Skip Navigation
Skip to contents

ACC : Acute and Critical Care

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Search

Page Path
HOME > Search
36 "trauma"
Filter
Filter
Article category
Keywords
More +
Publication year
More +
Authors
More +
Funded articles
Review Article
Trauma
Hemostatic resuscitation in patients with trauma-induced coagulopathy: a narrative review
Junsik Kwon, Byung Hee Kang
Acute Crit Care. 2026;41(1):47-57.   Published online January 20, 2026
DOI: https://doi.org/10.4266/acc.003525
  • 2,187 View
  • 488 Download
AbstractAbstract PDF
Hemorrhage remains a leading cause of preventable death in trauma, emphasizing the importance of early bleeding control. In addition to mechanical hemostasis, effective management of trauma-induced coagulopathy (TIC) plays a critical role in improving outcomes. TIC is a multifactorial condition with diverse phenotypes, involving complex pathophysiology. These variations complicate early diagnosis and targeted treatment. In the prehospital setting, phenotype-based management is not feasible; thus, empirical strategies have been adopted. Administration of tranexamic acid and prehospital whole blood transfusion have shown clinical benefit in selected trauma populations. Upon hospital arrival, fixed-ratio massive transfusion protocols and whole blood resuscitation provide broad support for coagulopathic states and have proven effective in reducing early mortality. However, these approaches may not fully account for individual variation in coagulation profiles. Viscoelastic assays allow real-time evaluation of coagulation status and offer the potential for individualized, goal-directed therapy. While some studies suggest improved outcomes with viscoelastic-guided resuscitation, evidence of clear superiority over conventional methods remains limited. Further research is needed to determine the optimal resuscitation strategy and integrate both empirical and precision-based approaches in TIC management.
Original Articles
Trauma
Predictive value of elevated interleukin-33 levels for multi-organ dysfunction syndrome in trauma patients in South Korea: a prospective observational study
Sanghyun An, In Sik Shin, Myoung Jun Kim, Da Kyung Kim, Md Habibur Rahman, Cheol-Su Kim, Kwangmin Kim
Acute Crit Care. 2025;40(4):594-604.   Published online November 28, 2025
DOI: https://doi.org/10.4266/acc.002500
  • 604 View
  • 66 Download
AbstractAbstract PDFSupplementary Material
Background
Multi-organ distress syndrome (MODS) causes morbidity in patients with trauma. This study evaluates the effectiveness of interleukin-33 (IL-33), which reflects tissue damage and the inflammatory response, as a MODS indicator in patients with trauma.
Methods
Patients with trauma admitted to our trauma center between July 2022 and July 2023 were included. IL-33 levels were measured in blood samples for 4 days. Correlations with clinical and laboratory indicators, including initial IL-33 levels, were analyzed to identify independent predictors of MODS.
Results
Among the 87 patients enrolled, 20 developed MODS. Initial IL-33 levels were elevated in the MODS group, compared with the non-MODS group. In the non-MODS group, IL-33 levels increased on day 1 and then declined, whereas in the MODS group, IL-33 levels were highest at admission (day 0) and decreased continuously through day 3. In patients with detectable initial IL-33 levels, the measured levels correlated with higher Abbreviated Injury Scale 5 scores and the Injury Severity Score (ISS). A logistic regression analysis revealed the ISS and delta neutrophil index as factors contributing to MODS progression.
Conclusions
The findings suggest that initial IL-33 levels are elevated in the MODS group, compared with non-MODS group, and exhibit a rapidly declining trend, showing an initial association with MODS that was not maintained in a multivariate analysis. These findings suggest that IL-33 might have relevance in assessing trauma severity; however, further validation is required before it can be considered a biomarker for MODS.
Nutrition
Effect of standard- versus high-protein enteral feeding on rectus femoris muscle mass in mechanically ventilated traumatic brain injury patients: a prospective randomized study in Egypt and the United States
Hanan Elkalawy, Pavan Sekhar, Mona Fayad, Mohamed Barrima, Mohammad Abdullah
Acute Crit Care. 2026;41(1):160-173.   Published online November 24, 2025
DOI: https://doi.org/10.4266/acc.001025
  • 813 View
  • 30 Download
AbstractAbstract PDF
Background
Critically ill patients with muscle wasting experience prolonged intensive care unit (ICU) stays, delayed weaning, and higher mortality. Trauma-induced stress disrupts protein metabolism, leading to immunosuppression and muscle loss. This study evaluates whether high-protein intake through enteral nutrition preserves muscle mass and improves clinical outcomes compared to standard protein intake.
Methods
In our multicenter research, 102 critically ill, mechanically ventilated patients (age, 39±7; female, 52; body mass index, 23.8±2.7 kg/m2) were assigned randomly to receive either a high-protein (2.2 g/kg BW/day) or standard (1.5 g/kg BW/day) diet. Enteral nutrition was individualized based on energy expenditure. Ultrasound measured whether the rectus femoris muscle cross-sectional area (RFM-9 CSA) and pennation angle correlated with dietary intake. The data are presented as mean±standard deviation.
Results
Protein intake was 1.8±0.2 vs. 1.2±0.4 g/kg/day in high-protein and standard groups, respectively. In the intervention and standard groups, the baseline RFM-CSA and Pennation angle were 11.43±0.87 mm vs. 11.3±0.91 mm and 9.1±0.58 mm vs. 8.91±1.04 mm (P>0.05). Days 5, 10, and 20 showed significant variations in RFM-CSA and pennation angle (P<0.001). The intervention group experienced a shorter ICU length of stay (47±19.5 vs. 56.3±26.9 days, P=0.001) and a shorter period of mechanical ventilation (33±2.3 vs. 30±3.5 days, P=0.001).
Conclusions
Early high protein intake significantly preserves muscle mass, reducing the duration of stay in the ICU and the need for mechanical ventilation.
Epidemiology
Post-traumatic stress disorder, anxiety, and depression in North African intensive care unit survivors: a prospective observational study
Imen Ben Saida, Marwa Zghidi, Safa Fathallah, Mohamed Boussarsar
Acute Crit Care. 2025;40(3):402-412.   Published online August 29, 2025
DOI: https://doi.org/10.4266/acc.000150
  • 6,344 View
  • 126 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDFSupplementary Material
Background
Survivors of critical illness often face significant physical and psychological challenges, including post-traumatic stress disorder (PTSD), anxiety, and depression, which can severely impact their quality of life. This study aimed to evaluate the prevalence and associated factors of PTSD, anxiety, and depression among intensive care unit (ICU) survivors 3 months after discharge, and investigate the prevalence and determinants of post-intensive care syndrome–related neuropsychiatric disorders (PICS-ND).
Methods
This is a prospective observational analytical study carried out in a medical ICU. Three months after discharge from the ICU, survivors were contacted by telephone to complete the Impact Event Scale-Revised and Hospital Anxiety and Depression Scale questionnaires. Univariate and multivariate analyses were performed to identify variables that were independently and significantly associated with outcomes.
Results
A total of 114 survivors was enrolled. At 3 months, PTSD, anxiety, and depression were prevalent in 21.9%, 21.0%, and 9.6% of patients, respectively. Associated factors were younger age, female, physical restraint, and critical illness polyneuropathy and myopathy (CIPNM) for PTSD; unmarried, low Charlson index, and physical restraint for anxiety; and younger age and CIPNM for depression. PICS-ND, a composite measure of neuropsychiatric morbidity, was present in 28.9% of patients, with younger age, female, and physical restraint identified as associated factors.
Conclusions
PTSD, anxiety, depression, and PICS-ND were common among ICU survivors at 3 months. Various factors, including younger age, female, unmarried, lower Charlson index, physical restraint, and CIPNM, were associated with these psychological outcomes.

Citations

Citations to this article as recorded by  
  • Effect of high-dose baclofen on post-traumatic stress disorder symptoms five years after hospitalization among critically ill patients with unhealthy alcohol use
    Marwan Bouras, Karim Asehnoune, Yann Robert-Valli, Pierre-Joachim Mahe, Jean Reignier, Adel Maamar, Jean-Claude Lacherade, Maud Jonas, Boris Jung, Martine Ferrandiere, Samir Jaber, Laurent Flet, Mikael Moriconi, Sigismond Lasocki, Roland Smonig, Christoph
    Scientific Reports.2026;[Epub]     CrossRef
Neurosurgery
Cost-effectiveness of intracranial pressure monitoring in severe traumatic brain injury in Southern Thailand
Jidapa Jitchanvichai, Thara Tunthanathip
Acute Crit Care. 2025;40(1):69-78.   Published online February 21, 2025
DOI: https://doi.org/10.4266/acc.004080
  • 3,763 View
  • 135 Download
  • 3 Web of Science
  • 5 Crossref
AbstractAbstract PDFSupplementary Material
Background
Traumatic brain injury (TBI) is a leading cause of fatalities and disabilities in the public health domain, particularly in Thailand. Guidelines for TBI patients advise intracranial pressure monitoring (ICPm) for intensive care. However, information about the cost-effectiveness (CE) of ICPm in cases of severe TBI is lacking. This study assessed the CE of ICPm in severe TBI.
Methods
This was a retrospective cohort economic evaluation study from the perspective of the healthcare system. Direct costs were sourced from electronic medical records, and quality-adjusted life years (QALY) for each individual were computed using multiple linear regression with standardization. Incremental costs, incremental QALY, and the incremental CE ratio (ICER) were estimated, and the bootstrap method with 1,000 iterations was used in uncertainty analysis.
Results
The analysis included 821 individuals, with 4.1% undergoing intraparenchymal ICPm. The average cost of hospitalization was United States dollar ($)8,697.13 (±6,271.26) in both groups. The incremental cost and incremental QALY of the ICPm group compared with the non-ICPm group were $3,322.88 and –0.070, with the base-case ICER of $–47,504.08 per additional QALY. Results demonstrated that 0.007% of bootstrapped ICERs were below the willingness-to-pay (WTP) threshold of Thailand.
Conclusions
ICPm for severe TBI was not cost-effective compared with the WTP threshold of Thailand. Resource allocation for TBI prognosis requires further development of cost-effective treatment guidelines.

Citations

Citations to this article as recorded by  
  • Impact of Preoperative Hair Removal on Self-Esteem after Brain Tumor Surgery
    Thara Tunthanathip, Natthanee Pisitthaworakul
    Asian Journal of Neurosurgery.2026; 21(01): 147.     CrossRef
  • Deep learning-based model for detection of intracranial waveforms with poor brain compliance in southern Thailand
    Thara Tunthanathip, Avika Trakulpanitkit
    Acute and Critical Care.2025; 40(3): 473.     CrossRef
  • Feasibility comparison of deep learning image regressions to estimate intracranial pressure from cranial computed tomography in hydrocephalus
    Thara Tunthanathip, Rakkrit Duangsoithong, Sakchai Sae-Heng
    Journal of Neurosciences in Rural Practice.2025; 16: 606.     CrossRef
  • Risk factors and dose-response relationship of catheter-associated urinary tract infection in neurosurgical patients
    Thara Tunthanathip, Natthanee Pisitthaworakul
    International Journal of Nutrition, Pharmacology, Neurological Diseases.2025; 15(4): 451.     CrossRef
  • Prognosis of subarachnoid hemorrhage determined by intracranial pressure thresholds
    Thara Tunthanathip, Rakkrit Duangsoithong, Sakchai Sae-Heng
    Journal of Cerebrovascular and Endovascular Neurosurgery.2025; 27(4): 309.     CrossRef
Trauma
Predictive value of initial lactate levels for mortality and morbidity in critically ill pediatric trauma patients: a retrospective study from a Turkish pediatric intensive care unit
Abdulrahman Özel, Esra Nur İlbeği, Servet Yüce
Acute Crit Care. 2025;40(1):87-94.   Published online February 18, 2025
DOI: https://doi.org/10.4266/acc.003528
  • 6,482 View
  • 179 Download
  • 4 Web of Science
  • 5 Crossref
AbstractAbstract PDF
Background
This study investigated the relationship between initial lactate levels and both mortality and morbidity in critically ill pediatric trauma patients requiring intensive care.
Methods
This retrospective study at tertiary center’s pediatric intensive care unit from January 2020 to June 2024 aimed to characterize trauma patients and assess admission lactate levels' prognostic value.
Results
A total of 190 critically ill pediatric trauma patients were included in the study. The mortality rate was 7.9%, with most deaths occurring within the first 48 hours of admission. Initial lactate levels ≥6.9 mmol/L demonstrated moderate predictive power (area under the curve [AUC], 0.878) for mortality. Pediatric Risk of Mortality III (PRISM III) score showed good predictive ability (AUC, 0.922), while Pediatric Trauma Scores exhibited variable predictive performance (AUC, 0.863). Higher initial lactate levels were significantly associated with severe brain injury, the need for intubation, and an increased incidence of thoracic or abdominal injuries.
Conclusions
Initial lactate levels and PRISM III score are effective predictors of mortality in critically ill pediatric trauma patients. Lactate levels ≥5 mmol/L upon admission should prompt close monitoring and consideration of aggressive management strategies.

