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Case Report
Pulmonary
Central extracorporeal membrane oxygenation and early rehabilitation for persistent severe pulmonary hypertension following pulmonary endarterectomy
Gil Myeong Seong1orcid, Sang-Bum Hong1orcid, Jin Won Huh1orcid, Chae-Man Lim1orcid, Younsuck Koh1orcid, Jae Won Lee2,3orcid, Sung-Ho Jung2orcid, Duck-Woo Park3,4orcid, Jae Seung Lee1,3orcid
Acute and Critical Care 2018;34(2):158-164.
DOI: https://doi.org/10.4266/acc.2016.01032
Published online: November 7, 2018

1Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

2Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

3Center for Pulmonary Hypertension and Venous Thrombosis, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

4Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Corresponding author Jae Seung Lee Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: +82-2-3010-3394 Fax: +82-2-2045-4039 E-mail: jsdoc1186@daum.net
• Received: December 29, 2016   • Revised: September 22, 2017   • Accepted: September 26, 2017

Copyright © 2019 The Korean Society of Critical Care Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Chronic thromboembolic pulmonary hypertension is potentially curable with a pulmonary endarterectomy. However, approximately 20% of patients have persistent pulmonary hypertension after pulmonary endarterectomy, which is a major risk factor for postoperative death. Here, we report a 34-year-old woman who suffered persistent severe pulmonary hypertension following a successful pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. Extracorporeal membrane oxygenation (ECMO) and atrial septostomy were successfully performed as rescue treatments, and active rehabilitation during ECMO was prescribed to facilitate recovery.
Pulmonary endarterectomy (PEA) is the current treatment of choice for chronic thromboembolic pulmonary hypertension (CTEPH) [1]. A successful operation markedly improves patient symptoms, and functional status and the hemodynamics of the pulmonary vasculature and right ventricle [2]. Despite the favorable long-term prognosis of PEA, there are specific perioperative complications, such as persistent pulmonary hypertension (PH) and reperfusion lung injury, that account for the majority of deaths [3,4]. Moreover, some patients experience a pulmonary hypertensive crisis immediately following endarterectomy, making it very difficult to wean them off cardiopulmonary bypass (CPB). For such complex cases, venoarterial extracorporeal membrane oxygenation (VA-ECMO) support is the only effective treatment option for recovery. We present a difficult case of CTEPH with antiphospholipid syndrome wherein VA-ECMO and atrial septostomy were used as salvage therapies during early PEA failure. This case demonstrates the life-threatening nature of post-PEA complications and provides an effective solution.
A 34-year-old woman was referred to Asan Medical Center for pulmonary hypertension for further evaluation. Approximately 15 years prior, she had been diagnosed with pulmonary thromboembolism, systemic lupus erythematosus, and antiphospholipid syndrome. Despite anticoagulant treatment with warfarin, she developed CTEPH and was placed on the waitlist for a heartlung transplantation, which she was on for 2 years. Two months before admission, she was treated for community-acquired pneumonia. After recovering, she gained 5 kg and presented with World Health Organization functional class IV symptoms. She had no active systemic lupus erythematosus-related symptoms but did have a history of hypothyroidism. Her medications included sildenafil, bosentan, furosemide, spironolactone, warfarin, digoxin, hydroxychloroquine, and levothyroxine. On examination, her vitals were as follows: blood pressure, 104/70 mmHg; pulse, 99 beats/min; temperature, 36.9˚C; respiratory rate, 22 breaths/min; and oxygen saturation while breathing ambient air, 83%.
The majority of routine laboratory test results were within the normal range, except for the following: prothrombin time, 1.68 international normalized ratio (INR; reference range, 0.8 to 1.3 INR); brain natriuretic peptide level, 564 pg/mL (reference range, 0 to 100 pg/mL); and N-terminal pro-brain natriuretic peptide level, 4,108 pg/mL (reference range, 0 to 100 pg/mL). Chest radiography revealed severe cardiomegaly and enlarged pulmonary arteries (Figure 1). Chest computed tomography revealed a severely enlarged pulmonary trunk and central pulmonary arteries with multiple wall calcifications and large organized thrombi in the right interlobar, right lower lobar, and left upper lobar branches (Figure 2A). Lung ventilation/perfusion scan showed multiple mismatched perfusion defects in both lobes (Figure 2B). Transthoracic echocardiography revealed a severe right ventricular dysfunction with a thickened ventricular free wall and peak tricuspid regurgitant velocity of 5.0 m/s. Her 6-minute walk distance was 220 m. Right heart catheterization (RHC) with pulmonary angiography showed a mean pulmonary arterial pressure (PAP) of 78 mmHg (96/65), cardiac index of 2.27 L/min/m2, pulmonary artery wedge pressure of 5 mmHg, pulmonary vascular resistance of 25.97 wood units, and mean right atrial pressure of 13 mmHg, which were confirmatory for CTEPH.
Thus, the patient was diagnosed as having very severe PH with advanced right ventricular failure and worsening symptoms. The Pulmonary Hypertension Team comprising a pulmonologist, cardiologist, and thoracic surgeon determined the patient to be eligible for PEA before lung transplantation because lung transplantation is the only potential treatment option for patients with CTEPH who are either inoperable or who experienced treatment failure with PEA. Furthermore, donor availability is generally limited, especially for heart-lung transplantation.
Bilateral PEA was performed with the patient under deep hypothermia (25˚C) and circulatory arrest [5]. After median sternotomy, the ascending aorta and both vena cava were cannulated, and CPB was initiated. The patient was cooled, and a left atrial vent was placed through the right upper pulmonary vein. The thickened intima and old organized thrombi were removed from both the lobar and segmental arteries via main and right pulmonary artery incisions (Figure 3). The total duration of circulatory arrest was 29 minutes. After being weaned off CPB, the patient was hemodynamically unstable and hypoxemic. Despite an apparently successful endarterectomy, systolic PAP was suprasystemic at 100 mmHg. CPB was resumed, and an atrial septal defect was created to decompress the right heart; however, the weaning trials failed again. Consequently, 14F arterial and 24F venous catheters were inserted into the right femoral vessels, and VA-ECMO was initiated using a Rotaflow centrifugal pump with a Quadrox-D oxygenator (MAQUET Cardiopulmonary AG, Hirrlingen, Germany). Afterward, the patient was transferred to the intensive care unit. Vasoactive drugs (i.e., norepinephrine, epinephrine, and milrinone) and inhaled nitric oxide were administered to improve her hemodynamic status.
