines recommend the remeasurement of lactate levels if the initial lactate level is elevated; however, the prognostic value of lactate kinetics is limited and inconsistent. We attempted to determine the efficacy of the lactate area score (calculated from repeated lactate measurements during initial resuscitation) as a prognostic marker of septic shock in the emergency department (ED).
Methods
We performed a retrospective study of adult patients with septic shock in the ED of a single tertiary medical center. Serial lactate levels were measured five times within 12 hours. We also compared the initial lactate level, maximum lactate level, and lactate area score. The lactate area score was defined as the sum of the area under the curve measured at 2, 4, 6, and 12 hours following the initial measurement.
Results
A total of 362 patients were enrolled in this study, and the overall 28-day mortality was 31.8%. The lactate area score of serial lactate levels as well as the initial (median [interquartile range], 4.9 [3.4 to 10.5]; P=0.003) and maximum (7.3 [4.2 to 13.2]; P<0.001) lactate levels were significantly higher in the non-survivor group. However, in multivariate analysis, only the lactate area score (odds ratio, 1.013; 95% confidence interval, 1.007 to 1.019) was significantly associated with 28-day mortality.
Conclusions
The early lactate area score may be a possible prognostic marker for predicting the 28-day mortality of adult septic shock patients. Further prospective interventional studies should be conducted to validate our results.

Citations

Citations to this article as recorded by  
  • Association between normalized lactate load and in-hospital mortality in patients with acute myocardial infarction
    Yue Wu, Nannan Huang, Tienan Sun, Biyang Zhang, Shiyu Zhang, Pengyu Zhang, Chunxia Zhang
    International Journal of Cardiology.2024; 399: 131658.     CrossRef
  • Electrochemical Detection of Biomarkers Via Affinity Binding with Functionalized Nanocomposite for Assessment of Tissue-Perfusion
    Ariadna Schuck, Minhee Kang, Yong-Sang Kim
    Journal of Electrical Engineering & Technology.2024;[Epub]     CrossRef
  • Role of lactate level in predicting admission need to intensive care unit and short term outcomes in patients with acute gastrointestinal bleeding
    Hekmat Nashat Shawky, Hala Mostafa Kamel, Zain Elabdeen Ahmed Sayed, Hossam Mahmoud Abdelwahab
    The Egyptian Journal of Internal Medicine.2024;[Epub]     CrossRef
  • Hierarchical Capability in Distinguishing Severities of Sepsis via Serum Lactate: A Network Meta-Analysis
    Binlu Zhu, Ruixi Zhou, Jiangwei Qin, Yifei Li
    Biomedicines.2024; 12(2): 447.     CrossRef
  • Serial evaluation of the serum lactate level with the SOFA score to predict mortality in patients with sepsis
    Heemoon Park, Jinwoo Lee, Dong Kyu Oh, Mi Hyeon Park, Chae-Man Lim, Sang-Min Lee, Hong Yeul Lee
    Scientific Reports.2023;[Epub]     CrossRef
  • Using time-course as an essential factor to accurately predict sepsis-associated mortality among patients with suspected sepsis
    Shih-Chieh Yen, Chin-Chieh Wu, Yi-Ju Tseng, Chih-Huang Li, Kuan-Fu Chen
    Biomedical Journal.2023; : 100632.     CrossRef