Citations

Citations to this article as recorded by  
  • Beyond survival: Early markers of poor outcome in pediatric trauma
    Kubra Boydag Guvenc, Ebru Guney Sahin, Idris Abdullah Yılmaz, Refik Ozturk, Ceyhan Sahin, Fatih Varol, Cansu Durak
    The American Journal of Emergency Medicine.2026; 101: 103.     CrossRef
  • PIM2, lactate, and trauma score to predict mortality in critically ill pediatric trauma patients
    Luciana G. Barcellos, Fernanda M. Rubin, Ana Paula P. da Silva, Júlia L. Vieira, Luciane G. da Cunha, Lucinara V. Enéas Machado, Geniara da S. Conrado, Cristian T. Tonial
    Jornal de Pediatria.2026; 102(2): 101509.     CrossRef
  • Prognostic value of lactate-to-albumin ratio and inflammatory indices in pediatric traumatic brain injury: A comparative study with PRISM III
    Özlem Bostan Gayret, Abdulrahman Özel, Servet Yüce, Harun Çatak, Selen Mandel Işikli, Meltem Erol
    Medicine.2026; 105(8): e47689.     CrossRef
  • Incidence, severity and outcomes of hypoxemia in paediatric emergencies seen at a tertiary hospital in Southern Nigeria
    Moses T. Abiodun, Gabriel Oziegbe, Imuwahen A. Mbarie, Wilson O. Osarogiagbon, Collins E. Etin-Osa, Rosena O. Oluwafemi, Godwin E. Okungbowa, Ovonomo Ewhe, Rahmon Olusola, Benjamin Nandom, Adesuwa Kpongo-Ogieva, Jane Aghama, Cyril Oputa
    International Journal of Contemporary Pediatrics.2025; 12(8): 1289.     CrossRef
  • Prognostic value of the lactate dehydrogenase-to-albumin ratio for predicting mortality in critically ill pediatric patients: a retrospective cohort study
    Ming Liu, Yunpeng Gou, Ping Yang
    Frontiers in Pediatrics.2025;[Epub]     CrossRef
Trauma
Factors associated with unplanned intensive care unit readmission among trauma patients in Republic of Korea
Yongwoong Lee, Byung Hee Kang
Acute Crit Care. 2024;39(4):583-592.   Published online November 22, 2024
DOI: https://doi.org/10.4266/acc.2024.00584
  • 3,090 View
  • 161 Download
  • 2 Crossref
AbstractAbstract PDF
Background
In trauma patients, unplanned intensive care unit (ICU) readmission (UIR) is associated with poor clinical outcomes. In this study, we aimed to analyze associated factors for UIR in trauma patients.
Methods
This retrospective study was conducted on trauma patients admitted to the ICU at a trauma center from January 2016 to December 2022. Clinical information at admission, the first ICU hospitalization, first discharge from the ICU, and reasons for readmission were collected. Patients who were successfully discharge from the ICU were compared to UIR patients. Logistic regression was performed to determine the factors with a significant impact on ICU readmission.
Results
Here, 5,529 patients were admitted to the ICU over 7 years, and 212 patients (3.8%) experienced UIR. Among patients who experienced UIR, 9 (4.2%) died. In the UIR patients, hospital stay (20 days [interquartile range, 13–35] vs. 45 days [28–67], P<0.001), total ICU stay (5 days [3– 11] vs. 17 days [9–35], P<0.001), and complications during the first ICU hospitalization were significantly higher. The most common reason for UIR was respiratory problem (53.8%). In multivariable analysis, cervical spine operation during the first ICU hospitalization (odds ratio, 6.56; 95% CI, 3.62–11.91; P<0.001), renal replacement therapy (RRT; 3.52, 2.06–5.99, P<0.001), and massive blood transfusion protocol (MTP; 1.74, 1.08–2.81, P=0.023) were most highly related with UIR.
Conclusions
Because UIR patients had poor outcomes, trauma patients who underwent cervical spine operation, RRT, or MTP require monitoring in the general ward, especially for respiratory problems.

Citations

Citations to this article as recorded by  
  • Unplanned intensive care unit admissions in trauma patients: A critical appraisal
    Amlan Swain, Deb Sanjay Nag, Jayanta Kumar Laik, Seelora Sahu, Mrunalkant Panchal, Shivani Srirala
    World Journal of Critical Care Medicine.2025;[Epub]     CrossRef
  • Circulation-first trauma resuscitation and mortality: A 9-year single-center retrospective study
    Donghwan Choi, Kyoungwon Jung
    Journal of Trauma and Acute Care Surgery.2025;[Epub]     CrossRef
Trauma
Bedside ultrasonographic evaluation of optic nerve sheath diameter for monitoring of intracranial pressure in traumatic brain injury patients: a cross sectional study in level II trauma care center in India
Sujit J. Kshirsagar, Anandkumar H. Pande, Sanyogita V. Naik, Alok Yadav, Ruchira M. Sakhala, Sangharsh M. Salve, Aysath Nuhaimah, Priyanka Desai
Acute Crit Care. 2024;39(1):155-161.   Published online February 23, 2024
DOI: https://doi.org/10.4266/acc.2023.01172
  • 14,742 View
  • 531 Download
  • 8 Web of Science
  • 8 Crossref
AbstractAbstract PDF
Background
Optic nerve sheath diameter (ONSD) is an emerging non-invasive, easily accessible, and possibly useful measurement for evaluating changes in intracranial pressure (ICP). The utilization of bedside ultrasonography (USG) to measure ONSD has garnered increased attention due to its portability, real-time capability, and lack of ionizing radiation. The primary aim of the study was to assess whether bedside USG-guided ONSD measurement can reliably predict increased ICP in traumatic brain injury (TBI) patients.
Methods
A total of 95 patients admitted to the trauma intensive care unit was included in this cross sectional study. Patient brain computed tomography (CT) scans and Glasgow Coma Scale (GCS) scores were assessed at the time of admission. Bedside USG-guided binocular ONSD was measured and the mean ONSD was noted. Microsoft Excel was used for statistical analysis.
Results
Patients with low GCS had higher mean ONSD values (6.4±1.0 mm). A highly significant association was found among the GCS, CT results, and ONSD measurements (P<0.001). Compared to CT scans, the bedside USG ONSD had 86.42% sensitivity and 64.29% specificity for detecting elevated ICP. The positive predictive value of ONSD to identify elevated ICP was 93.33%, and its negative predictive value was 45.00%. ONSD measurement accuracy was 83.16%.
Conclusions
Increased ICP can be accurately predicted by bedside USG measurement of ONSD and can be a valuable adjunctive tool in the management of TBI patients.

Citations

Citations to this article as recorded by  
  • Comparison of the Effects of Conventional and Piezoelectric Osteotomy on Intracranial Pressure Changes in Rhinoplasty Using Ultrasonographic Measurement of Optic Nerve Sheath Diameter
    Akif Gunes, Elif Karali, Yusuf Ozgur Bicer, Isa Yildiz, Sıddıka Halicioglu, Nurcan Akbas Gunes
    Aesthetic Plastic Surgery.2026;[Epub]     CrossRef
  • Exploring the impact of electroconvulsive therapy on intracranial pressure: A study of optic nerve sheath diameter measurements
    Iram Fatima, Aung Khine Phyoe, Abhimanyu Sharma, Shubh Mehta, Sara Tabassum, Manjeet Singh, Rama Siddiqui, Shivendra Shah, Kirpa Kaur, Hend Makky, Aadil Mahmood Khan
    The International Journal of Psychiatry in Medicine.2026; 61(1): 39.     CrossRef
  • Personalized treatment approaches in neurocritical care
    Jae Hyun Kim, Chang-Hyun Kim, Hanwool Jeon, Hyun-Chul Jung, Seungjoo Lee
    Acute and Critical Care.2026; 41(1): 33.     CrossRef
  • Assessment of optic nerve sheath enlargement and Frisen classification in idiopathic intracranial hypertension: Implications for estimating intracranial pressure and grading chronic papilledema
    Raghda Shawky El-Gendy, Ahmad Shehata Abd ElHamid, Ayman ElSayed Ali Galhom, Nihal Adel Hassan, Ehab Mahmoud Ghoneim
    Taiwan Journal of Ophthalmology.2025; 15(4): 618.     CrossRef
  • Bedside Ultrasonographic Measurement of Optic Nerve Sheath Diameter for Assessing Increased Intracranial Pressure: An Observational Study
    Saurav Shekhar, Raj B Singh, Preeti Sharma, Swapna Lata, Nitin Kumar, Ranjeet Rana De, Amit Kumar
    Cureus.2025;[Epub]     CrossRef
  • Noninvasive Intracranial Pressure Prediction Using a Multimodal Ultrasound-Based Hemispheric Modeling Strategy: A Prospective Dual-Center Study
    Jun Qiu, Tong-Juan Zou, Dong-Mei Wang, Hai-Rong Luo, Hai-Tao Yu, Ling Lei, Wan-Hong Yin
    Neurocritical Care.2025; 43(3): 911.     CrossRef
  • Correlation of Optic Nerve Sheath Diameter With Severity and Outcome in Head Injury: Ultrasonographic and CT Evaluation
    Syed Ali Mehsam, Sarosh Alam, Zunaira Rizwan , Haris Hanif, Fatima Tariq, Saharish Mansoor Khan
    Cureus.2025;[Epub]     CrossRef
  • Measurement of Optic Nerve Sheath Diameter by Bedside Ultrasound in Patients With Traumatic Brain Injury Presenting to Emergency Department: A Review
    Preethy Koshy, Charuta Gadkari
    Cureus.2024;[Epub]     CrossRef
Trauma
Role of platelet-to-lymphocyte ratio at the time of arrival to the emergency room as a predictor of short-term mortality in trauma patients with severe trauma team activation
Jae Kwang Kim, Kyung Hoon Sun
Acute Crit Care. 2024;39(1):146-154.   Published online February 15, 2024
DOI: https://doi.org/10.4266/acc.2023.01319
  • 10,242 View
  • 279 Download
  • 5 Web of Science
  • 7 Crossref
AbstractAbstract PDF
Background
Platelet-to-Lymphocyte ratio (PLR) has been studied as a prognostic factor for various diseases and traumas. This study examined the utility of PLR as a tool for predicting 30-day mortality in patients experiencing severe trauma.
Methods
This study included 139 patients who experienced trauma and fulfilled ≥1 criteria for activation of the hospital’s severe trauma team. Patients were divided into non-survivor and survivor groups. Mean PLR values were compared between the groups, the optimal PLR cut-off value was determined, and mortality and survival analyses were performed. Statistical analyses were performed using SPSS ver. 26.0. The threshold of statistical significance was P<0.05.
Results
There was a significant difference in mean (±standard deviation) PLR between the non-survivor (n=36) and survivor (n=103) groups (53.4±30.1 vs. 89.9±53.3, respectively; P<0.001). Receiver operating characteristic (ROC) curve analysis revealed an optimal PLR cut-off of 65.35 (sensitivity, 0.621; specificity, 0.694, respectively; area under the ROC curve, 0.742), and Kaplan-Meier survival analysis revealed a significant difference in mortality rate between the two groups.
Conclusions
PLR can be calculated quickly and easily from a routine complete blood count, which is often performed in the emergency department for individuals who experience trauma. The PLR is useful for predicting 30-day mortality in trauma patients with severe trauma team activation.

Citations

Citations to this article as recorded by  
  • Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Combined with Model for End-Stage Liver Disease 3.0 as a Prognostic Predictor for Patients with Liver Cirrhosis after Transjugular Intrahepatic Portosystemic Shunt Creation
    Takeshi Suzuki, Kenkichi Michimoto, Kentaro Yamada, Khashayar Farsad
    Journal of Vascular and Interventional Radiology.2026; 37(2): 107922.     CrossRef
  • Stabilized C-reactive protein–albumin–lymphocyte (CALLY) index predicts adjacent fractures after kyphoplasty
    Chunbiao Deng, Haiqiao Huang, Linlin Chen, Xin Chen, Qian Chen, Yougang Liao, Shuliang Li
    BMC Musculoskeletal Disorders.2026;[Epub]     CrossRef
  • Utility of platelet- to lymphocyte ratio as an inflammatory biomarker in major burns. our experience
    Dayamí Zaldívar Castillo MD, Néstor Nemer Pérez MD, Carlos Lora Buelvas MD, Adelmo de J González Méndez MD, Freddy J Cruz Reyes MD, Yaqueline Castellanos MD
    Journal of Anesthesia & Critical Care: Open Access.2025; 17(1): 1.     CrossRef
  • The predictors of prognostic nutritional index and its association with in-hospital mortality among critically ill geriatric patients
    Khalid Elsayed Elsorady, Ahmed Ahmed Mohamed Abotaha, Mohammed Abdelmoaty Ebrahim Shaheen, Hisham Ahmed Hani Mostafa Abdelaziz, Essam Yehia Ali Aggour, Mohamed Elwan Mohamed Mahmoud
    Electronic Journal of General Medicine.2025; 22(4): em656.     CrossRef
  • Key laboratory changes in severe trauma, a different pattern for each clinical phenotype
    Adrián Marcos-Morales, Jesús Abelardo Barea Mendoza, Marcos Valiente Fernández, Carlos García Fuentes, Fernando Calvo Boyero, Cecilia Cueto-Felgueroso, Judith Gutiérrez Gutiérrez, Francisco de Paula Delgado Moya, Carolina Mudarra Reche, Susana Bermejo Azn
    Medicina Intensiva (English Edition).2025; : 502227.     CrossRef
  • Prognostic Value of Inflammatory and Metabolic Biomarkers in ICU-Admitted Trauma Patients: A Retrospective Cohort Study
    Hasan Celik, Basak Pehlivan, Veli Fahri Pehlivan, Erdogan Duran
    Medicina.2025; 61(9): 1530.     CrossRef
  • Utility of systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio as a predictive biomarker in pediatric traumatic brain injury
    Muhammad Arifin Parenrengi, Wihasto Suryaningtyas, Ahmad Data Dariansyah, Budi Utomo, Glenn Otto Taryana, Catur Kusumo, Surya Pratama Brilliantika
    Surgical Neurology International.2024; 15: 456.     CrossRef
Review Article
Trauma
Mobilization phases in traumatic brain injury
Tommy Alfandy Nazwar, Ivan Triangto, Gutama Arya Pringga, Farhad Bal’afif, Donny Wisnu Wardana
Acute Crit Care. 2023;38(3):261-270.   Published online August 1, 2023
DOI: https://doi.org/10.4266/acc.2023.00640
  • 20,833 View
  • 540 Download
  • 7 Web of Science
  • 8 Crossref
AbstractAbstract PDF
Mobilization in traumatic brain injury (TBI) have shown the improvement of length of stay, infection, long term weakness, and disability. Primary damage as a result of trauma’s direct effect (skull fracture, hematoma, contusion, laceration, and nerve damage) and secondary damage caused by trauma’s indirect effect (microvasculature damage and pro-inflammatory cytokine) result in reduced tissue perfusion & edema. These can be facilitated through mobilization, but several precautions must be recognized as mobilization itself may further deteriorate patient’s condition. Very few studies have discussed in detail regarding mobilizing patients in TBI cases. Therefore, the scope of this review covers the detail of physiological effects, guideline, precautions, and technique of mobilization in patients with TBI.

