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Korean J Crit Care Med > Volume 28(2); 2013 > Article
Korean Journal of Critical Care Medicine 2013;28(2): 93-100. doi: https://doi.org/10.4266/kjccm.2013.28.2.93
소아 중환자의 예후 인자로서 혈소판 감소증과 변화 양상의 유용성
김윤희ㆍ박현빈ㆍ김민정ㆍ김환수ㆍ이희선ㆍ한윤기ㆍ김경원ㆍ손명현ㆍ김규언
연세대학교 의과대학 소아과학교실
Usefulness of Thrombocytopenia and Changes in Platelet Counts as Prognostic Markers in Pediatric Intensive Care Units
Yoon Hee Kim, Hyun Bin Park, Min Jung Kim, Hwan Soo Kim, Hee Seon Lee, Yoon Ki Han, Kyung Won Kim, Myung Hyun Sohn, Kyu Earn Kim
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. kwkim@yuhs.ac
ABSTRACT
BACKGROUND: Thrombocytopenia has been shown to be a useful predictor of mortality in adult intensive care units (ICUs). The aim of this study is to assess whether the level of platelet count at ICU admission and the changes in platelet counts can predict mortality in the pediatric ICU (PICU). METHODS: Platelet counts were checked daily for at least 4 days in a total of 303 children who were admitted to the ICU. We compared the initial platelet counts and changes in platelet counts between survivors and non-survivors. A multivariable logistic regression model, a receiver operating characteristic curve and a linear mixed model were used. RESULTS: The initial platelet count was significantly lower in non-survivors when compared to survivors. Multivariate analysis demonstrated that platelet count <120 x 10(9)/L (Odds ratio, 4.913; 95% confidence interval 2.451-9.851; p < 0.0001) was an independent predictor of mortality. In the case of children with thrombocytopenia (<120 x 10(9)/L) at admission to the ICU, the platelet counts increased serially in survivors, whereas non-survivors maintained their decreased platelet counts. In the case of children without thrombocytopenia, the platelet counts decreased most on day 3 in non-survivors. CONCLUSIONS: At admission to the ICU, thrombocytopenia defined as a platelet count <120 x 10(9)/L can be a useful predictor of mortality in children. In children who had initial thrombocytopenia, the serial increase of platelet counts can be related to increased survival, whereas in children who did not have initial thrombocytopenia, more than a 10% decrease of platelet counts on day 3 can be related to mortality.
Key Words: child; intensive care units; platelet count; prognosis; thrombocytopenia
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