  • Increased normalized lactate load is associated with higher mortality in both sepsis and non-sepsis patients: an analysis of the MIMIC-IV database
    Han Chen, Shu-Rong Gong, Rong-Guo Yu
    BMC Anesthesiology.2022;[Epub]     CrossRef
  • An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid
    Farshad Tehrani, Hazhir Teymourian, Brian Wuerstle, Jonathan Kavner, Ravi Patel, Allison Furmidge, Reza Aghavali, Hamed Hosseini-Toudeshki, Christopher Brown, Fangyu Zhang, Kuldeep Mahato, Zhengxing Li, Abbas Barfidokht, Lu Yin, Paul Warren, Nickey Huang,
    Nature Biomedical Engineering.2022; 6(11): 1214.     CrossRef
  • Association between normalized lactate load and mortality in patients with septic shock: an analysis of the MIMIC-III database
    Han Chen, Shu-Rong Gong, Rong-Guo Yu
    BMC Anesthesiology.2021;[Epub]     CrossRef
  • Mortality prediction using a novel combination of biomarkers in the first day of sepsis in intensive care units
    Junkun Liu, Chengwen Bai, Binbin Li, Aijun Shan, Fei Shi, Can Yao, Yu Zhang, Jin Wang, Weibu Chen, Manying Xie, Dehui Deng
    Scientific Reports.2021;[Epub]     CrossRef
  • A Graphene-Based Enzymatic Biosensor Using a Common-Gate Field-Effect Transistor for L-Lactic Acid Detection in Blood Plasma Samples
    Ariadna Schuck, Hyo Eun Kim, Júlia Konzen Moreira, Priscila Schmidt Lora, Yong-Sang Kim
    Sensors.2021; 21(5): 1852.     CrossRef
  • Usefulness of presepsin in predicting the prognosis of patients with sepsis or septic shock: a retrospective cohort study
    Jeong Suk Koh, Yoon Joo Kim, Da Hyun Kang, Jeong Eun Lee, Song-I Lee
    Yeungnam University Journal of Medicine.2021; 38(4): 318.     CrossRef
  • Non-enzymatic lactic acid sensor based on AuPtNPs functionalized MoS2 nanosheet as electrode modified materials
    Haolin Xiao, Liangli Cao, Huishan Qin, Shanshan Wei, Miao Gu, Feijun Zhao, Zhencheng Chen
    Journal of Electroanalytical Chemistry.2021; 903: 115806.     CrossRef
  • Early lactate area scores and serial blood lactate levels as prognostic markers for patients with septic shock: a systematic review
    Rozita Khodashahi, Soroush Sarjamee
    Infectious Diseases.2020; 52(7): 451.     CrossRef
  • Recent lactate findings: is repeated serum lactate testing necessary in septic shock patients?
    Moo Suk Park
    Acute and Critical Care.2019; 34(2): 155.     CrossRef
Case Report
Cardiology
Acute fulminant myocarditis following influenza vaccination requiring extracorporeal membrane oxygenation
Youn-Jung Kim, Jun-Il Bae, Seung Mok Ryoo, Won Young Kim
Acute Crit Care. 2019;34(2):165-169.   Published online November 7, 2018
DOI: https://doi.org/10.4266/acc.2017.00045
  • 10,303 View
  • 194 Download
  • 24 Web of Science
  • 26 Crossref
AbstractAbstract PDF
The inactivated influenza vaccination is generally safe with mostly mild side effects. We report a rare but fatal adverse event following influenza vaccination. A previously healthy 27-yearold woman who received the influenza vaccination 3 days before presenting to the emergency department had rapidly aggravating dyspnea and mental deterioration. She was diagnosed as having acute fulminant myocarditis with refractory cardiogenic shock, which was successfully managed with veno-arterial extracorporeal membrane oxygenation. The cardiac function of the patient recovered in 3 weeks.