Citations

Citations to this article as recorded by  
  • Benchmarking mobilization practice and functional outcomes in traumatic brain injury patients admitted to the intensive care unit: a three-year service evaluation
    Fiona Howroyd, James Hodson, Anne Preece, Tammy Lea, Samantha Rooney, Hon Sing Geoffrey Wu, Simran Rahania, Fang Gao Smith, Tonny Veenith, Niharika A. Duggal, Zubair Ahmed, Jonathan Weblin
    Frontiers in Neurology.2026;[Epub]     CrossRef
  • The Impact of a Prior Traumatic Brain Injury and Injury Characteristics on Frailty in the Canadian Longitudinal Study on Aging
    Molly K. Courish, Myles W. O’Brien, Madeline E. Shivgulam, Emily E. MacDonald, Said Mekari, Olga Theou
    Archives of Physical Medicine and Rehabilitation.2026;[Epub]     CrossRef
  • Reversing Persistent PTEN Activation after Traumatic Brain Injury Fuels Long‐Term Axonal Regeneration via Akt/mTORC1 Signaling Cascade
    Ziyu Shi, Leilei Mao, Shuning Chen, Zhuoying Du, Jiakun Xiang, Minghong Shi, Yana Wang, Yuqing Wang, Xingdong Chen, Zhi‐Xiang Xu, Yanqin Gao
    Advanced Science.2025;[Epub]     CrossRef
  • Falls in a single brain rehabilitation center: a 3-year retrospective chart review
    Yoo Jin Choo, Jun Sung Moon, Gun Woo Lee, Wook-Tae Park, Min Cheol Chang
    Frontiers in Neurology.2025;[Epub]     CrossRef
  • Effects of using conventional assistive devices on spatiotemporal gait parameters of adults with neurological disorders: A systematic review protocol
    Jordana de Paula Magalhães, Sheridan Ayessa Ferreira de Brito, Merrill Landers, Aline Alvim Scianni, Poliana do Amaral Yamaguchi Benfica, Carolina Luisa de Almeida Soares, Christina Danielli Coelho de Morais Faria, Anne E. Martin
    PLOS ONE.2025; 20(4): e0321019.     CrossRef
  • Impact of Early Mobilisation on the Clinical Outcomes of Patients With Traumatic Brain Injury
    Fei Xia, Caiyun Li, Yiwen Liu
    Nursing in Critical Care.2025;[Epub]     CrossRef
  • Acute orthostatic responses during early mobilisation of patients with acquired brain injury - Innowalk pro versus standing frame
    Matthijs F Wouda, Espen I Bengtson, Ellen Høyer, Alhed P Wesche, Vivien Jørgensen
    Journal of Rehabilitation and Assistive Technologies Engineering.2024;[Epub]     CrossRef
  • Aktuelle Aspekte der intensivmedizinischen Versorgung bei Schädel-Hirn-Trauma – Teil 2
    André Hagedorn, Helge Haberl, Michael Adamzik, Alexander Wolf, Matthias Unterberg
    AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie.2024; 59(07/08): 466.     CrossRef
Original Articles
Trauma
Comparison of admission GCS score to admission GCS-P and FOUR scores for prediction of outcomes among patients with traumatic brain injury in the intensive care unit in India
Nishant Agrawal, Shivakumar S Iyer, Vishwanath Patil, Sampada Kulkarni, Jignesh N Shah, Prashant Jedge
Acute Crit Care. 2023;38(2):226-233.   Published online May 25, 2023
DOI: https://doi.org/10.4266/acc.2023.00570
  • 13,955 View
  • 320 Download
  • 8 Web of Science
  • 10 Crossref
AbstractAbstract PDF
Background
This study aimed to determine the predictive power of the Full Outline of Unresponsiveness (FOUR) score and the Glasgow Coma Scale Pupil (GCS-P) score in determining outcomes for traumatic brain injury (TBI) patients. The Glasgow Outcome Scale (GOS) was used to evaluate patients at 1 month and 6 months after the injury.
Methods
We conducted a 15-month prospective observational study. It included 50 TBI patients admitted to the ICU who met our inclusion criteria. We used Pearson’s correlation coefficient to relate coma scales and outcome measures. The predictive value of these scales was determined using the receiver operating characteristic (ROC) curve, calculating the area under the curve with a 99% confidence interval. All hypotheses were two-tailed, and significance was defined as P<0.01.
Results
In the present study, the GCS-P and FOUR scores among all patients on admission as well as in the subset of patients who were mechanically ventilated were statistically significant and strongly correlated with patient outcomes. The correlation coefficient of the GCS score compared to GCS-P and FOUR scores was higher and statistically significant. The areas under the ROC curve for the GCS, GCS-P, and FOUR scores and the number of computed tomography abnormalities were 0.912, 0.905, 0.937, and 0.324, respectively.
Conclusions
The GCS, GCS-P, and FOUR scores are all excellent predictors with a strong positive linear correlation with final outcome prediction. In particular, the GCS score has the best correlation with final outcome.

Citations

Citations to this article as recorded by  
  • Association Between Glasgow Coma Scale Trajectory and In‐Hospital Mortality in Traumatic Brain Injury in the ICU: A Retrospective Cohort Study
    Yangchun Zhang, Feng Chen, Na Ma, Cairong Liu, Xufeng Chen, Xueli Ji
    Nursing in Critical Care.2025;[Epub]     CrossRef
  • Epidemiology and Outcome of Traumatic Brain Injuries: A Retrospective Study in a Tertiary Care Center
    Rudra N Shah, Yam B Roka, Ashish J Thapa, Alok Jha, Chandan N Sah
    Cureus.2025;[Epub]     CrossRef
  • Comparison of the Accuracy of the GCS and FOUR Scores in Predicting Mortality of Patients with Traumatic Brain Injury (TBI) Admitted to the Emergency Department: A Prospective Study in Khorramabad, Iran
    Amirhossein Pashaei, Soodabeh Zare, Peiman Bakhshi, Sara Fakhri
    Shiraz E-Medical Journal.2025;[Epub]     CrossRef
  • Dynamic assessment of the prognostic value of scoring systems FOUR, GCS and CRS-R in patients with chronic critical illness after acute brain injury
    L. B. Berikashvili, M. Ya. Yadgarov, D. V. Zhidilyaev, K. K. Kadantseva, E. M. Korolenok, A. A. Yakovlev, A. N. Kuzovlev, V. V. Likhvantsev
    Messenger of ANESTHESIOLOGY AND RESUSCITATION.2025; 22(6): 39.     CrossRef
  • ASSOCIATION OF AGE AND FOUR SCORE WITH ICU LENGTH OF STAY IN POST-CRANIOTOMY PATIENTS AT SAKINAH HOSPITAL MOJOKERTO
    Rudi Hariyono, Ika Ainur Rofi’ah
    International Journal of Nursing and Midwifery Science (IJNMS).2025; 9(3): 506.     CrossRef
  • Development of a Novel Neurological Score Combining GCS and FOUR Scales for Assessment of Neurosurgical Patients with Traumatic Brain Injury: GCS-FOUR Scale
    Ali Ansari, Sina Zoghi, Amirabbas Khoshbooei, Mohammad Amin Mosayebi, Maryam Feili, Omid Yousefi, Amin Niakan, Seyed Amin Kouhpayeh, Reza Taheri, Hosseinali Khalili
    World Neurosurgery.2024; 182: e866.     CrossRef
  • Comparison of Glasgow Coma Scale Full Outline of UnResponsiveness and Glasgow Coma Scale: Pupils Score for Predicting Outcome in Patients with Traumatic Brain Injury
    Indu Kapoor, Hemanshu Prabhakar, Arvind Chaturvedi, Charu Mahajan, Abraham L Chawnchhim, Tej P Sinha
    Indian Journal of Critical Care Medicine.2024; 28(3): 256.     CrossRef
  • Machine learning for the prediction of in-hospital mortality in patients with spontaneous intracerebral hemorrhage in intensive care unit
    Baojie Mao, Lichao Ling, Yuhang Pan, Rui Zhang, Wanning Zheng, Yanfei Shen, Wei Lu, Yuning Lu, Shanhu Xu, Jiong Wu, Ming Wang, Shu Wan
    Scientific Reports.2024;[Epub]     CrossRef
  • The assessment of consciousness status in primary brainstem hemorrhage (PBH) patients can be achieved by monitoring changes in basic vital signs
    Shiyi Zuo, Yuting Feng, Juan Sun, Guofang Liu, Hanxu Cai, Xiaolong Zhang, Zhian Hu, Yong Liu, Zhongxiang Yao
    Geriatric Nursing.2024; 59: 498.     CrossRef
  • Traumatic brain injury in companion animals: Pathophysiology and treatment
    Molly Wart, Thomas H. Edwards, Julie A. Rizzo, Geoffrey W. Peitz, Armi Pigott, Jonathan M. Levine, Nicholas D. Jeffery
    Topics in Companion Animal Medicine.2024; 63: 100927.     CrossRef
Nephrology
Epidemiology and outcome of an acute kidney injuries in the polytrauma victims admitted at the apex trauma center in Dubai
Bhushan Sudhakar Wankhade, Zeyad Faoor Alrais, Ghaya Zeyad Alrais, Ammar Mohamed Abdel Hadi, Gopala Arun Kumar Naidu, Mohammed Shahid Abbas, Ahmed Tarek Youssef Aboul Kheir, Hasan Hadad, Sundareswaran Sharma, Mohammad Sait
Acute Crit Care. 2023;38(2):217-225.   Published online May 25, 2023
DOI: https://doi.org/10.4266/acc.2023.00388
  • 6,150 View
  • 129 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Background
Polytrauma from road accidents is a common cause of hospital admissions and deaths, frequently leading to acute kidney injury (AKI) and impacting patient outcomes.
Methods
This retrospective, single-center study included polytrauma victims with an Injury Severity Score (ISS) >25 at a tertiary healthcare center in Dubai.
Results
The incidence of AKI in polytrauma victims is 30.5%, associated with higher Carlson comorbidity index (P=0.021) and ISS (P=0.001). Logistic regression shows a significant relationship between ISS and AKI (odds ratio [OR], 1.191; 95% confidence interval [CI], 1.150–1.233; P<0.05). The main causes of trauma-induced AKI are hemorrhagic shock (P=0.001), need for massive transfusion (P<0.001), rhabdomyolysis (P=0.001), and abdominal compartment syndrome (ACS; P<0.001). On multivariate logistic regression AKI can be predicated by higher ISS (OR, 1.08; 95% CI, 1.00–1.17; P=0.05) and low mixed venous oxygen saturation (OR, 1.13; 95% CI, 1.05–1.22; P<0.001). The development of AKI after polytrauma increases length of stay (LOS)-hospital (P=0.006), LOS-intensive care unit (ICU; P=0.003), need for mechanical ventilation (MV) (P<0.001), ventilator days (P=0.001), and mortality (P<0.001).
Conclusions
After polytrauma, the occurrence of AKI leads to prolonged hospital and ICU stays, increased need for mechanical ventilation, more ventilator days, and a higher mortality rate. AKI could significantly impact their prognosis.

