Suspected Pulmonary Embolism during Hickman Catheterization in a Child: What Else Should Be Considered besides Pulmonary Embolism?

Haemi Lee; Jonghyun Baek; Sangyoung Park; Daelim Jee

doi:10.4266/kjccm.2016.31.1.63

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Case Report Suspected Pulmonary Embolism during Hickman Catheterization in a Child: What Else Should Be Considered besides Pulmonary Embolism?: Haemi Lee, M.D., Ph.D.¹, Jonghyun Baek, M.D.², Sangyoung Park, M.D.¹, Daelim Jee, M.D., Ph.D.¹; Korean Journal of Critical Care Medicine 2016;31(1):63-67.
DOI: https://doi.org/10.4266/kjccm.2016.31.1.63
Published online: February 29, 2016

¹Department of Anesthesiology and Pain Medicine, College of Medicine, Yeungnam University, Daegu, Korea

²Department of Thoracic Surgery, College of Medicine, Yeungnam University, Daegu, Korea

Correspondence to: Haemi Lee, Department of Anesthesiology and Pain Medicine, College of Medicine, Yeungnam University, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Korea Tel: +82-53-620-3361, Fax: +82-53-525-5276 E-mail: hmlee@yu.ac.kr

• Received: December 21, 2015 • Revised: February 2, 2016 • Accepted: February 14, 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract
Case Report
Discussion
NOTES
REFERENCES

Abstract

A 16-month-old girl with acute lymphoblastic leukemia expired during Hickman catheter insertion. She had undergone chemoport insertion of the left subclavian vein six months earlier and received five cycles of chemotherapy. Due to malfunction of the chemoport and the consideration of hematopoietic stem cell transplantation, insertion of a Hickmann catheter on the right side and removal of the malfunctioning chemoport were planned under general anesthesia. The surgery was uneventful during catheter insertion, but the patient experienced the sudden onset of pulseless electrical activity just after saline was flushed through the newly inserted catheter. Cardiopulmonary resuscitation was commenced aggressively, but the patient was refractory. Migration of a thrombus generated by the previous central catheter to the pulmonary circulation was suspected, resulting in a pulmonary embolism.
Key Words: cardiopulmonary resuscitation; central venous catheters; pediatrics; pulmonary embolism

Pediatric pulmonary embolism (PE) is not as common as in adults. The annual incidence of childhood PE has been reported as 0.86/10,000 hospital admissions in Canada and 0.14-0.9/100,000 children in the Netherlands.[1,2] However, the evidence suggests that the incidence is under-recognized because of a low index of suspicion and the masking of symptoms by underlying disease in pediatric settings. Therefore, the condition is mainly diagnosed at autopsy and the mortality rate was reported to be around 10%.[1] PE originates most commonly from deep venous thrombosis (DVT) in conditions of venous stasis, endothelial damage, and hypercoagulable states. These situations are frequently induced by cancer, because chemotherapeutic agents release hormones causing hypercoagulable states, patients often experience reduced mobility and the frequent presence of a central venous catheter (CVC), or there is possible venous obstruction from the tumor itself. The presence of CVCs is the single most important risk factor for DVT in children; 94% of neonates and 37% of children 1 month to 18 years of age who have DVT has been reported to have CVCs.[2] The American College of Chest Physicians guidelines reported that at least 85% of DVTs are related to CVCs and nearly all DVT-related deaths are associated with CVCs.[3,4] Herein, we report a case in a cancer patient of suspected PE due to migration of a thrombus from a previously inserted CVC.

Case Report

A 16-month-old girl with acute lymphoblastic leukemia (8 kg/73 cm) was scheduled to undergo insertion of a Hickman catheter for chemotherapy. She had received a chemoport (Celsite^® Babyport^®4.5 Fr, B. Braun Medical, Boulogne Cedex, France) insertion six months earlier on the left subclavian vein and had a fixation two months earlier because of a rotated chemoport. Two weeks after successful treatment via indwelling chemoport on 5^th chemotherapy, the patient was admitted for the next chemotherapy and noticed that the chemoport was not functioning well. As hematopoietic stem cell transplantation was considered, removal of chemoport and insertion of Hickmann catheter were planned. She experienced no specific complications during the previous operations and recovered from the anesthesia without any problems. Her echocardiography taken after the chemoport fixation was non-specific either. She received chemotherapy with cytarabine, methotrexate, endoxan and vincristine, and-heparin and urokinase were used for anticoagulation (Table 1).