Citations

Citations to this article as recorded by  
  • Active surveillance for adverse events of influenza vaccine safety in elderly cancer patients using self-controlled tree-temporal scan statistic analysis
    Na-Young Jeong, Chung-Jong Kim, Sang Min Park, Ye-Jee Kim, Joongyub Lee, Nam-Kyong Choi
    Scientific Reports.2023;[Epub]     CrossRef
  • The Incidence of Myocarditis Following an Influenza Vaccination: A Population-Based Observational Study
    Wen-Hwa Wang, Kai-Che Wei, Yu-Tung Huang, Kuang-Hua Huang, Tung-Han Tsai, Yu-Chia Chang
    Drugs & Aging.2023; 40(2): 145.     CrossRef
  • Comparison of COVID-19 Vaccine-Associated Myocarditis and Viral Myocarditis Pathology
    Kamron Reza Hamedi, Gannett Loftus, Lawson Traylor, Richard Goodwin, Sergio Arce
    Vaccines.2023; 11(2): 362.     CrossRef
  • Myocarditis and autoimmunity
    Akira Matsumori
    Expert Review of Cardiovascular Therapy.2023; 21(6): 437.     CrossRef
  • Cardiovascular magnetic resonance (CMR) and positron emission tomography (PET) imaging in the diagnosis and follow-up of patients with acute myocarditis and chronic inflammatory cardiomyopathy
    Federico Caobelli, Jordi Broncano Cabrero, Nicola Galea, Philip Haaf, Christian Loewe, Julian A. Luetkens, Giuseppe Muscogiuri, Marco Francone
    The International Journal of Cardiovascular Imaging.2023; 39(11): 2221.     CrossRef
  • Clinical Syndromes Related to SARS-CoV-2 Infection and Vaccination in Pediatric Age: A Narrative Review
    Maria Vincenza Mastrolia, Camilla De Cillia, Michela Orlandi, Sarah Abu-Rumeileh, Ilaria Maccora, Valerio Maniscalco, Edoardo Marrani, Ilaria Pagnini, Gabriele Simonini
    Medicina.2023; 59(11): 2027.     CrossRef
  • Acute Lymphocyte Myocarditis Associated with Influenza Vaccination
    Ryo Nakamura, Shin-ichi Ando, Seiya Kato, Toshiaki Kadokami
    Internal Medicine.2022; 61(15): 2307.     CrossRef
  • Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults: Suspected Myocarditis After COVID-19 Vaccination
    Dongngan T. Truong, Audrey Dionne, Juan Carlos Muniz, Kimberly E. McHugh, Michael A. Portman, Linda M. Lambert, Deepika Thacker, Matthew D. Elias, Jennifer S. Li, Olga H. Toro-Salazar, Brett R. Anderson, Andrew M. Atz, C. Monique Bohun, M. Jay Campbell, M
    Circulation.2022; 145(5): 345.     CrossRef
  • Myocarditis following rAd26 and rAd5 vector‐based COVID‐19 vaccine: case report
    Farah Naghashzadeh, Shadi Shafaghi, Atosa Dorudinia, Seyed Alireza Naji, Majid Marjani, Ahmad Amin, Arezoo Mohamadifar, Sima Noorali, Babak Sharif Kashani
    ESC Heart Failure.2022; 9(2): 1483.     CrossRef
  • Myocarditis following COVID-19 vaccination in adolescents and adults: a cumulative experience of 2021
    Onyedika J. Ilonze, Maya E. Guglin
    Heart Failure Reviews.2022; 27(6): 2033.     CrossRef
  • Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series
    Da-Eun Roh, Hyejin Na, Jung-Eun Kwon, Insu Choi, Yeo-Hyang Kim, Hwa-Jin Cho
    Children.2022; 9(5): 693.     CrossRef
  • Cardiac Adverse Events after Vaccination—A Systematic Review
    Kanak Parmar, Sai Subramanyam, Gaspar Del Rio-Pertuz, Pooja Sethi, Erwin Argueta-Sosa
    Vaccines.2022; 10(5): 700.     CrossRef
  • A case of myocarditis after COVID-19 vaccination: incidental or consequential?