Citations

Citations to this article as recorded by  
  • Normotensive trauma patients with renal injuries: Hidden candidates for massive transfusion
    Xin‐Hong Lin, Pi‐Chieh Lin, Ching‐Hua Tsai, Wei‐Ti Su, Shiun‐Yuan Hsu, Ching‐Hua Hsieh
    Hong Kong Journal of Emergency Medicine.2025;[Epub]     CrossRef
  • Acute kidney injury in critically ill patients with traumatic brain injury: A single-center retrospective cohort study
    Bhushan Sudhakar Wankhade, Mohamed Hamed Ibrahim Ali El Kholi, Zeyad Faoor Alrais, Adel Elsaid Salem Elkhouly, Gopala Arun Kumar Naidu, Alim Akbar Patel, Mohamed Sameer, Mohammed Shahid Abbas, Nowar Nouralla Fadol Elbasier, Aala Fadlalla El Hadi
    World Journal of Critical Care Medicine.2025;[Epub]     CrossRef
Trauma
Selection of appropriate reference creatinine estimate for acute kidney injury diagnosis in patients with severe trauma
Kangho Lee, Dongyeon Ryu, Hohyun Kim, Sungjin Park, Sangbong Lee, Chanik Park, Gilhwan Kim, Sunhyun Kim, Nahyeon Lee
Acute Crit Care. 2023;38(1):95-103.   Published online February 27, 2023
DOI: https://doi.org/10.4266/acc.2022.01046
  • 6,725 View
  • 127 Download
AbstractAbstract PDF
Background
In patients with severe trauma, the diagnosis of acute kidney injury (AKI) is important because it is a predictive factor for poor prognosis and can affect patient care. The diagnosis and staging of AKI are based on change in serum creatinine (SCr) levels from baseline. However, baseline creatinine levels in patients with traumatic injuries are often unknown, making the diagnosis of AKI in trauma patients difficult. This study aimed to enhance the accuracy of AKI diagnosis in trauma patients by presenting an appropriate reference creatinine estimate (RCE).
Methods
We reviewed adult patients with severe trauma requiring intensive care unit admission between 2015 and 2019 (n=3,228) at a single regional trauma center in South Korea. AKI was diagnosed based on the current guideline published by the Kidney Disease: Improving Global Outcomes organization. AKI was determined using the following RCEs: estimated SCr75-modification of diet in renal disease (MDRD), trauma MDRD (TMDRD), admission creatinine level, and first-day creatinine nadir. We assessed inclusivity, prognostic ability, and incrementality using the different RCEs.
Results
The incidence of AKI varied from 15% to 46% according to the RCE used. The receiver operating characteristic curve of TMDRD used to predict mortality and the need for renal replacement therapy (RRT) had the highest value and was statistically significant (0.797, P<0.001; 0.890, P=0.002, respectively). In addition, the use of TMDRD resulted in a mortality prognostic ability and the need for RRT was incremental with AKI stage.
Conclusions
In this study, TMDRD was feasible as a RCE, resulting in optimal post-traumatic AKI diagnosis and prognosis.
Case Report
Neurosurgery
Use of droxidopa for blood pressure augmentation after acute spinal cord injury: case reports
Christopher S. Hong, Muhammad K. Effendi, Abdalla A. Ammar, Kent A. Owusu, Mahmoud A. Ammar, Andrew B. Koo, Layton A. Lamsam, Aladine A. Elsamadicy, Gregory A. Kuzmik, Maxwell Laurans, Michael L. DiLuna, Mark L. Landreneau
Acute Crit Care. 2025;40(1):138-143.   Published online December 7, 2022
DOI: https://doi.org/10.4266/acc.2021.01662
  • 9,460 View
  • 238 Download
  • 3 Web of Science
  • 4 Crossref
AbstractAbstract PDF
Hypotension secondary to autonomic dysfunction is a common complication of acute spinal cord injury (SCI) that may worsen neurologic outcomes. Midodrine, an enteral α-1 agonist, is often used to facilitate weaning intravenous (IV) vasopressors, but its use can be limited by reflex bradycardia. Alternative enteral agents to facilitate this wean in the acute post-SCI setting have not been described. We aim to describe novel application of droxidopa, an enteral precursor of norepinephrine that is approved to treat neurogenic orthostatic hypotension, in the acute post-SCI setting. Droxidopa may be an alternative enteral therapy for those intolerant of midodrine due to reflex bradycardia. We describe two patients suffering traumatic cervical SCI who were successfully weaned off IV vasopressors with droxidopa after failing with midodrine. The first patient was a 64-year-old male who underwent C3–6 laminectomies and fusion after a ten-foot fall resulting in quadriparesis. Post-operatively, the addition of midodrine in an attempt to wean off IV vasopressors resulted in significant reflexive bradycardia. Treatment with droxidopa facilitated rapidly weaning IV vasopressors and transfer to a lower level of care within 72 hours of treatment initiation. The second patient was a 73-year-old male who underwent C3–5 laminectomies and fusion for a traumatic hyperflexion injury causing paraplegia. The addition of midodrine resulted in severe bradycardia, prompting consideration of pacemaker placement. However, with the addition of droxidopa, this was avoided, and the patient was weaned off IV vasopressors on dual oral therapy with midodrine and droxidopa. Droxidopa may be a viable enteral therapy to treat hypotension in patients after acute SCI who are otherwise not tolerating midodrine in order to wean off IV vasopressors. This strategy may avoid pacemaker placement and facilitate shorter stays in the intensive care unit, particularly for patients who are stable but require continued intensive care unit admission for IV vasopressors, which can be cost ineffective and human resource depleting.

Citations

Citations to this article as recorded by  
  • A Guide to the Use of Vasopressors and Inotropes for Patients in Shock
    Anaas Moncef Mergoum, Abigail Rebecca Rhone, Nicholas James Larson, David J Dries, Benoit Blondeau, Frederick Bolles Rogers
    Journal of Intensive Care Medicine.2025; 40(7): 726.     CrossRef
  • Droxidopa for Intravenous Vasopressor Weaning in the Intensive Care Unit: A Descriptive Study
    Calvin Diep, Daniella Veloria, Amy Kloosterboer
    Therapeutics.2025; 2(4): 20.     CrossRef
  • Droxidopa in Critical Care: A Systematic Review of an Emerging Off‐Label Practice
    Carlos Valladares, Franklyn Vega Batista, Marc Faltas, Mareya Menteyas, Katherine Chiapaikeo-Poco, Edward A. Bittner
    Critical Care Research and Practice.2025;[Epub]     CrossRef
  • Oral blood pressure augmenting agents for intravenous vasopressor weaning
    John C Robinson, Mariam ElSaban, Nathan J Smischney, Patrick M Wieruszewski
    World Journal of Clinical Cases.2024; 12(36): 6892.     CrossRef
Review Article
Neurosurgery
Target temperature management in traumatic brain injury with a focus on adverse events, recognition, and prevention
Kwang Wook Jo
Acute Crit Care. 2022;37(4):483-490.   Published online November 10, 2022
DOI: https://doi.org/10.4266/acc.2022.01291
  • 15,780 View
  • 474 Download
  • 8 Web of Science
  • 9 Crossref
AbstractAbstract PDF
Traumatic brain injury (TBI) is a critical cause of disability and death worldwide. Many studies have been conducted aimed at achieving favorable neurologic outcomes by reducing secondary brain injury in TBI patients. However, ground-breaking outcomes are still insufficient so far. Because mild-to-moderate hypothermia (32°C–35°C) has been confirmed to help neurological recovery for recovered patients after circulatory arrest, it has been recognized as a major neuroprotective treatment plan for TBI patients. Thereafter, many clinical studies about the effect of therapeutic hypothermia (TH) on severe TBI have been conducted. However, efficacy and safety have not been demonstrated in many large-scale randomized controlled studies. Rather, some studies have demonstrated an increase in mortality rate due to complications such as pneumonia, so it is not highly recommended for severe TBI patients. Recently, some studies have shown results suggesting TH may help reperfusion/ischemic injury prevention after surgery in the case of mass lesions, such as acute subdural hematoma, and it has also been shown to be effective in intracranial pressure control. In conclusion, TH is still at the center of neuroprotective therapeutic studies regarding TBI. If proper measures can be taken to mitigate the many adverse events that may occur during the course of treatment, more positive efficacy can be confirmed. In this review, we look into adverse events that may occur during the process of the induction, maintenance, and rewarming of targeted temperature management and consider ways to prevent and address them.

Citations

Citations to this article as recorded by  
  • Target temperature management in acute ischemic stroke
    Lan Gao, Ting Yang, Hong Chong, Longfei Wu, Jinming Han
    Frontiers in Molecular Biosciences.2026;[Epub]     CrossRef
  • Blood pressure variability and functional outcome after decompressive hemicraniectomy in malignant middle cerebral artery infarction
    Jae Wook Jung, Ilmo Kang, Jin Park, Sang‐Beom Jeon
    European Journal of Neurology.2025;[Epub]     CrossRef
  • State-of-the-art for automated machine learning predicts outcomes in poor-grade aneurysmal subarachnoid hemorrhage using routinely measured laboratory & radiological parameters: coagulation parameters and liver function as key prognosticators
    Ali Haider Bangash, Jayro Toledo, Muhammed Amir Essibayi, Neil Haranhalli, Rafael De la Garza Ramos, David J. Altschul, Stavropoula Tjoumakaris, Reza Yassari, Robert M. Starke, Redi Rahmani
    Neurosurgical Review.2025;[Epub]     CrossRef
  • Advancements in the application of multimodal monitoring and machine learning for the development of personalized therapeutic strategies in traumatic brain injury
    Zhijing Wei, Lingda Meng, Wei Chong
    Frontiers in Human Neuroscience.2025;[Epub]     CrossRef
  • Trends and hotspots in research of traumatic brain injury from 2000 to 2022: A bibliometric study
    Yan-rui Long, Kai Zhao, Fu-chi Zhang, Yu Li, Jun-wen Wang, Hong-quan Niu, Jin Lei
    Neurochemistry International.2024; 172: 105646.     CrossRef
  • Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations
    Andrea Lavinio, Jonathan P. Coles, Chiara Robba, Marcel Aries, Pierre Bouzat, Dara Chean, Shirin Frisvold, Laura Galarza, Raimund Helbok, Jeroen Hermanides, Mathieu van der Jagt, David K. Menon, Geert Meyfroidt, Jean-Francois Payen, Daniele Poole, Frank R
    Critical Care.2024;[Epub]     CrossRef
  • A review on targeted temperature management for cardiac arrest and traumatic brain injury
    Hiroshi Ito, Sanae Hosomi, Takeshi Nishida, Youhei Nakamura, Jiro Iba, Hiroshi Ogura, Jun Oda
    Frontiers in Neuroscience.2024;[Epub]     CrossRef
  • Intracranial pressure trends and clinical outcomes after decompressive hemicraniectomy in malignant middle cerebral artery infarction
    Jae Wook Jung, Ilmo Kang, Jin Park, Seungjoo Lee, Sang-Beom Jeon
    Annals of Intensive Care.2024;[Epub]     CrossRef
  • Severe traumatic brain injury in adults: a review of critical care management
    Siobhan McLernon
    British Journal of Neuroscience Nursing.2023; 19(6): 206.     CrossRef
Original Articles
Trauma
C-reactive protein-albumin ratio and procalcitonin in predicting intensive care unit mortality in traumatic brain injury
Canan Gürsoy, Güven Gürsoy, Semra Gümüş Demirbilek
Acute Crit Care. 2022;37(3):462-467.   Published online August 5, 2022
DOI: https://doi.org/10.4266/acc.2022.00052
  • 6,814 View
  • 204 Download
  • 10 Web of Science
  • 10 Crossref
AbstractAbstract PDF
Background
Prediction of intensive care unit (ICU) mortality in traumatic brain injury (TBI), which is a common cause of death in children and young adults, is important for injury management. Neuroinflammation is responsible for both primary and secondary brain injury, and C-reactive protein-albumin ratio (CAR) has allowed use of biomarkers such as procalcitonin (PCT) in predicting mortality. Here, we compared the performance of CAR and PCT in predicting ICU mortality in TBI.
Methods
Adults with TBI were enrolled in our study. The medical records of 82 isolated TBI patients were reviewed retrospectively.
Results
The mean patient age was 49.0 ± 22.69 years; 59 of all patients (72%) were discharged, and 23 (28%) died. There was a statistically significant difference between PCT and CAR values according to mortality (P<0.05). The area under the curve (AUC) was 0.646 with 0.071 standard error for PCT and 0.642 with 0.066 standard error for CAR. The PCT showed a similar AUC of the receiver operating characteristic to CAR.
Conclusions
This study shows that CAR and PCT are usable biomarkers to predict ICU mortality in TBI. When the determined cut-off values are used to predict the course of the disease, the CAR and PCT biomarkers will provide more effective information for treatment planning and for preparation of the family for the treatment process and to manage their outcome expectations.

Citations

Citations to this article as recorded by  
  • Performance and accuracy of blood glucose and neutrophil-lymphocyte ratio as predictors of mortality in children and adolescents with traumatic brain injury
    José Roberto Tude Melo, Caio Vinicius de Almeida Chaves, Cindy Kawano, Isabela Zampirolli Leal, Maria Antonia Coladeti Fernandes, Stephannie Monaco Bodra, Jean Gonçalves de Oliveira, José Carlos Esteves Veiga
    Child's Nervous System.2026;[Epub]     CrossRef
  • Prognostic value of CAR, FIB-4, and procalcitonin in subdural hematoma: associations with mortality and 90-day functional outcomes running title: CAR, FIB-4, and procalcitonin in SDH outcomes
    Tamer Tamdoğan, İlke Tamdoğan
    Journal of Health Sciences and Medicine.2026; 9(1): 19.     CrossRef
  • One-Year Mortality After Percutaneous Endoscopic Gastrostomy: The Prognostic Role of Nutritional Biomarkers and Care Settings
    Nermin Mutlu Bilgiç, Güldan Kahveci, Ekmel Burak Özşenel, Sema Basat
    Nutrients.2025; 17(5): 904.     CrossRef
  • Elevation of C-reactive protein and homocysteine levels as reliable biomarkers for assessing injury severity and prognosis in traumatic brain injury
    Zi-Yan Wang, Wei Du, Xian-Zhi Liu, Yuan Li, Jun Liu
    Scientific Reports.2025;[Epub]     CrossRef
  • Prognostic value of procalcitonin and IL-6 with a composite model in moderate-severe traumatic brain injury
    Xin-meng Li, Zi-wei Liu, Wei-yu Liu, Gao-jian Su, Xian-jian Huang
    Journal of Clinical Neuroscience.2025; 140: 111516.     CrossRef
  • Development and validation of a prediction model for pulmonary infection in elderly patients with traumatic brain injury
    Shuai Tian, Ali Shang, Wenqian Zhou, Zhen Xu, Yunpeng Kou, Zhenyu Guo, Fan Chen, Peigang Ji, Yulong Zhai, Wenjian Zhao, Yang Jiao, Zhipeng Song, Shunnan Ge, Yuan Wang, Liang Wang, Shaochun Guo
    Neurochirurgie.2025; 71(6): 101733.     CrossRef
  • Albuminemia as a Potential Predictor of Clinical Outcomes in Patients with Severe Traumatic Brain Injury (TBI)
    Luka Stepanovic, Usha Govindarajulu, George Agriantonis, Navin D. Bhatia, Jasmine Dave, Shalini Arora, Zahra Shafaee, Kate Twelker, Jennifer Whittington, Bharti Sharma
    Journal of Clinical Medicine.2025; 14(21): 7499.     CrossRef
  • Research Advances in CAR, NLR, and S100β for Assessing Neurological Functional Prognosis in Traumatic Brain Injury Patients
    明隆 陈
    Advances in Clinical Medicine.2025; 15(10): 2518.     CrossRef
  • Symptoms and Functional Outcomes Among Traumatic Brain Injury Patients 3- to 12-Months Post-Injury
    Kathryn S. Gerber, Gemayaret Alvarez, Arsham Alamian, Victoria Behar-Zusman, Charles A. Downs
    Journal of Trauma Nursing.2024; 31(2): 72.     CrossRef
  • Association of C-reactive protein/albumin ratio with mortality in patients with Traumatic Brain Injury: A systematic review and meta-analysis
    Yuyang Liu, Yaheng Tan, Jun Wan, Qiwen Chen, Yuxin Zheng, Wenhao Xu, Peng Wang, Weelic Chong, Xueying Yu, Yu Zhang
    Heliyon.2024; 10(13): e33460.     CrossRef
Neurosurgery
Development and internal validation of a nomogram for predicting outcomes in children with traumatic subdural hematoma
Anukoon Kaewborisutsakul, Thara Tunthanathip
Acute Crit Care. 2022;37(3):429-437.   Published online June 23, 2022
DOI: https://doi.org/10.4266/acc.2021.01795
  • 5,589 View
  • 228 Download
  • 12 Web of Science
  • 14 Crossref
AbstractAbstract PDF
Background
A subdural hematoma (SDH) following a traumatic brain injury (TBI) in children can lead to unexpected death or disability. The nomogram is a clinical prediction tool used by physicians to provide prognosis advice to parents for making decisions regarding treatment. In the present study, a nomogram for predicting outcomes was developed and validated. In addition, the predictors associated with outcomes in children with traumatic SDH were determined.
Methods
In this retrospective study, 103 children with SDH after TBI were evaluated. According to the King’s Outcome Scale for Childhood Head Injury classification, the functional outcomes were assessed at hospital discharge and categorized into favorable and unfavorable. The predictors associated with the unfavorable outcomes were analyzed using binary logistic regression. Subsequently, a two-dimensional nomogram was developed for presentation of the predictive model.
Results
The predictive model with the lowest level of Akaike information criterion consisted of hypotension (odds ratio [OR], 9.4; 95% confidence interval [CI], 2.0–42.9), Glasgow coma scale scores of 3–8 (OR, 8.2; 95% CI, 1.7–38.9), fixed pupil in one eye (OR, 4.8; 95% CI, 2.6–8.8), and fixed pupils in both eyes (OR, 3.5; 95% CI, 1.6–7.1). A midline shift ≥5 mm (OR, 1.1; 95% CI, 0.62–10.73) and co-existing intraventricular hemorrhage (OR, 6.5; 95% CI, 0.003–26.1) were also included.
Conclusions
SDH in pediatric TBI can lead to mortality and disability. The predictability level of the nomogram in the present study was excellent, and external validation should be conducted to confirm the performance of the clinical prediction tool.

