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1 "Kyu Sun Yum"
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Review Article
Transient splenial lesions of the corpus callosum and infectious diseases
Kyu Sun Yum, Dong-Ick Shin
Acute Crit Care. 2022;37(3):269-275.   Published online August 17, 2022
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AbstractAbstract PDF
comTransient splenial lesion of the corpus callosum can be observed in various diseases such as cancer, drug use, metabolic disorders, and cerebrovascular disorders, as well as in patients with infectious diseases. During the coronavirus disease 2019 (COVID-19) pandemic, there were increasing reports of these lesions being detected on brain imaging tests performed in patients with neurological symptoms. On brain magnetic resonance imaging, findings suggestive of cytotoxic edema are observed in the splenium; these are known to disappear with improvement of clinical symptoms. Cytokinopathy caused by infection increases the permeability of the blood–brain barrier and activates the glial cells of the brain to induce cytotoxic edema. Most patients have a good prognosis. The causes, mechanism, diagnosis, treatment and prognosis of transient splenial lesions of the corpus callosum will be summarized in this review.


Citations to this article as recorded by  
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    Chung-Hao Wang, Chi-Nan Huang, Pei-Wei Wang
    Pediatrics & Neonatology.2024; 65(2): 204.     CrossRef
  • Legionella‐induced dysarthria and rhabdomyolysis with acute renal failure achieving recovery
    Husam El Sharu, Soban Ahmad, Hunter Coore
    Clinical Case Reports.2024;[Epub]     CrossRef
  • Rickettsial infection causing non-aneurysmal subarachnoid hemorrhage with transient corpus callosum lesion
    Zahraa Noureddine El Moussaoui, Zahraa Saker, Hasan Rahhal, Ali Nasserdine, Mahmoud Younes
    Journal of Medicine, Surgery, and Public Health.2024; 2: 100093.     CrossRef

ACC : Acute and Critical Care