    Leona S. Alizadeh, Vitali Koch, Ibrahim Yel, Leon D. Grünewald, Daniel Mathies, Simon Martin, Thomas J. Vogl, Dominic Rauschning, Christian Booz
    Heliyon.2022; 8(6): e09537.     CrossRef
  • COVID-19 Vaccination and the Rate of Immune and Autoimmune Adverse Events Following Immunization: Insights From a Narrative Literature Review
    Naim Mahroum, Noy Lavine, Aviran Ohayon, Ravend Seida, Abdulkarim Alwani, Mahmoud Alrais, Magdi Zoubi, Nicola Luigi Bragazzi
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • COVID-19 vaccination and carditis in children and adolescents: a systematic review and meta-analysis
    Oscar Hou In Chou, Jonathan Mui, Cheuk To Chung, Danny Radford, Simon Ranjithkumar, Endurance Evbayekha, Ronald Nam, Levent Pay, Danish Iltaf Satti, Sebastian Garcia-Zamora, George Bazoukis, Göksel Çinier, Sharen Lee, Vassilios S. Vassiliou, Tong Liu, Gar
    Clinical Research in Cardiology.2022; 111(10): 1161.     CrossRef
  • Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990–2018
    John R. Su, Michael M. McNeil, Kerry J. Welsh, Paige L. Marquez, Carmen Ng, Ming Yan, Maria V. Cano
    Vaccine.2021; 39(5): 839.     CrossRef
  • Sipuleucel‐T associated inflammatory cardiomyopathy: a case report and observations from a large pharmacovigilance database
    Melissa Y.Y. Moey, Rahim A. Jiwani, Kotaro Takeda, Karyn Prenshaw, R. Wayne Kreeger, John Inzerillo, Darla K. Liles, C. Bogdan Marcu, Bénédicte Lebrun‐Vignes, D. Lynn Morris, Sivakumar Ardhanari, Joe‐Elie Salem
    ESC Heart Failure.2021; 8(4): 3360.     CrossRef
  • Myocarditis following COVID-19 vaccination
    Elisabeth Albert, Gerard Aurigemma, Jason Saucedo, David S. Gerson
    Radiology Case Reports.2021; 16(8): 2142.     CrossRef
  • Myocarditis and Other Cardiovascular Complications of the mRNA-Based COVID-19 Vaccines
    Mahesh K Vidula, Marietta Ambrose, Helene Glassberg, Neel Chokshi, Tiffany Chen, Victor A Ferrari, Yuchi Han
    Cureus.2021;[Epub]     CrossRef
  • Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination
    Han W. Kim, Elizabeth R. Jenista, David C. Wendell, Clerio F. Azevedo, Michael J. Campbell, Stephen N. Darty, Michele A. Parker, Raymond J. Kim
    JAMA Cardiology.2021; 6(10): 1196.     CrossRef
  • Acute myocarditis following Comirnaty vaccination in a healthy man with previous SARS-CoV-2 infection
    Anna Patrignani, Nicolò Schicchi, Francesca Calcagnoli, Elena Falchetti, Nino Ciampani, Giulio Argalia, Antonio Mariani
    Radiology Case Reports.2021; 16(11): 3321.     CrossRef
  • Myocarditis and pericarditis after vaccination for COVID‐19
    Blake Hudson, Ryan Mantooth, Matthew DeLaney
    Journal of the American College of Emergency Physicians Open.2021;[Epub]     CrossRef
  • Myocarditis, Pericarditis and Cardiomyopathy After COVID-19 Vaccination
    Salvatore Pepe, Ann T. Gregory, A. Robert Denniss
    Heart, Lung and Circulation.2021; 30(10): 1425.     CrossRef
  • Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children (MIS-C) Following COVID-19
    Eveline Y. Wu, M. Jay Campbell
    Current Cardiology Reports.2021;[Epub]     CrossRef
  • Hemodynamic Collapse After Influenza Vaccination: A Vaccine-Induced Fulminant Myocarditis?