Citations

Citations to this article as recorded by  
  • The Prognostic Value of Immunonutritional Indexes in Pineal Region Tumor
    Suchada Supbumrung, Anukoon Kaewborisutsakul, Thara Tunthanathip
    Journal of Health and Allied Sciences NU.2025; 15(01): 109.     CrossRef
  • Dynamic nomogram for predicting long-term survival in patients with brain abscess
    Thara Tunthanathip, Rakkrit Duangsoithong, Waranyu Kittirojkasem, Akira Pongweat, Rattiyaphon Khongthep, Benchamat Sutchai, Assama Tohyunuh
    Chinese Neurosurgical Journal.2025;[Epub]     CrossRef
  • Impact of Preoperative Hair Removal on Self-Esteem after Brain Tumor Surgery
    Thara Tunthanathip, Natthanee Pisitthaworakul
    Asian Journal of Neurosurgery.2025;[Epub]     CrossRef
  • A nomogram for the prediction of traumatic intracranial abnormalities in the elderly: Development and validation
    Apisorn Jongjit, Thara Tunthanathip
    Chinese Journal of Traumatology.2025;[Epub]     CrossRef
  • Deep learning-based model for detection of intracranial waveforms with poor brain compliance in southern Thailand
    Thara Tunthanathip, Avika Trakulpanitkit
    Acute and Critical Care.2025; 40(3): 473.     CrossRef
  • Prognostic value of CT scoring systems and a simplified prediction model in pediatric moderate-to-severe traumatic brain injury
    Yangyang Diao, Ping Liang
    Chinese Journal of Traumatology.2025;[Epub]     CrossRef
  • Feasibility comparison of deep learning image regressions to estimate intracranial pressure from cranial computed tomography in hydrocephalus
    Thara Tunthanathip, Rakkrit Duangsoithong, Sakchai Sae-Heng
    Journal of Neurosciences in Rural Practice.2025; 16: 606.     CrossRef
  • Risk factors and dose-response relationship of catheter-associated urinary tract infection in neurosurgical patients
    Thara Tunthanathip, Natthanee Pisitthaworakul
    International Journal of Nutrition, Pharmacology, Neurological Diseases.2025; 15(4): 451.     CrossRef
  • Prognosis of subarachnoid hemorrhage determined by intracranial pressure thresholds
    Thara Tunthanathip, Rakkrit Duangsoithong, Sakchai Sae-Heng
    Journal of Cerebrovascular and Endovascular Neurosurgery.2025; 27(4): 309.     CrossRef
  • Prognostic factors and clinical nomogram for in-hospital mortality in traumatic brain injury
    Thara Tunthanathip, Nakornchai Phuenpathom, Apisorn Jongjit
    The American Journal of Emergency Medicine.2024; 77: 194.     CrossRef
  • Development of a Clinical Nomogram for Predicting Shunt-Dependent Hydrocephalus
    Avika Trakulpanitkit, Thara Tunthanathip
    Journal of Health and Allied Sciences NU.2024; 14(04): 516.     CrossRef
  • Prediction performance of the machine learning model in predicting mortality risk in patients with traumatic brain injuries: a systematic review and meta-analysis
    Jue Wang, Ming Jing Yin, Han Chun Wen
    BMC Medical Informatics and Decision Making.2023;[Epub]     CrossRef
  • Development and internal validation of a nomogram to predict massive blood transfusions in neurosurgical operations
    Kanisorn Sungkaro, Chin Taweesomboonyat, Anukoon Kaewborisutsakul
    Journal of Neurosciences in Rural Practice.2022; 13: 711.     CrossRef
  • Prediction of massive transfusions in neurosurgical operations using machine learning
    Chin Taweesomboonyat, Anukoon Kaewborisutsakul, Kanisorn Sungkaro
    Asian Journal of Transfusion Science.2022;[Epub]     CrossRef
Review Article
Neurosurgery
Brain-lung interaction: a vicious cycle in traumatic brain injury
Ariana Alejandra Chacón-Aponte, Érika Andrea Durán-Vargas, Jaime Adolfo Arévalo-Carrillo, Iván David Lozada-Martínez, Maria Paz Bolaño-Romero, Luis Rafael Moscote-Salazar, Pedro Grille, Tariq Janjua
Acute Crit Care. 2022;37(1):35-44.   Published online February 11, 2022
DOI: https://doi.org/10.4266/acc.2021.01193
  • 40,981 View
  • 1,363 Download
  • 46 Web of Science
  • 50 Crossref
AbstractAbstract PDF
The brain-lung interaction can seriously affect patients with traumatic brain injury, triggering a vicious cycle that worsens patient prognosis. Although the mechanisms of the interaction are not fully elucidated, several hypotheses, notably the “blast injury” theory or “double hit” model, have been proposed and constitute the basis of its development and progression. The brain and lungs strongly interact via complex pathways from the brain to the lungs but also from the lungs to the brain. The main pulmonary disorders that occur after brain injuries are neurogenic pulmonary edema, acute respiratory distress syndrome, and ventilator-associated pneumonia, and the principal brain disorders after lung injuries include brain hypoxia and intracranial hypertension. All of these conditions are key considerations for management therapies after traumatic brain injury and need exceptional case-by-case monitoring to avoid neurological or pulmonary complications. This review aims to describe the history, pathophysiology, risk factors, characteristics, and complications of brain-lung and lung-brain interactions and the impact of different old and recent modalities of treatment in the context of traumatic brain injury.

