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- Polyethylene Glycol (PEG-3350, Colyte) Poisoning due to Intra-Peritoneal Leakage in an Elderly Patient
- Jae Hee Chung, Seok Chan Kim, Jun-Gi Kim
- Korean J Crit Care Med. 2015;30(1):56-60. Published online February 28, 2015
- DOI: https://doi.org/10.4266/kjccm.2015.30.1.56
- 10,152 View
- 72 Download
- 1 Crossref
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Abstract
PDF - Polyethylene glycol (PEG)-3350 is the most frequently used lavage solution for bowel cleansing prior to colonoscopy or elective surgery because its large molecular weight means that it is poorly absorbed. However, if it leaks into the peritoneal cavity, complications may arise. Few published studies have assessed the absorption, distribution, metabolism and excretion of PEG. Moreover, no published clinical data regarding complications due to the intra-peritoneal leakage of PEG-3350 could be found. We report on an elderly patient who developed the poisoning caused by leaking of PEG-3350 during bowel preparation. It resulted in severe metabolic acidosis, hypernatremia, hyperosmolality and a high anion gap, but it was effectively treated with early continuous renal replacement therapy after surgery.
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Citations
Citations to this article as recorded by
- Severe hypernatremia and transient azotemia in a cat following inadvertent intravenous administration of a commercial polyethylene glycol solution
Sabrina N. Hoehne, Casey J. Kohen, Birgit Puschner, Ingrid Gennity, Simon P. Hagley, Kate S. Farrell, Karin Unger, Laura A. Cagle, Karl E. Jandrey
Journal of Veterinary Emergency and Critical Care.2019; 29(6): 690. CrossRef
- Severe hypernatremia and transient azotemia in a cat following inadvertent intravenous administration of a commercial polyethylene glycol solution
- A Case of Uremic Pericarditis and Cardiac Tamponade That Developed after Ethylene Glycol Poisoning: A Case Report
- Ki Ju Kim, Jung Gil Park, Han Jun Ryu, Yeoun Su Jung, Sung Ho Kim, Bong Ryeol Lee, Byung Chun Jung, Hyun Jae Kang
- Korean J Crit Care Med. 2010;25(3):176-181.
- DOI: https://doi.org/10.4266/kjccm.2010.25.3.176
- 3,003 View
- 108 Download
- 1 Crossref
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Abstract
PDF
- Ethylene glycol is commonly incorporated into automotive antifreeze agents and a variety of other commercial products. Ethylene glycol poisoning can cause life-threatening metabolic acidosis, cardiopulmonary failure, and renal failure that may be fatal. We present an unusual case of a patient who ingested a large amount of ethylene glycol for the purpose of suicide and developed multiorgan damage, including acute renal failure followed by uremic pericarditis and cardiac tamponade. This unusual complication was effectively managed with echocardiography-guided percutaneous pericardiocentesis and continuous catheter drainage for 3 days. After intensive hemodialysis and supportive care, the patient made a good recovery with near normal cardiac and renal function. Physicians should be aware of the possibility of acute pericarditis and cardiac tamponade in cases of acute renal failure caused by ethylene glycol poisoning.
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Citations
Citations to this article as recorded by- Deneysel Etilen Glikol Zehirlenmesi Oluşturulan Ratlarda Myokardiyal Etkilerin Araştırılması*,**
Burak DOĞAN, Vehbi GÜNEŞ
Erciyes Üniversitesi Veteriner Fakültesi Dergisi.2020; 17(3): 275. CrossRef
- Deneysel Etilen Glikol Zehirlenmesi Oluşturulan Ratlarda Myokardiyal Etkilerin Araştırılması*,**
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