    Nobutaka Nagano, Toshiyuki Yano, Yugo Fujita, Masayuki Koyama, Ryo Hasegawa, Jun Nakata, Ryo Nishikawa, Naoto Murakami, Takefumi Fujito, Atsushi Mochizuki, Hidemichi Kouzu, Atsuko Muranaka, Nobuaki Kokubu, Tetsuji Miura
    Canadian Journal of Cardiology.2020; 36(9): 1554.e5.     CrossRef
  • Fatal influenza myocarditis with incessant ventricular tachycardia
    Nidhi Saraiya, Supriya Singh, Marilou Corpuz
    BMJ Case Reports.2019; 12(7): e228201.     CrossRef
Original Article
CPR/Resuscitation
APACHE II Score Immediately after Cardiac Arrest as a Predictor of Good Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients Receiving Targeted Temperature Management
Sang-Il Kim, Youn-Jung Kim, You-Jin Lee, Seung Mok Ryoo, Chang Hwan Sohn, Dong Woo Seo, Yoon-Seon Lee, Jae Ho Lee, Kyoung Soo Lim, Won Young Kim
Acute Crit Care. 2018;33(2):83-88.   Published online May 31, 2018
DOI: https://doi.org/10.4266/acc.2017.00514
  • 6,204 View
  • 98 Download
  • 5 Web of Science
  • 4 Crossref
AbstractAbstract PDF
Background
This study assessed the association between the initial Acute Physiology and Chronic Health Evaluation (APACHE) II score and good neurological outcome in comatose survivors of out-of-hospital cardiac arrest who received targeted temperature management (TTM).
Methods
Data from survivors of cardiac arrest who received TTM between January 2011 and June 2016 were retrospectively analyzed. The initial APACHE II score was determined using the data immediately collected after return of spontaneous circulation rather than within 24 hours after being admitted to the intensive care unit. Good neurological outcome, defined as Cerebral Performance Category 1 or 2 on day 28, was the primary outcome of this study.
Results
Among 143 survivors of cardiac arrest who received TTM, 62 (43.4%) survived, and 34 (23.8%) exhibited good neurological outcome on day 28. The initial APACHE II score was significantly lower in the patients with good neurological outcome than in those with poor neurological outcome (23.71 ± 4.39 vs. 27.62 ± 6.16, P = 0.001). The predictive ability of the initial APACHE II score for good neurological outcome, assessed using the area under the receiver operating characteristic curve, was 0.697 (95% confidence interval [CI], 0.599 to 0.795; P = 0.001). The initial APACHE II score was associated with good neurological outcome after adjusting for confounders (odds ratio, 0.878; 95% CI, 0.792 to 0.974; P = 0.014).
Conclusions
In the present study, the APACHE II score calculated in the immediate post-cardiac arrest period was associated with good neurological outcome. The initial APACHE II score might be useful for early identification of good neurological outcome.

Citations

Citations to this article as recorded by  
  • Prediction performance of scoring systems after out-of-hospital cardiac arrest: A systematic review and meta-analysis
    Boldizsár Kiss, Rita Nagy, Tamás Kói, Andrea Harnos, István Ferenc Édes, Pál Ábrahám, Henriette Mészáros, Péter Hegyi, Endre Zima, Jignesh K. Patel
    PLOS ONE.2024; 19(2): e0293704.     CrossRef
  • Predicting the survivals and favorable neurologic outcomes after targeted temperature management by artificial neural networks
    Wei-Ting Chiu, Chen-Chih Chung, Chien-Hua Huang, Yu-san Chien, Chih-Hsin Hsu, Cheng-Hsueh Wu, Chen-Hsu Wang, Hung-Wen Chiu, Lung Chan
    Journal of the Formosan Medical Association.2022; 121(2): 490.     CrossRef
  • Artificial neural network-boosted Cardiac Arrest Survival Post-Resuscitation In-hospital (CASPRI) score accurately predicts outcome in cardiac arrest patients treated with targeted temperature management
    Szu-Yi Chou, Oluwaseun Adebayo Bamodu, Wei-Ting Chiu, Chien-Tai Hong, Lung Chan, Chen-Chih Chung
    Scientific Reports.2022;[Epub]     CrossRef
  • Novel Approaches to Risk Stratification of In-Hospital Cardiac Arrest
    Jason J. Yang, Xiao Hu, Noel G. Boyle, Duc H. Do
    Current Cardiovascular Risk Reports.2021;[Epub]     CrossRef

ACC : Acute and Critical Care