Citations

Citations to this article as recorded by  
  • Recent advances in hydrogel therapy for traumatic brain injury
    Zheng Zou, Mengjia Chen, Jun Liu, Huan Ma, Guobiao Liang, Jingyuan Li
    Colloids and Surfaces B: Biointerfaces.2026; 260: 115424.     CrossRef
  • A nomogram for predicting the risk of acute respiratory distress syndrome in patients with severe acute brain injury
    Qiaoqiao You, Chang Su, Jianping Ye, Miaomiao Chen, JunLong Xu, Xian Zhang, Wen Hu
    BMC Neurology.2026;[Epub]     CrossRef
  • The brain-lung axis: bridging neurological and respiratory disorders via neural-immune-microbial dialogue
    Wenpei Yang, Xiaoyu Shi, Lizheng Xie, Hao Zhang, Lina Shen, Li Pan, Shi Feng, Xiang Mao, Xiao Wu
    Chinese Journal of Traumatology.2026;[Epub]     CrossRef
  • Development and validation of nomogram for predicting neurogenic pulmonary edema in hypertensive intracerebral hemorrhage
    Yajuan Xu, Yinxian Shi
    Frontiers in Cardiovascular Medicine.2026;[Epub]     CrossRef
  • Structural characteristics of the lungs in experimental inertial traumatic brain injury and endotoxinemia
    S. V. Zinoviev, V. B. Shumatov, N. G. Plekhova
    Pacific Medical Journal.2026; (4): 5.     CrossRef
  • Prognostic Factors Associated with Pneumonia in Patients with Traumatic Brain Injury: A Systematic Review and Meta-analysis
    Talia Mia Bitonti, Kevin M. Durr, Bram Rochwerg, Shannon Fernando, Shane English, Hilary Meggison, Dalibor Kubelik, David Neilipovitz, Scott Millington, Alexis F. Turgeon, Francois Lauzier, Naisan Garraway, Donald E. Griesdale, Paul Engels, Alexandre Tran
    Neurocritical Care.2026;[Epub]     CrossRef
  • The lung-brain axis: elucidating the mechanisms of pulmonary-driven neurological disorders
    Longfei Wang, Fei Wang, Xingjun Wang, Xiangning Chen, Chengwei Li, Kaiyue Shan, Haipeng Zhou, Guanzhao Wu, Zhipeng Xu, Xiangyi Kong, Penghui Wei
    Journal of Neuroinflammation.2026;[Epub]     CrossRef
  • Analysis of pathogen distribution and sTREM-1 and miR-126 levels in patients with pulmonary infection after craniocerebral injury
    Lei Gu, Yun Zhen, Zhenlin Huang, Tianbao Chen, Fuxiong Li, Kaipeng Chen
    Technology and Health Care.2025; 33(1): 157.     CrossRef
  • Dynamic pathophysiological features of early primary blast lung injury: a novel functional incapacity pig model
    Shifeng Shao, Shasha Wu, Jun Liu, Zhikang Liao, Pengfei Wu, Yuan Yao, Zhen Wang, Liang Zhang, Yaoli Wang, Hui Zhao
    European Journal of Trauma and Emergency Surgery.2025;[Epub]     CrossRef
  • Extracranial Effects of Traumatic Brain Injury: A Narrative Review
    Nathan K. Evanson, Pratyusha Veldhi, Caitlyn Scherpenberg, John M. Riccobono, Haitham Eid, Jennifer L. McGuire
    Clinics and Practice.2025; 15(3): 47.     CrossRef
  • Review of Ventilation in Traumatic Brain Injury
    Ellen R. Becker, Gregory C. Wetmore, Michael D. Goodman, Dario Rodriquez, Richard D. Branson
    Respiratory Care.2025; 70(4): 450.     CrossRef
  • Does helmet CPAP reduce carotid flow compared to oronasal mask CPAP? A randomized cross-over trial in healthy subjects
    Andrea Duca, Laura Frosio, Luca Molinero, Andrea Finazzi, Ivan Oppedisano, Carlo Bellazzi, Giovanni Nattino, Fabiola Signorini, Guido Bertolini, Eugenia Belotti, Roberto Cosentini
    Internal and Emergency Medicine.2025; 20(8): 2559.     CrossRef
  • Directional interactions from non-small cell lung cancer to brain glucose metabolism revealed by total-body PET imaging
    Tianzheng Zhong, Yanhua Duan, Kun Li, Jianfeng Qiu, Zhaoping Cheng, Weizhao Lu
    European Journal of Nuclear Medicine and Molecular Imaging.2025; 52(12): 4467.     CrossRef
  • Challenges in Pulmonary Management after Traumatic Brain and Spinal Cord Injury
    Xiaofei Zhou, Adam Hwan Bates, Alan Hoffer
    Neurosurgery Clinics of North America.2025; 36(3): 355.     CrossRef
  • Multilevel risk analysis of postoperative pulmonary complications following mandibular fractures: a retrospective cohort study based on patient characteristics and healthcare system factors
    Shuwei Liao, Guanxiong Zhu, Liting Zeng, Yang Yu, Zeyu Zhang, Hongru Zhang, Jingyuan Wang, Lina Yu
    BMC Oral Health.2025;[Epub]     CrossRef
  • Admission braden scale is an effective marker for predicting pneumonia in critically ill patients with traumatic brain injury
    Xuelian Meng, Xia Li, Zhihong Tang
    Neurosurgical Review.2025;[Epub]     CrossRef
  • Does pneumonia increase the risk of dementia and cognitive decline? A systematic review and meta-analysis
    Zhen Yan, Min Zhang, Lifang Yu, Fulian Zhang
    Annals of Medicine.2025;[Epub]     CrossRef
  • Utility of Serum Occludin as a Prognostic Biomarker of Severe Traumatic Brain Injury and Mediation Role of Acute Lung Injury: A Two-Center Prospective Cohort Study
    Shaojun Zhang, Xiufeng Ye, Mi Guo, Yidong Jin, Xuebo Zhang, Jiehao Tu, Jing Huang, Zhiqiang Lian, Fangfang You, Han Zhang
    International Journal of General Medicine.2025; Volume 18: 3525.     CrossRef
  • Association between traumatic brain injury and risk of developing infections in the central nervous system and periphery
    Cristiano Julio Faller, Amanda C. S. Kursancew, Beatriz Brandão Lima, Nicole Golombieski Duarte, Júlia Torcelli Noetzold, Natalli Studnicka, Khiany Mathias, Fabricia Petronilho, Emilio Luiz Streck, Jaqueline S. Generoso
    Metabolic Brain Disease.2025;[Epub]     CrossRef
  • Quercetin attenuates acute lung injury after intracerebral hemorrhage in rats via PI3K/AKT/NF-κB-mediated anti-inflammatory mechanisms
    Heng Xin, Yong-Hui Lv, Zheng-Ting Qian, Qi-Xian Li, Xiang Li, Yong Tang, Yan Shi, He-Ming Wu
    Journal of Radiation Research and Applied Sciences.2025; 18(3): 101732.     CrossRef
  • Predictors of Survival in Patients With Severe Traumatic Brain Injury Undergoing Extracorporeal Membrane Oxygenation
    Wardah Rafaqat, Yasmin Arda, Zoha Z. Fazal, May Abiad, Emanuele Lagazzi, Vahe S. Panossian, Ikemsinachi C. Nzenwa, Haytham M.A. Kaafarani, George C. Velmahos, Michael P. DeWane, Benjamin C. Renne
    Journal of Surgical Research.2025; 313: 526.     CrossRef
  • Lung-brain axis-generated inflammatory biomarkers in traumatic brain injury and acute respiratory distress syndrome: Role of mechanical ventilation/stress
    Nathan H. Johnson, Nancy G. Casanova, Susannah Patarroyo-White, Jason Canizales, Sara M. Camp, Jon Perez Barcena, Juan Pablo de Rivero Vaccari, Bellal Joseph, Joe G.N. Garcia
    Advances in Biomarker Sciences and Technology.2025; 7: 238.     CrossRef
  • From Brain to Lung: Emerging Insights into Mesenchymal Stem Cell-Derived Extracellular Vesicle-Associated Cargos in Ischemia-Reperfusion Injury
    Yiqing Zhang, Xiaodong Shi, Shuang Li, Shi Yan, Lyu Mei, Yuchen Zou, Chunhua Yan
    Journal of Inflammation Research.2025; Volume 18: 11645.     CrossRef
  • Pathophysiology and clinical applications of PEEP in acute brain injury
    Ida Giorgia Iavarone, Patricia Rieken Macedo Rocco, Domenico Luca Grieco, Tommaso Rosà, Mariangela Pellegrini, Rafael Badenes, Robert D. Stevens, Karim Asehnoune, Chiara Robba, Luigi Camporota, Antoine Roquilly
    Intensive Care Medicine.2025; 51(11): 2104.     CrossRef
  • Development and Validation of an Interpretable Machine Learning Model for Predicting venous Thromboembolism in ICU patients With Traumatic Brain Injury: A Multicenter Study
    Hao Qi, Lingli Li, Juan Fang, Tianwei Pei, Ao Li, Zhisong Ding, Tao Chen
    World Neurosurgery.2025; 202: 124399.     CrossRef
  • Brain Protective Ventilation Strategies in Severe Acute Brain Injury
    Sarah Al Sharie, Rahma Almari, Saif Azzam, Lou’i Al-Husinat, Mohammad Araydah, Denise Battaglini, Marcus J. Schultz, Nicolo’ Antonino Patroniti, Patricia RM Rocco, Chiara Robba
    Current Neurology and Neuroscience Reports.2025;[Epub]     CrossRef
  • Dynamic nomogram for predicting early tracheotomy in patients diagnosed with supratentorial deep seated intracranial hemorrhage
    Chubin Liu, Suqiong Yang, Gang Wang, Jiayin Wang, Liangqin Luo, Yasong Li
    Frontiers in Neurology.2025;[Epub]     CrossRef
  • Glymphatic Dysfunction in Neuro-Pulmonary Complications Following Subarachnoid Hemorrhage: A New Perspective on Brain–Lung Axis Disruption
    Eun Chae Lee, Jae Sang Oh
    Cells.2025; 14(21): 1739.     CrossRef
  • Epidemiology and Outcomes of Battlefield-Related Penetrating and Closed Traumatic Brain Injuries Compared to Non-Head Injuries: A Retrospective Cohort Study
    Melissa R Meister, Jason H Boulter, Callum D Dewar, Caren Stuebe, Erica Sercy, M Leigh Carson, Faraz Shaikh, Joseph M Yabes, Laveta Stewart, David R Tribble, Viktor Bartanusz, Bradley Dengler
    Military Medicine.2025;[Epub]     CrossRef
  • Early Prediction of Acute Respiratory Distress Syndrome in Critically Ill Polytrauma Patients Using Balanced Random Forest ML: A Retrospective Cohort Study
    Nesrine Ben El Hadj Hassine, Sabri Barbaria, Omayma Najah, Halil İbrahim Ceylan, Muhammad Bilal, Lotfi Rebai, Raul Ioan Muntean, Ismail Dergaa, Hanene Boussi Rahmouni
    Journal of Clinical Medicine.2025; 14(24): 8934.     CrossRef
  • Uncertainty in Neurocritical Care: Recognizing Its Relevance for Clinical Decision-Making
    Luis Rafael Moscote-Salazar, William A. Florez-Perdomo, Tariq Janjua
    Indian Journal of Neurotrauma.2024; 21(01): 092.     CrossRef
  • Manejo postoperatorio de resección de tumores cerebrales en la unidad de cuidado intensivo
    Andrés Felipe Naranjo Ramírez, Álvaro de Jesús Medrano Areiza, Bryan Arango Sánchez, Juan Carlos Arango Martínez, Luis Fermín Naranjo Atehortúa
    Acta Colombiana de Cuidado Intensivo.2024; 24(2): 140.     CrossRef
  • Effects of positive end-expiratory pressure on intracranial pressure, cerebral perfusion pressure, and brain oxygenation in acute brain injury: Friend or foe? A scoping review
    Greta Zunino, Denise Battaglini, Daniel Agustin Godoy
    Journal of Intensive Medicine.2024; 4(2): 247.     CrossRef
  • Acute brain injury increases pulmonary capillary permeability via sympathetic activation-mediated high fluid shear stress and destruction of the endothelial glycocalyx layer
    Na Zhao, Chao Liu, Xinxin Tian, Juan Yang, Tianen Wang
    Experimental Cell Research.2024; 434(2): 113873.     CrossRef
  • Oral administration of lysozyme protects against injury of ileum via modulating gut microbiota dysbiosis after severe traumatic brain injury
    Weijian Yang, Caihua Xi, Haijun Yao, Qiang Yuan, Jun Zhang, Qifang Chen, Gang Wu, Jin Hu
    Frontiers in Cellular and Infection Microbiology.2024;[Epub]     CrossRef
  • Pulmonary Effects of Traumatic Brain Injury in Mice: A Gene Set Enrichment Analysis
    Wei-Hung Chan, Shih-Ming Huang, Yi-Lin Chiu
    International Journal of Molecular Sciences.2024; 25(5): 3018.     CrossRef
  • Beyond the brain: General intensive care considerations in pediatric neurocritical care
    Thao L. Nguyen, Dennis W. Simon, Yi-Chen Lai
    Seminars in Pediatric Neurology.2024; 49: 101120.     CrossRef
  • Research Progress of Hemorrhagic Stroke Combined with Stroke-Associated Pneumonia
    松 刘
    Advances in Clinical Medicine.2024; 14(05): 2336.     CrossRef
  • The Impact of Pulmonary Disorders on Neurological Health (Lung-Brain Axis)
    Hongryeol Park, Chan Hee Lee
    Immune Network.2024;[Epub]     CrossRef
  • Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
    Jong-Tae Kim, Kang Song, Sung Woo Han, Dong Hyuk Youn, Harry Jung, Keun-Suh Kim, Hyo-Jung Lee, Ji Young Hong, Yong-Jun Cho, Sung-Min Kang, Jin Pyeong Jeon
    Cell & Bioscience.2024;[Epub]     CrossRef
  • Standard versus individualised positive end-expiratory pressure (PEEP) compared by electrical impedance tomography in neurocritical care: a pilot prospective single centre study
    Vera Spatenkova, Mikulas Mlcek, Alan Mejstrik, Lukas Cisar, Eduard Kuriscak
    Intensive Care Medicine Experimental.2024;[Epub]     CrossRef
  • Perioperative Ventilation in Neurosurgical Patients: Considerations and Challenges
    Ida Giorgia Iavarone, Patricia R.M. Rocco, Pedro Leme Silva, Shaurya Taran, Sarah Wahlster, Marcus J. Schultz, Nicolo’ Antonino Patroniti, Chiara Robba
    Current Anesthesiology Reports.2024; 14(4): 512.     CrossRef
  • Ventilatory targets following brain injury
    Shaurya Taran, Sarah Wahlster, Chiara Robba
    Current Opinion in Critical Care.2023; 29(2): 41.     CrossRef
  • Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain
    Jia Nong, Patrick M. Glassman, Jacob W. Myerson, Viviana Zuluaga-Ramirez, Alba Rodriguez-Garcia, Alvin Mukalel, Serena Omo-Lamai, Landis R. Walsh, Marco E. Zamora, Xijing Gong, Zhicheng Wang, Kartik Bhamidipati, Raisa Y. Kiseleva, Carlos H. Villa, Colin F
    ACS Nano.2023; 17(14): 13121.     CrossRef
  • Modulation of MAPK/NF-κB Pathway and NLRP3 Inflammasome by Secondary Metabolites from Red Algae: A Mechanistic Study
    Asmaa Nabil-Adam, Mohamed L. Ashour, Mohamed Attia Shreadah
    ACS Omega.2023; 8(41): 37971.     CrossRef
  • American Association for the Surgery of Trauma/American College of Surgeons Committee on Trauma clinical protocol for management of acute respiratory distress syndrome and severe hypoxemia
    Jason A. Fawley, Christopher J. Tignanelli, Nicole L. Werner, George Kasotakis, Samuel P. Mandell, Nina E. Glass, David J. Dries, Todd W. Costantini, Lena M. Napolitano
    Journal of Trauma and Acute Care Surgery.2023; 95(4): 592.     CrossRef
  • The role of cardiac dysfunction and post-traumatic pulmonary embolism in brain-lung interactions following traumatic brain injury
    Mabrouk Bahloul, Karama Bouchaala, Najeh Baccouche, Kamilia Chtara, Hedi Chelly, Mounir Bouaziz
    Acute and Critical Care.2022; 37(2): 266.     CrossRef
  • Allocation of Donor Lungs in Korea
    Hye Ju Yeo
    Journal of Chest Surgery.2022; 55(4): 274.     CrossRef
  • Mapping brain endophenotypes associated with idiopathic pulmonary fibrosis genetic risk
    Ali-Reza Mohammadi-Nejad, Richard J. Allen, Luke M. Kraven, Olivia C. Leavy, R. Gisli Jenkins, Louise V. Wain, Dorothee P. Auer, Stamatios N. Sotiropoulos
    eBioMedicine.2022; 86: 104356.     CrossRef
  • Use of bedside ultrasound in the evaluation of acute dyspnea: a comprehensive review of evidence on diagnostic usefulness
    Ivan David Lozada-Martinez, Isabela Zenilma Daza-Patiño, Gerardo Jesus Farley Reina-González, Sebastián Rojas-Pava, Ailyn Zenith Angulo-Lara, María Paola Carmona-Rodiño, Olga Gissela Sarmiento-Najar, Jhon Mike Romero-Madera, Yesid Alonso Ángel-Hernandez
    Revista Investigación en Salud Universidad de Boyacá.2022;[Epub]     CrossRef
Original Articles
Basic science and research
A machine learning model for predicting favorable outcome in severe traumatic brain injury patients after 6 months
Mehdi Nourelahi, Fardad Dadboud, Hosseinali Khalili, Amin Niakan, Hossein Parsaei
Acute Crit Care. 2022;37(1):45-52.   Published online January 21, 2022
DOI: https://doi.org/10.4266/acc.2021.00486
  • 10,234 View
  • 296 Download
  • 16 Web of Science
  • 17 Crossref
AbstractAbstract PDF
Background
Traumatic brain injury (TBI), which occurs commonly worldwide, is among the more costly of health and socioeconomic problems. Accurate prediction of favorable outcomes in severe TBI patients could assist with optimizing treatment procedures, predicting clinical outcomes, and result in substantial economic savings.
Methods
In this study, we examined the capability of a machine learning-based model in predicting “favorable” or “unfavorable” outcomes after 6 months in severe TBI patients using only parameters measured on admission. Three models were developed using logistic regression, random forest, and support vector machines trained on parameters recorded from 2,381 severe TBI patients admitted to the neuro-intensive care unit of Rajaee (Emtiaz) Hospital (Shiraz, Iran) between 2015 and 2017. Model performance was evaluated using three indices: sensitivity, specificity, and accuracy. A ten-fold cross-validation method was used to estimate these indices.
Results
Overall, the developed models showed excellent performance with the area under the curve around 0.81, sensitivity and specificity of around 0.78. The top-three factors important in predicting 6-month post-trauma survival status in TBI patients are “Glasgow coma scale motor response,” “pupillary reactivity,” and “age.”
Conclusions
Machine learning techniques might be used to predict the 6-month outcome in TBI patients using only the parameters measured on admission when the machine learning is trained using a large data set.

