- Pulmonary
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A Pleural Catheter Malposition through Diaphragm to Abdominal Cavity
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Won Jai Jung, Sue In Choi, Eun Joo Lee, Sang Yeub Lee, Kwang Ho In
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Korean J Crit Care Med. 2017;32(4):370-371. Published online November 30, 2017
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DOI: https://doi.org/10.4266/kjccm.2017.00290
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- The Malpositioned Tunneled Pleural Catheter
Olaedo Abana, Uzair Ghori, Ammar Alqaid, Robert Holladay Journal of Bronchology & Interventional Pulmonology.2021; 28(4): e62. CrossRef
- Infection
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Implications of Plasma Renin Activity and Plasma Aldosterone Concentration in Critically Ill Patients with Septic Shock
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Kyung Soo Chung, Joo Han Song, Won Jai Jung, Young Sam Kim, Se Kyu Kim, Joon Chang, Moo Suk Park
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Korean J Crit Care Med. 2017;32(2):142-153. Published online May 31, 2017
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DOI: https://doi.org/10.4266/kjccm.2017.00094
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8,832
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Abstract
PDFSupplementary Material
- Background
The renin-angiotensin-aldosterone system is closely associated with volume status and vascular tone in septic shock. The present study aimed to assess whether plasma renin activity (PRA) and plasma aldosterone concentration (PAC) measurements compared with conventional severity indicators are associated with mortality in patients with septic shock.
Methods We evaluated 105 patients who were admitted for septic shock. Plasma levels of the biomarkers PRA and PAC, the PAC/PRA ratio, C-reactive protein (CRP) level, and cortisol level on days 1, 3, and 7 were serially measured. During the intensive care unit stay, relevant clinical information and laboratory results were recorded.
Results Patients were divided into two groups according to 28-day mortality: survivors (n = 59) and non-survivors (n = 46). The survivor group showed lower PRA, PAC, Acute Physiologic and Chronic Health Evaluation (APACHE) II score, and Sequential Organ Failure Assessment (SOFA) score than did the non-survivor group (all P < 0.05). The SOFA score was positively correlated with PRA (r = 0.373, P < 0.001) and PAC (r = 0.316, P = 0.001). According to receiver operating characteristic analysis, the areas under the curve of PRA and PAC to predict 28-day mortality were 0.69 (95% confidence interval [CI], 0.58 to 0.79; P = 0.001) and 0.67 (95% CI, 0.56 to 0.77; P = 0.003), respectively, similar to the APACHE II scores and SOFA scores. In particular, the group with PRA value ≥3.5 ng ml-1 h-1 on day 1 showed significantly greater mortality than did the group with PRA value <3.5 ng ml-1 h-1 (log-rank test, P < 0.001). According to multivariate analysis, SOFA score (hazard ratio, 1.11; 95% CI, 1.01 to 1.22), PRA value ≥3.5 ng ml-1 h-1 (hazard ratio, 3.25; 95% CI, 1.60 to 6.60), previous history of cancer (hazard ratio, 3.44; 95% CI, 1.72 to 6.90), and coronary arterial occlusive disease (hazard ratio, 2.99; 95% CI, 1.26 to 7.08) were predictors of 28-day mortality.
Conclusions Elevated PRA is a useful biomarker to stratify the risk of critically ill patients with septic shock and is a prognostic predictor of 28-day mortality.
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Citations
Citations to this article as recorded by
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Laurence W. Busse, Christopher L. Schaich, Mark C. Chappell, Michael T. McCurdy, Erin M. Staples, Caitlin C. Ten Lohuis, Jeremiah S. Hinson, Jonathan E. Sevransky, Richard E. Rothman, David W. Wright, Greg S. Martin, Ashish K. Khanna Critical Care Medicine.2024; 52(3): 441. CrossRef - Renin as a Prognostic Marker in Intensive Care and Perioperative Settings: A Scoping Review
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Christopher L. Schaich, Daniel E. Leisman, Marcia B. Goldberg, Micheal R. Filbin, Ashish K. Khanna, Mark C. Chappell Peptides.2024; 176: 171201. CrossRef - Renin in critically ill patients
Yuki Kotani, Mark Chappell, Giovanni Landoni, Alexander Zarbock, Rinaldo Bellomo, Ashish K. Khanna Annals of Intensive Care.2024;[Epub] CrossRef - Blood urea nitrogen - independent marker of mortality in sepsis
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Maniraj Jeyaraju, Michael T. McCurdy, Andrea R. Levine, Prasad Devarajan, Michael A. Mazzeffi, Kristin E. Mullins, Michaella Reif, David N. Yim, Christopher Parrino, Allison S. Lankford, Jonathan H. Chow Critical Care Medicine.2022; 50(1): 50. CrossRef - Mechanisms of Post-critical Illness Cardiovascular Disease
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