In the intensive care unit, intravenous unfractionated heparin was initiated 4 hours after surgery, and a negative fluid balance was maintained. Although it was difficult to wean the patient off ECMO support, a second RHC was performed on postoperative day (POD) 6. Pulmonary angiography revealed extensive reobstructions of both pulmonary arteries by acute thrombi (Figure 4), and her mean PAP remained extremely high (73 mmHg). Thus, we prepared other long-term treatment options, including lung transplantation and the following: (1) ECMO mode was changed to the central type using the right atrium and ascending aorta for early mobilization and active rehabilitation; (2) we attempted to use a relatively high heparin dose to maintain an activated partial thromboplastin time of 70–90 seconds and an anti-factor Xa>0.3 IU/mL (therapeutic range, 0.3 to 0.7 IU/mL) because of recurrent thrombosis in the pulmonary arteries despite immediate anticoagulation therapy; and (3) medical management of residual PH was initiated with sildenafil and bosentan while maintaining a negative fluid balance.
On POD 6, the patient was cannulated after redo-sternotomy for central ECMO using a 20F-angled arterial cannula in the ascending aorta and a 28F-angled venous cannula in the right atrium. The sternum was closed, and cannulas were tunneled in the subxiphoid position (Figure 5).
Active rehabilitation was performed 2–3 times/day by physical therapists, intensive care physicians, respiratory therapists, or nurses. One day after central ECMO support was performed (POD 7); the patient was able to independently sit on the edge of the bed with ECMO and mechanical ventilator support; and eventually she was able to stand without support and march in place. After these improvements, all vasoactive drugs were discontinued, and extubation was successfully performed on POD 11. After extubation, she was able to ambulate independently with only ECMO support.
On POD 14, she was hemodynamically stable, with only 20% of cardiac index support performed by ECMO. Follow-up echocardiography revealed a somewhat decreased right ventricle size and peak tricuspid regurgitant velocity. At this point, the Pulmonary Hypertension Team decided to discontinue ECMO support and medically treat the patient rather than perform lung transplantation. The central ECMO support was eventually discontinued under general anesthesia with intubation on POD 14, and she was successfully weaned off the mechanical ventilator on POD 22. Subsequently, the patient was transferred to the general ward, and oral anticoagulant and diuretic doses were carefully titrated. On POD 43, she was finally discharged with a prescription of long-term oxygen therapy and a plan to undergo balloon pulmonary angioplasty.
Approximately 3 months after her operation, the patient was deemed to be World Health Organization functional class II. Her follow-up RHC revealed total occlusion of the right upper trunk and both multiple segmental arteries; she had a mean PAP of 50 mmHg and pulmonary vascular resistance of 9.5 wood units. The patient can tolerate her current medical treatments, and additional intervention will be determined during regular follow-up.
Written informed consent was obtained from the patient for publication of this case report and accompanying images.
Herein, we report a case of severe residual PH following successful PEA. In CTEPH cases, pulmonary hypertension results from both persistent macrovascular obstruction and small-vessel arteriopathy and neurohumoral factors that mediate vasoconstriction. According to a recent prospective cohort study [4], postoperative residual PH was observed in 15%–18% of patients and was associated with increased mortality (hazard ratio, 3.66; P=0.0008). However, neither the incidence nor the outcome of early PEA failure has been reported to date.
For these difficult situations, postoperative ECMO is essential and recommended as a standard of care in pulmonary hypertension centers. According to previous retrospective studies [6,7], approximately 4%–20% of patients required postoperative extracorporeal life support. Atrial septostomy was traditionally used as an effective palliative treatment for right heart failure in severe PH cases. Although many effective targeted therapies for PH have since been developed, atrial septostomy still plays a partial role for immediate [8] and long-term outcomes [9].
Our patient had CTEPH with autoimmune thrombophilia. Following early failure of PEA, salvage atrial septostomy failed to wean the patient off CPB, and VAECMO was necessary. Moreover, follow-up RHC revealed recurrent extensive thrombosis in both pulmonary arteries. In this situation, the two major treatment options were lung transplantation or medical treatment, including balloon pulmonary angioplasty. Lung transplantation was considered the inferior option for the following reasons: (1) the patient was young, and the 5-year survival rate is only approximately 50% following transplantation [10], which, in her case, would be worse considering her thrombogenic and postoperative condition, which requires extracorporeal life support [7,11,12]; (2) she was returning to a good performance state through early rehabilitation with central-type ECMO support; and (3) there would be additional opportunities to modify her medication or perform balloon angioplasty after resolving acute thrombi. Sequential pulmonary balloon angioplasty for distal arteries has been recently used for selected inoperable CTEPH patients or patients with residual or recurrent PH after successful PEA [13-15].
Rehabilitation during VA-ECMO is challenging. Most techniques rely on femoral cannulation, thereby immobilizing patients, which in turn can lead to rapid deconditioning [16]. ECMO using the aorta or upper-extremity arteries can liberate both legs and allow the patient to undergo active physical therapy. Early mobilization is beneficial for selected patients receiving ECMO who are waiting for recovery or lung transplantation. At our center, ECMO patients are evaluated daily to assess hemodynamic and respiratory stability and suitability for rehabilitation and mobilization. The exercise protocol begins with sitting on the edge of the bed and progresses to exercises performed in the standing position; the ultimate goal is for the patient to be able to march and ambulate safely. To achieve this, the multidisciplinary team pays attention to intravenous lines, ECMO cannulas, and monitoring devices currently in place. Maintenance of adequate oxygenation and hemodynamic stability during rehabilitation, ECMO sweep gas and blood flow rates, and supplemental oxygen can all be increased as needed.
In conclusion, PEA is a curative treatment option for CTEPH but can have life-threatening postoperative complications. ECMO is an essential treatment option in this situation, and early active rehabilitation during ECMO can facilitate recovery. Considering a multidisciplinary approach for complicated patients both preoperatively and postoperatively is important.