Citations

Citations to this article as recorded by  
  • Development of web- and mobile-based shared decision-making tools in the neurological intensive care unit
    Winnie L. Liu, Lidan Zhang, Soussan Djamasbi, Bengisu Tulu, Susanne Muehlschlegel
    Neurotherapeutics.2025; 22(1): e00503.     CrossRef
  • Long-term survival prediction in patients with acute brain lesions using ensemble machine learning algorithms: a cohort study with combined national health insurance service and its self-run hospital database
    Dougho Park, Daeyoung Hong, Suntak Jin, Jong Hun Kim, Hyoung Seop Kim
    Journal of Big Data.2025;[Epub]     CrossRef
  • Predicting outcomes after moderate and severe traumatic brain injury using artificial intelligence: a systematic review
    Armaan K. Malhotra, Husain Shakil, Christopher W. Smith, Yu Qing Huang, Jethro C. C. Kwong, Kevin E. Thorpe, Christopher D. Witiw, Abhaya V. Kulkarni, Jefferson R. Wilson, Avery B. Nathens
    npj Digital Medicine.2025;[Epub]     CrossRef
  • Artificial intelligence in traumatic brain injury: Brain imaging analysis and outcome prediction: A mini review
    Luca Marino, Federico Bilotta
    World Journal of Critical Care Medicine.2025;[Epub]     CrossRef
  • Prediction of Clinically Significant Improvements During the Interdisciplinary Intensive Outpatient Program for Traumatic Brain Injury Using Machine Learning
    Rujirutana Srikanchana, David Samuel, Jacob Powell, Treven Pickett, Thomas DeGraba, Chandler Sours Rhodes
    Annals of Biomedical Engineering.2025; 53(11): 2845.     CrossRef
  • A practical approach to predicting long-term outcomes in traumatic brain injury: Enhancing clinical decision-making with machine learning
    Amirmohammad Farrokhi, Mahtab Jalali, Mohamed Sobhi Jabal, Saeed Abdollahifard, Reza Taheri, Omid Yousefi, Amin Niakan, Hosseinali Khalili
    Computers in Biology and Medicine.2025; 196: 110827.     CrossRef
  • The effect of extended early rehabilitation on the treatment outcome of patients with moderate and severe traumatic brain injury
    Nataša Keleman, Dragana Dragičević-Cvjetković, Aleksandra Mikov, Dragomir Radošević, Ðula Ðilvesi, Vladimir Mrđa, Rastislava Krasnik
    Frontiers in Human Neuroscience.2025;[Epub]     CrossRef
  • Artificial Intelligence in Traumatic Brain Injury: A Systematic Review of Prognostic, Diagnostic, and Monitoring Applications
    Anas E Ahmed, Rayan M Alyami, Fatimah H Al Ghazwi, Renad H Hamzi, Nawa K Alshammari, Fawziah M Jali, Abdullah A Al Alduwayh, Thikra M Almujami, Abdullah S Alamri, Jamal A Sabban, Ghadi F Alsum
    Cureus.2025;[Epub]     CrossRef
  • Enhancing hospital course and outcome prediction in patients with traumatic brain injury: A machine learning study
    Guangming Zhu, Burak B Ozkara, Hui Chen, Bo Zhou, Bin Jiang, Victoria Y Ding, Max Wintermark
    The Neuroradiology Journal.2024; 37(1): 74.     CrossRef
  • Machine Learning in Neuroimaging of Traumatic Brain Injury: Current Landscape, Research Gaps, and Future Directions
    Kevin Pierre, Jordan Turetsky, Abheek Raviprasad, Seyedeh Mehrsa Sadat Razavi, Michael Mathelier, Anjali Patel, Brandon Lucke-Wold
    Trauma Care.2024; 4(1): 31.     CrossRef
  • A Systematic Review of the Outcomes of Utilization of Artificial Intelligence Within the Healthcare Systems of the Middle East: A Thematic Analysis of Findings
    Mohsen Khosravi, Seyyed Morteza Mojtabaeian, Emine Kübra Dindar Demiray, Burak Sayar
    Health Science Reports.2024;[Epub]     CrossRef
  • Science fiction or clinical reality: a review of the applications of artificial intelligence along the continuum of trauma care
    Olivia F. Hunter, Frances Perry, Mina Salehi, Hubert Bandurski, Alan Hubbard, Chad G. Ball, S. Morad Hameed
    World Journal of Emergency Surgery.2023;[Epub]     CrossRef
  • Gastrointestinal failure, big data and intensive care
    Pierre Singer, Eyal Robinson, Orit Raphaeli
    Current Opinion in Clinical Nutrition & Metabolic Care.2023; 26(5): 476.     CrossRef
  • Prediction performance of the machine learning model in predicting mortality risk in patients with traumatic brain injuries: a systematic review and meta-analysis
    Jue Wang, Ming Jing Yin, Han Chun Wen
    BMC Medical Informatics and Decision Making.2023;[Epub]     CrossRef
  • Predicting return to work after traumatic brain injury using machine learning and administrative data
    Helena Van Deynse, Wilfried Cools, Viktor-Jan De Deken, Bart Depreitere, Ives Hubloue, Eva Kimpe, Maarten Moens, Karen Pien, Ellen Tisseghem, Griet Van Belleghem, Koen Putman
    International Journal of Medical Informatics.2023; 178: 105201.     CrossRef
  • Fluid-Based Protein Biomarkers in Traumatic Brain Injury: The View from the Bedside
    Denes V. Agoston, Adel Helmy
    International Journal of Molecular Sciences.2023; 24(22): 16267.     CrossRef
  • Predicting Outcome in Patients with Brain Injury: Differences between Machine Learning versus Conventional Statistics
    Antonio Cerasa, Gennaro Tartarisco, Roberta Bruschetta, Irene Ciancarelli, Giovanni Morone, Rocco Salvatore Calabrò, Giovanni Pioggia, Paolo Tonin, Marco Iosa
    Biomedicines.2022; 10(9): 2267.     CrossRef
Trauma
Prevalence and clinical impact of vitamin D deficiency in critically ill Korean patients with traumatic injuries: a single-center, prospective, observational study
Kyoung Hoon Lim, Jihoon Jang, Jinyoung Park
Acute Crit Care. 2021;36(2):92-98.   Published online April 29, 2021
DOI: https://doi.org/10.4266/acc.2020.00801
  • 6,832 View
  • 145 Download
AbstractAbstract PDF
Background
This study investigated the prevalence and impact of 25-hydroxyvitamin D (25(OH) vitamin D) deficiency in critically ill Korean patients with traumatic injuries.
Methods
This prospective observational cohort study assessed the 25(OH) vitamin D status of consecutive trauma patients admitted to the trauma intensive care unit (TICU) of Kyungpook National University Hospital between January and December 2018. We analyzed the prevalence of 25(OH) vitamin D deficiency and its impact on clinical outcomes.
Results
There were no significant differences in the duration of mechanical ventilation (MV), lengths of TICU and hospital stays, and rates of nosocomial infection and mortality between patients with 25(OH) vitamin D <20 ng/ml and those with 25(OH) vitamin D ≥20 ng/ml within 24 hours of TICU admission. The duration of MV and lengths of TICU and hospital stays were shorter and the rate of nosocomial infection was lower in patients with 25(OH) vitamin D level ≥20 ng/ml on day 7 of hospitalization. The duration of MV, lengths of TICU and hospital stays, and nosocomial infection rate were significantly lower in patients with increased concentrations compared with those with decreased concentrations on day 7 of hospitalization, but the mortality rate did not differ significantly.
Conclusions
The 25(OH) vitamin D level measured within 24 hours after TICU admission was unrelated to clinical outcomes in critically ill patients with traumatic injuries. However, patients with increased 25(OH) vitamin D level after 7 days of hospitalization had better clinical outcomes than those with decreased levels.
Trauma
The association between the initial lactate level and need for massive transfusion in severe trauma patients with and without traumatic brain injury
Young Hoon Park, Dong Hyun Ryu, Byung Kook Lee, Dong Hun Lee
Acute Crit Care. 2019;34(4):255-262.   Published online November 29, 2019
DOI: https://doi.org/10.4266/acc.2019.00640
  • 8,267 View
  • 147 Download
  • 8 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Background
Exsanguination is a major cause of death in severe trauma patients. The purpose of this study was to analyze the prognostic impact of the initial lactate level for massive transfusion (MT) in severe trauma. We divided patients according to subgroups of traumatic brain injury (TBI) and non-TBI.
Methods
This single-institution retrospective study was conducted on patients who were admitted to hospital for severe trauma between January 2016 and December 2017. TBI was defined by a head Abbreviated Injury Scale ≥3. Receiver operating characteristic analysis was used to analyze the prognostic impact of the lactate level. Multivariate analyses were performed to evaluate the relationship between the MT and lactate level. The primary outcome was MT.
Results
Of the 553 patients, MT was performed in 62 patients (11.2%). The area under the curve (AUC) for the lactate level for predicting MT was 0.779 (95% confidence interval [CI], 0.742 to 0.813). The AUCs for lactate level in the TBI and non-TBI patients were 0.690 (95% CI, 0.627 to 0.747) and 0.842 (95% CI, 0.796 to 0.881), respectively. In multivariate analyses, the lactate level was independently associated with the MT (odds ratio [OR], 1.179; 95% CI, 1.070 to 1.299). The lactate level was independently associated with MT in non-TBI patients (OR, 1.469; 95% CI, 1.262 to 1.710), but not in TBI patients.
Conclusions
The initial lactate level may be a possible prognostic factor for MT in severe trauma. In TBI patients, however, the initial lactate level was not suitable for predicting MT.

Citations

Citations to this article as recorded by  
  • Near-Field Communications Sensor for Lactate Determination in Saliva and Sweat Using Organic Electrochemical Transistors (OECTs)
    Antonio Lazaro, Emma Rojas Rodriguez, Marc Lazaro, Ramon Villarino, Benito González, David Girbau
    IEEE Sensors Journal.2026; 26(3): 5037.     CrossRef
  • Agreement of point‐of‐care and laboratory lactate levels among trauma patients and association with transfusion
    Biswadev Mitra, Madison Essery, Abha Somesh, Carly Talarico, Alexander Olaussen, David Anderson, Benjamin Meadley
    Vox Sanguinis.2025; 120(2): 188.     CrossRef
  • A Combined Model of Vital Signs and Serum Biomarkers Outperforms Shock Index in the Prediction of Hemorrhage Control Interventions in Surgical Intensive Care Unit Patients
    John P. Forrester, Manuel Beltran Del Rio, Cristine H. Meyer, Samuel P. R. Paci, Ella R. Rastegar, Timmy Li, Maria G. Sfakianos, Eric N. Klein, Matthew E Bank, Daniel M. Rolston, Nathan A Christopherson, Daniel Jafari
    Journal of Intensive Care Medicine.2025; 40(6): 632.     CrossRef
  • Association of initial lactate levels and red blood cell transfusion strategy with outcomes after severe trauma: a post hoc analysis of the RESTRIC trial
    Yoshinori Kosaki, Takashi Hongo, Mineji Hayakawa, Daisuke Kudo, Shigeki Kushimoto, Takashi Tagami, Hiromichi Naito, Atsunori Nakao, Tetsuya Yumoto
    World Journal of Emergency Surgery.2024;[Epub]     CrossRef
  • Predictors of massive transfusion protocols activation in patients with trauma in Korea: a systematic review
    Dongmin Seo, Inhae Heo, Juhong Park, Junsik Kwon, Hye-min Sohn, Kyoungwon Jung
    Journal of Trauma and Injury.2024; 37(2): 97.     CrossRef
  • Prehospital Lactate Levels Obtained in the Ambulance and Prediction of 2-Day In-Hospital Mortality in Patients With Traumatic Brain Injury
    Francisco Martin-Rodriguez, Ancor Sanz-Garcia, Raul Lopez-Izquierdo, Juan F. Delgado Benito, Francisco T. Martínez Fernández, Santiago Otero de la Torre, Carlos Del Pozo Vegas
    Neurology.2024;[Epub]     CrossRef
Trauma
Usefulness of Rotational Thromboelastometry as a Mortality Predictor of Hyperfibrinolysis in Patients with Severe Trauma
Ji Soo Kim, Il Jae Wang, Seok Ran Yeom, Suck Ju Cho, Jae Hun Kim, June Pill Seok, Seong Hwa Lee, Byung Gwan Bae, Mun Ki Min
Acute Crit Care. 2018;33(3):162-169.   Published online August 31, 2018
DOI: https://doi.org/10.4266/acc.2018.00199
  • 11,072 View
  • 204 Download
  • 8 Web of Science
  • 9 Crossref
AbstractAbstract PDF
Background
Hemorrhage is the major cause of traumatic death and the leading cause of preventable death. Hyperfibrinolysis is associated with trauma severity. Viscoelastic hemostatic assays show complete clot formation dynamics. The present study was designed to identify the relationship between hyperfibrinolysis and mortality, metabolic acidosis, and coagulopathy in patients with trauma.
Methods
Patients with severe trauma (injury severity score [ISS] of 15 or higher) who were assessed using rotational thromboelastometry (ROTEM) were included in the present study from January 2017 to December 2017. Variables were obtained from the Korea Trauma Database or the medical charts of the patients. To identify whether hyperfibrinolysis is an independent predictor of mortality, univariate and multivariate Cox regression analyses were performed.
Results
During the 1-year study period, 190 patients were enrolled. In total, 21 (11.1%) had hyperfibrinolysis according to the ROTEM analysis and 46 (24.2%) died. Patients with hyperfibrinolysis had a higher ISS (P=0.014) and mortality rate (P<0.001) than did those without hyperfibrinolysis. In multivariate Cox analysis, hyperfibrinolysis (hazard ratio [HR], 4.960; 95% confidence interval [CI], 2.447 to 10.053), age (HR, 1.033; 95% CI, 1.013 to 1.055), lactic acid level (HR, 1.085; 95% CI, 1.003 to 1.173), and ISS (HR, 1.037; 95% CI, 1.004 to 1.071) were independent predictors of mortality.
Conclusions
Hyperfibrinolysis is associated with increased mortality, worse metabolic acidosis, and severe coagulopathy and is an independent predictor of mortality in patients with trauma.