At the time of the surgery, she did not have any premedication and she was monitored with non-invasive blood pressure, electrocardiography (ECG), oxygen saturation (SpO₂), and end-tidal CO₂ (EtCO₂). Thiopental sodium 40 mg and rocuroniumbromide 5 mg were used for anesthetic induction. Intubation was commenced with an internal diameter 4.0 endotracheal tube and sevoflurane was used for anesthetic maintenance. During the insertion of the catheter, the patient had blood pressure (BP) between 90-100/45-50 mmHg, heart rate (HR) 120-130 beats/min, SpO₂ 99-100%, and EtCO₂ 33-35 mmHg. Full length of the Hickman catheter (Hickman 7 Fr. Dual Lumen CV Catheter^®, BARD, Murray Hill, New Jersey, USA) was filled with heparin mixed solution (heparin 2,000 IU in 100 mL normal saline) and fixed in the patient’s right subclavian vein. Catheter function was confirmed by free flow of regurgitation and then10 mL of heparin mixed warm saline was slowly injected through the catheter. At that time, the patient’s HR increased from 120 to 140 beats/min for a few seconds and then decreased precipitously to 50 beats/min. Simultaneously, her EtCO₂ decreased to less than 20 mmHg, and subsequently her BP and SpO₂ could not be measured. The patient’s ECG showed pulseless electrical activity (PEA) of 30-40 bpm. We immediately stopped the administration of anesthesia and started chest compressions. Epinephrine 100 mcg was injected a few times under manual bagging with 100% oxygen. Airway resistance could not be detected by manual bagging and tidal volumes were adequate. Endotracheal suction was attempted but nothing could be sucked out and pulmonary sounds were heard bilaterally on chest auscultation. The arterial blood gas analysis just after initiation of cardiopulmonary resuscitation (CPR) showed pH 7.18, PaCO₂ 106 mmHg, PaO₂ 15 mmHg, and after 30 minutes, pH<6.80, PaCO₂>115 mmHg, PaO₂ 14 mmHg under FiO₂ 1.0. Serum Na was 136 mmol/L, K 4.0 mmol/L, Ca 1.18 mmol/L, Hct 27% and blood sugar 221 mg/dL. Portable chest Xray showed no specific findings (Fig.1). Despite aggressive CPR, the patient did not recover from cardiac arrest. The parents refused autopsy.

Discussion

This case was considered to be a pulmonary thromboembolism (PTE) due to migration of a venous thrombus arising from the previous central catheter. Although many diagnostic tools failed to be applied in this case because of the sudden onset compromise, the intraoperative situation, monitoring, and laboratory findings may reflect this case as a PTE. The sudden onset of hypoxemia and bradycardia right after the saline flush at the end of the procedure might reflect the dislodging of thrombotic material adherent to the vessel wall or the previous catheter and its migration to the pulmonary arteries. The malfunctioning of a long-standing previous central catheter may reflect the possibility of thrombosis, as well. The sudden onset of PEA despite no previous cardiac or metabolic problems, a very low PaO₂ and a wide EtCO₂-PaCO₂ gap despite 100% oxygen delivery by manual bagging at the time of attack, and are fractory state despite aggressive CPR are sufficient to strongly suggest PE. As the diameter of pulmonary vessels is small in children, even a small amount of thrombus may occlude major or several peripheral pulmonary arteries with a severe hemodynamic event, thus resulting in a life-threatening complication.

Actually diagnosing PE is not easy especially in anesthetized, mechanically ventilated patients. In most cases, dyspnea and tachycardia accompany PE, but these could be masked or misread during general anesthesia. In this case, the sudden bradycardia just after the saline injection was first thought to be a reflex phenomenon, but it was not resolved by epinephrine injection. Elevated HR was noticed for a very short period, but it was in an acceptable range and this could also appear due to decreased anesthetic delivery at the end of surgery. Derish et al.[5] reported that among five patients out of 1,033 patients in the pediatric intensive care unit (PICU) who died of PE during an 18-month-period, only one patient was diagnosed ante mortem, and the rest were not diagnosed until autopsy. All of patients had CVCs and the thrombus was found in a corresponding insertion site.

CVCs are increasingly used in clinical practice. In a remarkable proportion of patients, PE is the first clinical manifestation of the silent nature of CVC-associated thrombi, and a history of CVC malfunction is not uncommon in patients with CVC-related DVT.[6] Prospective studies reveal that asymptomatic central venous line-related thrombosis occurs more frequently in children and the presence of CVCs led to a nine-fold increased risk factor of venous thromboembolism (VTE) in the PICU.[1,7-10] That isbecause flow stasis is more prominentin children because they have a higher CVC/vein ratio.[11] Left-side insertion-through thesubclavian vein is associated with an increased risk for VTE because a longer horizontal course leads to a sharper angle to the SVC, thus increasing the potential for endothelial damage.[12] A large case-control study developing a new risk score for hospital-associated VTE in noncritically ill children revealed a CVC, infection, and length of stay more than four days as significant risk factors for VTE, and of the risk factor of CVC, 94% of CVCs were located at the same location as the clot.[13]

In acute PE, markedly reduced values for EtCO₂ and as increased difference between arterial and end-tidal CO₂ measures would be observed.[14] In pulmonary arterial obstruction, the pulmonary dead space is increased and pulmonary capacity for the elimination of CO₂ is reduced.[15] In severe pulmonary arterial obstruction, cardiac output and pulmonary arterial perfusion are reduced; therefore, the pulmonary arterial supply of CO₂ is low and the alveolar CO₂ diffusion is reduced.[16] However, this phenomenon is not limited to PE only, and left-sided heart failure rather than PE itself may also cause the specific PaCO₂-EtCO₂ trend. However, in this case, the difference between arterial and end-tidal CO₂ and the difference between arterial and alveolar O₂ was too extreme even during the early period of CPR with adequate chest compressions and ventilations (Table 2). The occurrence of an unexplained shock right after the injection of the irrigating fluid may reflect the possibility of PE. This difference cannot be explained except for the abrupt cessation of pulmonary circulation.

