Acute and Critical Care

Original Article

Cardiology
The incidence of phlebitis development of high concentration of continuous amiodarone infusion with in-line filter compared to the low concentration without in-line filter: a retrospective propensity score-matched analysis: Sirichai Cheewatanakornkul, Piyanai Vattanaprasan, Supattra Uppanisakorn, Rungsun Bhurayanontachai; Acute Crit Care. 2022;37(3):391-397. Published online August 5, 2022; DOI: https://doi.org/10.4266/acc.2022.00080

4,099 View
249 Download
1 Web of Science
1 Crossref

Background
Phlebitis-associated peripheral infusion of intravenous amiodarone is common in clinical practice, with an incidence between 5% and 65%. Several factors, including drug concentration, catheter size, and in-line filter used, are significantly associated with phlebitis occurrence. We performed a retrospective propensity score-matched analysis to find out whether in-line filter will reduce the incidence of amiodarone-induced phlebitis (AIP) in high concentration of amiodarone infusion compared to low concentration without in-line filter.
Methods
Clinical records of all patients who required intravenous amiodarone infusion for cardiac arrhythmias, between January 2017 to December 2019 were retrieved. The incidence of AIP was recorded and subsequently compared among high concentration (2 mg/ml) with an in-line filter and low concentration (1.5 mg/ml) infusion without an in-line filter after a 1 to 2 propensity score matched.
Results
The data indicated that among the 214 cases of amiodarone infusion collected, 28 cases used an in-line filter with high concentration while 186 cases received a low concentration of amiodarone infusion without an in-line filter. After 1:2 propensity score matching, the incidence of phlebitis in the high concentration with in-line filter group was significantly higher than the low concentration without in-line filter group (28.6% vs. 3.6%, P<0.01).
Conclusions
Despite the usage of in-line filter, the high concentration of amiodarone infusion resulted in a higher incidence of peripheral phlebitis. Central venous catheterization for a high concentration of amiodarone infusion is recommended.

Citations

Citations to this article as recorded by

The Effect of Propolis Cream on Phlebitis and Catheter-Related Bloodstream Infections: A Double-Blinded Randomised Clinical Trial
Hassan Pakdaman, Ali Khodadadizadeh, Gholamreza Bazmandegan, Hadi Hasani, Majid Kazemi
Journal of Herbal Medicine.2024; 43: 100829. CrossRef

Case Report

Amiodarone-induced Pulmonary Toxicity within a Short Period of the Initiation of Amiodarone Therapy: A Case Report: Woo Jin Jang, Hae Ri Chon, Jin Sung Jung, Seung Hyun Yoo, Kyu Han Koh, Young Min Koh, Jung Hyuk Kim; Korean J Crit Care Med. 2011;26(2):117-121.; DOI: https://doi.org/10.4266/kjccm.2011.26.2.117

2,824 View
26 Download
4 Crossref

Abstract PDF

Amiodarone is one of the most commonly prescribed antiarrhythmic drug for almost all atrial or ventricular arrythmias. Amiodarone-induced pulmonary toxicity (APT) was first described in 1980 and has potentially serious side effects that are believed to develop in 5% of patients. In general, APT occurs only when high amiodarone doses are used for a long time. However, during short-term therapy of amiodarone, APT is rarely reported. In this report, we describe a case of amiodarone-induced pulmonary toxicity after a short course of amiodarone therapy for atrial fibrillation.

Citations

Citations to this article as recorded by

A Case of Acute Hepatitis Associated with Intravenous Infusion Amiodarone in Patient with Atrial Fibrillation
Ji Hye Lee, Myug-Shin Kang, Tae-Hoon Kim, Dong Hee Shin, Rak Kyeong Choi, Su Jin Jung
Soonchunhyang Medical Science.2015; 21(2): 208. CrossRef
Amiodarone Induced Multiorgan Toxicity in a Patient of Hypertrophic Cardiomyopathy With Atrial Fibrillation
Dae Jung Kim, Sang Chil Lee, Gi Soo Park, Gyung Jung Kim, Won Tae Hwang, Chang Soo Lee, Moo Hyun Lee, Dae Hee Hahn, Hyeon Cheol Koh
Journal of the Korean Geriatrics Society.2013; 17(4): 223. CrossRef
Very Early Onset of Amiodarone-Induced Pulmonary Toxicity
Wonho Lee, Dong Rueol Ryu, Seon-Sook Han, Sook-Won Ryu, Byung Ryul Cho, Hyucki Kwon, Bo Ra Kim
Korean Circulation Journal.2013; 43(10): 699. CrossRef
Amiodarone-Induced Pulmonary Toxicity: Percutaneous Needle Aspiration Biopsy and Ultrastructural Findings
In Sook Kang, Jin Hwa Lee, Sun Hee Sung, Seong Hoon Park
The Ewha Medical Journal.2013; 36(2): 144. CrossRef

First
Prev
Page of 1
Next
Last

Search