No potential conflict of interest relevant to this article was reported.

AUTHOR CONTRIBUTIONS

Conceptualization: GMS, JSL. Data curation: GMS. Formal analysis: GMS, SBH, JSL. Visualization: GMS. Writing – original draft: GMS, JSL. Writing – review & editing: all authors.

Figure 1.
Preoperative chest radiograph shows enlargement of the main pulmonary artery and of the right and left pulmonary arteries with peripheral pruning. The heart is enlarged with a prominent right atrial contour.
acc-2016-01032f1.jpg
Figure 2.
(A) Axial contrast-enhanced chest computed tomography confirms enlargement of the main pulmonary artery (6.5 cm) and shows wall-adherent chronic thrombus with calcification in the right pulmonary artery. The image shows the dilated right atrium (10.0 cm) and right ventricular hypertrophy. (B) Lung ventilation/perfusion scan reveals multiple mismatched perfusion defects in both lobes. MAA: macro aggregated albumin; ANT: anterior; LAO: left anterior oblique; LPO: left posterior oblique; POST: posterior; RPO: right posterior oblique; RAO: right anterior oblique.
acc-2016-01032f2.jpg
Figure 3.
Specimens removed from the pulmonary arteries during pulmonary endarterectomy.
acc-2016-01032f3.jpg
Figure 4.
Postoperative pulmonary angiography reveals total occlusion (arrows) of the right (A) and left (B) basal trunks of the pulmonary artery.
acc-2016-01032f4.jpg
Figure 5.
Chest radiograph obtained after central-type conversion shows the drainage cannula in the right atrium (white arrow) and the return cannula in the ascending aorta (black arrows).
acc-2016-01032f5.jpg
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