The administration of thrombolytic therapy during CPR in adult patients had been reported to reduce the mortality, although it has classically been contraindicated.[17] It is a high risk procedure that can produce serious complications such as fatal hemorrhage. Pavlovic et al.[18] reported a case of massive PE in an adult patient, who was successfully treated with extracorporeal membrane oxygenation (ECMO). They recommended considering ECMO as a first-line therapy although current guidelines do not consider it a first-line therapy. However, undetected PE is unfortunately too common in pediatric patients and most of them were proved by autopsy, so making the decision to administer thrombolyticsor ECMO in these situations is challenging.

In conclusion, this case was considered to be a PTE due to migration of a venous thrombus generated by a previous chemoport. The choice of treatment depends on the clinical presentation, but diagnosis is often subtle or masked by the underlying clinical condition or general anesthesia during surgery. Therefore, physicians should be alert to the possibility of PE at risk, especially those with prolonged indwelling catheters. It is recommended to screen the venous system before removing or reinserting a central line although most catheter-related thrombi are asymptomatic. A combination of duplex ultrasound (US) and venography is recommended for the screening. US can be used to confirm the DVT, and patients with positive US should be treated with anticoagulant therapy. Patients with negative US may undergo venography.[6] Although there is little evidence for efficacy or safety of systemic anticoagulation to prevent CVC-related VTE in children, it is essential to precede anticoagulation therapy at least three to five days. CVC should be removed as soon as possible when it is no longer required or is not functioning.

NOTES

No potential conflict of interest relevant to this article was reported.

Fig. 1.

Chest radiograph during cardiopulmonary resuscitation shows increased haziness in the left lower lung field and suspicious right upper lung field consolidation. Both the previously inserted left-side catheter and the newly inserted right-side catheter are shown. The depth of the endotracheal tube and catheter seem to be adequate, and other possibilities of cardiac arrest such as tension pneumothorax were excluded.

Table 1.

Patient’s treatment course

Chemotherapy	1^st	2^nd	3^rd	4^th	5^th	6^th
Hb (g/dL)	4.7-11.6	7.9-12.8	7.4-10.8 DIC	6.3-12.2	7.1-12.2	8.3-11.7
WBC (K/μL)	0.36-49.86	0.2-9.04	1.83-5.2	0.92-7.71	0.57-7.56	2.37-4.3
PLT (K/μL)	14-522	9-504	96-284	50-373	5-650	75-325
PT (sec)	10.5-12.8	10.0-15.7	13.1	10.7-12.4	10.5-25.2	13.6-14.1
PTT (sec)	18.1-37.5	17.8-44.6	166.5	38.0-ncd	26.3-ncd	35.4-ncd
D dimer (μg/ml)	4.52	0.38-3.33	0.32	0.24-1.16	0.16-8.35	0.22-0.28
Fever (°C)		40		38.7	39	39.1
Performance state (ECOG)	1	3	2	2	3	2
Events	Chemoport insertion	Pneumonia R/O sepsis		Chemoport fixation	Sepsis, DIC, UTI, hepatitis	Hickmann catheter insertion

Hb: hemoglobin, WBC: white blood cell, PLT: platelet, PT: prothrombin time, PTT: partial thromboplastin time, ECOG: Eastern Cooperative Oncology Group, ncd: not clot detect, DIC: disseminated intravascular coagulation, UTI: urinary tract infection.

Table 2.

Difference between O₂ and CO₂ during CPR

	Initiation of CPR	After 5 min	After 20 min	After 30 min
EtCO₂ (mmHg)	19	Irregular	Irregular	Irregular
PaCO₂ (mmHg)	106	70	>115	>115
PAO₂ (mmHg)	580.5	625.5	569.3	569.3
PaO₂ (mmHg)	15	17	10	14
D (A-a) O₂ (mmHg)	565.5	608.5	559.3	555.3

D (A-a) O₂ was calculated as (FiO₂[P_atm-P_H2O]-PaCO₂/0.8)-PaO₂. P_atm: 760 mmHg, PH₂O: 47 mmHg. PaCO₂>115 was calculated as 115.

CPR: cardiopulmonary resuscitation, EtCO₂: end-tidal CO₂, PaCO₂: arterial CO₂ partial pressure, PaO₂: arterial O₂ partial pressure.

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