Citations

Citations to this article as recorded by  
  • Paraneoplastic Hyperfibrinolysis in Oesophageal Adenocarcinoma: A Case Report
    Yuhui Zhou, William Gelson, Rebecca Brais, Martin Besser
    Cureus.2025;[Epub]     CrossRef
  • Prognostic value of admission ROTEM in trauma: enhancing 30-day all-cause mortality prediction using machine learning
    Villiam V. Kildal, Martin Dahlberg, Carl Henrik Ek, Anders Oldner, Agneta Wikman, Carl Magnus Wahlgren, Mattias Günther
    European Journal of Trauma and Emergency Surgery.2025;[Epub]     CrossRef
  • Exploring the interchangeable roles of fibrinogen and FIBTEM in patients with sepsis
    Hanh-Duyen Bui-Thi, Tuan-Anh Nguyen, Khoa Nguyen-Dang, Kien Gia To, Tai Tran-Quoc, Minh-Khoi Le
    Therapeutic Advances in Hematology.2025;[Epub]     CrossRef
  • A comparative analysis of tranexamic acid dosing strategies in traumatic major hemorrhage
    Finn Gunn, Rheanna Stevenson, Ateeq Almuwallad, Andrea Rossetto, Paul Vulliamy, Karim Brohi, Ross Davenport
    Journal of Trauma and Acute Care Surgery.2024; 96(2): 216.     CrossRef
  • A retrospective validation of ROTEM algorithms for detecting hyperfibrinolysis demonstrates poor agreement for prediction of in-hospital mortality and transfusion requirement in a general, non-cardiac, surgical population
    Leon Rosebery, Matthew Miller, Peter Loizou, Shir Jing Ho, Keith J. Adkins, Kush Deshpande
    Thrombosis Research.2023; 229: 170.     CrossRef
  • Questions about COVID-19 associated coagulopathy: possible answers from the viscoelastic tests
    Vittorio Pavoni, Lara Gianesello, Maddalena Pazzi, Pietro Dattolo, Domenico Prisco
    Journal of Clinical Monitoring and Computing.2022; 36(1): 55.     CrossRef
  • Clinical value of early assessment of hyperfibrinolysis by rotational thromboelastometry during postpartum hemorrhage for the prediction of severity of bleeding: A multicenter prospective cohort study in the Netherlands
    Marije Tahitu, Paul I. Ramler, Ada Gillissen, Camila Caram‐Deelder, Dacia D. C. A. Henriquez, Moniek P. M. de Maat, Johannes J. Duvekot, Jeroen Eikenboom, Kitty W. M. Bloemenkamp, Thomas van den Akker, Johanna G. van der Bom
    Acta Obstetricia et Gynecologica Scandinavica.2022; 101(1): 145.     CrossRef
  • ROTEM diagnostic capacity for measuring fibrinolysis in neonatal sepsis
    Maria Lampridou, Rozeta Sokou, Andreas G. Tsantes, Martha Theodoraki, Aikaterini Konstantinidi, Georgios Ioakeimidis, Stefanos Bonovas, Marianna Politou, Serena Valsami, Zoe Iliodromiti, Theodora Boutsikou, Nicoletta Iacovidou, Georgios Nikolopoulos, Argi
    Thrombosis Research.2020; 192: 103.     CrossRef
  • The Immunologic Effect of Early Intravenous Two and Four Gram Bolus Dosing of Tranexamic Acid Compared to Placebo in Patients With Severe Traumatic Bleeding (TAMPITI): A Randomized, Double-Blind, Placebo-Controlled, Single-Center Trial
    Philip C. Spinella, Kimberly A. Thomas, Isaiah R. Turnbull, Anja Fuchs, Kelly Bochicchio, Douglas Schuerer, Stacey Reese, Adrian A. Coleoglou Centeno, Christopher B. Horn, Jack Baty, Susan M. Shea, M. Adam Meledeo, Anthony E. Pusateri, Jerrold H. Levy, An
    Frontiers in Immunology.2020;[Epub]     CrossRef
Trauma
Acute Physiology and Chronic Health Evaluation II Score and Sequential Organ Failure Assessment Score as Predictors for Severe Trauma Patients in the Intensive Care Unit
Min A Lee, Kang Kook Choi, Byungchul Yu, Jae Jeong Park, Youngeun Park, Jihun Gwak, Jungnam Lee, Yang Bin Jeon, Dae Sung Ma, Gil Jae Lee
Korean J Crit Care Med. 2017;32(4):340-346.   Published online November 30, 2017
DOI: https://doi.org/10.4266/kjccm.2017.00255
  • 13,415 View
  • 199 Download
  • 13 Web of Science
  • 12 Crossref
AbstractAbstract PDF
Background
The Acute Physiology and Chronic Health Evaluation (APACHE) II scoring system and the Sequential Organ Failure Assessment (SOFA) scoring system are widely used for critically ill patients. We evaluated whether APACHE II score and SOFA score predict the outcome for trauma patients in the intensive care unit (ICU).
Methods
We retrospectively analyzed trauma patients admitted to the ICU in a single trauma center between January 2014 and December 2015. The APACHE II score was figured out based on the data acquired from the first 24 hours of admission; the SOFA score was evaluated based on the first 3 days in the ICU. A total of 241 patients were available for analysis. Injury Severity score, APACHE II score, and SOFA score were evaluated.
Results
The overall survival rate was 83.4%. The non-survival group had a significantly high APACHE II score (24.1 ± 8.1 vs. 12.3 ± 7.2, P < 0.001) and SOFA score (7.7 ± 1.7 vs. 4.3 ± 1.9, P < 0.001) at admission. SOFA score had the highest areas under the curve (0.904). During the first 3 days, SOFA score remained high in the non-survival group. In the non-survival group, cardiovascular system, neurological system, renal system, and coagulation system scores were significantly higher.
Conclusions
In ICU trauma patients, both SOFA and APACHE II scores were good predictors of outcome, with the SOFA score being the most effective. In trauma ICU patients, the trauma scoring system should be complemented, recognizing that multi-organ failure is an important factor for mortality.

Citations

Citations to this article as recorded by  
  • Nutritional compliance as a prognostic and quality indicator in the intensive care unit: Insights from nutrition support team–guided therapy
    Soo-Hyun Park, Jung Hwan Lee, Jongbeom Shin, Sunmin Lee, Jae Won Lee, Hyunjin Ju, Jeong-Yoon Lee, Kyungbok Lee
    Nutrition.2026; 142: 112962.     CrossRef
  • Development and validation of a machine learning model to predict 30-day mortality in ischemic stroke patients with consciousness impairment: Insights from MIMIC-IV database and multicenter ICU data in China
    Yupei Cheng, Yang Guo, Yusheng Zhao, Chaoran Wang, Xiaoling Zhao, Qiuhua Yu, Jingjie Huang, Yuxing Zhang, Jingsha Zhang, Xixian Liu, Pan Cai, Chao Zhang, Bangqi Wu, Yi Guo
    International Journal of Medical Informatics.2026; 207: 106203.     CrossRef
  • Comparison of Braden Score vs APACHE to Predict Occurrence of Bed Sores in a Tertiary Care ICU
    Sandeep Dewan, Munish Chauhan, Khuram Maqbool
    Indian Journal of Critical Care Medicine.2025; 29(2): 164.     CrossRef
  • Comparison of Serum Phosphate Levels in Critically Ill Patients with Acute Kidney Injury Undergoing Continuous Renal Replacement Therapy Using Different Dialysates
    Moo Jun Kim, Hae Ri Kim, Young Rok Ham, Jae Wan Jeon
    Journal of Kidney Diseases.2025; 19(02): 106.     CrossRef
  • Comparison of APACHE II and APACHE IV Scores in Predicting Mortality in the Surgical ICU (SICU) of a Tertiary Care Hospital - A Prospective Study
    Prashanta Swami Pujar, Pavithra P, Sachin ., Prajwal RK
    International Journal of Health Sciences and Research.2025; : 192.     CrossRef
  • Identification of TRIM52 as a potential biomarker in mortality risk assessment in patients with sepsis
    Ke Wang, Zhubin Yang, Chun Xiang Wu, Ju Cao
    Human Immunology.2024; 85(6): 111174.     CrossRef
  • Clinical significance of lactate-to-albumin ratio in patients with influenza A virus-induced acute respiratory distress syndrome: a single-center retrospective study
    Jinhui Gao, Xuanzhe Yang, Xiang Fang, Ziyi Zhang, Dapeng Wang, Jiajia Wang
    BMC Anesthesiology.2024;[Epub]     CrossRef
  • ATENDIMENTO PRÉ-HOSPITALAR AO TRAUMA E SEU DESFECHO INTRA-HOSPITALAR EM 72 HORAS
    Paulo Philip de Abreu Gonzaga, Thiago Queiroz de Souza, Bárbara Juliana Carvalho Costa, Ivany Rolim Vinhote Teixeira, Gisele Torrente
    Enfermagem em Foco.2024;[Epub]     CrossRef
  • Cell-free DNA as diagnostic and prognostic biomarkers for adult sepsis: a systematic review and meta-analysis
    Awirut Charoensappakit, Kritsanawan Sae-khow, Pongpera Rattanaliam, Nuntanuj Vutthikraivit, Monvasi Pecheenbuvan, Suwasin Udomkarnjananun, Asada leelahavanichkul
    Scientific Reports.2023;[Epub]     CrossRef
  • Evaluation of the sequential organ failure assessment score and newly introduced criteria – Traumasis - in traffic collision patients
    Sion Jo, Taeoh Jeong, Boyoung Park
    The American Journal of Emergency Medicine.2022; 51: 98.     CrossRef
  • Predictive value of Modified Early Warning Score (MEWS) and Revised Trauma Score (RTS) for the short-term prognosis of emergency trauma patients: a retrospective study
    Zhejun Yu, Feng Xu, Du Chen
    BMJ Open.2021; 11(3): e041882.     CrossRef
  • Risk factors for abdominal surgical site infection after exploratory laparotomy among combat casualties
    Joseph D. Bozzay, Patrick F. Walker, David W. Schechtman, Faraz Shaikh, Laveta Stewart, M. Leigh Carson, David R. Tribble, Carlos J. Rodriguez, Matthew J. Bradley
    Journal of Trauma and Acute Care Surgery.2021; 91(2S): S247.     CrossRef
Case Reports
Trauma/Surgery
Secondary Abdominal Compartment Syndrome Recognized in Operating Room in Severely Injured Patients
Seok Hwa Youn, John Cook-Jong Lee, Kyoungwon Jung, Jonghwan Moon, Yo Huh, Younghwan Kim
Korean J Crit Care Med. 2016;31(1):58-62.   Published online February 29, 2016
DOI: https://doi.org/10.4266/kjccm.2016.31.1.58
  • 35,661 View
  • 98 Download
AbstractAbstract PDF
For trauma patients with severe shock, massive fluid resuscitation is necessary. However, shock and a large amount of fluid can cause bowel and retroperitoneal edema, which sometimes leads to abdominal compartment syndrome in patients without abdomino-pelvic injury. If other emergent operations except intraabdomen are needed, a distended abdomen is likely to be recognized late, leading to multiple organ dysfunction. Herein, we report two cases of a 23-year-old woman who was in a car accident and a 53-year old man who was pressed on his leg by a pressing machine; severe brain swelling and popliteal vessel injury were diagnosed, respectively. They were both in severe shock and massive fluid resuscitation was required in the emergency department. Distended abdomen was recognized in both the female and male patients immediately after neurosurgical operation and immediately before orthopaedic operation in the operating room, respectively. Decompressive laparotomy revealed massive ascites with retroperitoneal edema.
Cardiology/Thoracic surgery
The Use of Extracorporeal Membrane Oxygenation in the Surgical Repair of Bronchial Rupture
Ju-Hee Park, Junghyeon Lim, Jaejin Lee, Hee Sung Lee
Korean J Crit Care Med. 2016;31(1):54-57.   Published online February 29, 2016
DOI: https://doi.org/10.4266/kjccm.2016.31.1.54
  • 6,248 View
  • 84 Download
AbstractAbstract PDF
Extracorporeal membrane oxygenation (ECMO) has been used successfully in critically ill patients with traumatic lung injury and offers an additional treatment modality. ECMO is mainly used as a bridge treatment to delayed surgical management; however, only a few case reports have presented the successful application of ECMO as intraoperative support during the surgical repair of traumatic bronchial injury. A 38-year-old man visited our hospital after a blunt chest trauma. His chest imaging showed hemopneumothorax in the left hemithorax and a finding suspicious for left main bronchus rupture. Bronchoscopy was performed and confirmed a tear in the left main bronchus and a congenital tracheal bronchus. We decided to provide venovenous ECMO support during surgery for bronchial repair. We successfully performed main bronchial repair in this traumatic patient with a congenital tracheal bronchus. We suggest that venovenous ECMO offers a good option for the treatment of bronchial rupture when adequate ventilation is not possible.
Vascular surgery
Endovascular Treatment of Proximal Superior Mesenteric Artery Pseudoaneurysm after Stab Injury
Dong Hun Kim, Young-Wook Kim, Kwang Bo Park
Korean J Crit Care Med. 2015;30(4):354-357.   Published online November 30, 2015
DOI: https://doi.org/10.4266/kjccm.2015.30.4.354
  • 8,458 View
  • 96 Download
AbstractAbstract PDF
Superior mesenteric artery (SMA) injuries remain a challenge to most trauma surgeons and continue to result in significant mortality despite aggressive management. We report successful management of a proximal SMA injury through endovascular treatment in a 56-year-old man. The patient presented with hypotension due to a stab wound after the epigastrium. He underwent emergency laparotomy and repair of the penetrated wall of the stomach. Right retroperitoneal hematoma at the initial laparotomy expanded and ruptured, requiring a massive transfusion. At the second laparotomy, we performed lateral arteriorrhaphy of the proximal SMA. Follow-up abdominal computed tomography angiography on post-injury day 7 showed a pseudoaneurysm on the left side of the SMA trunk. The patient was treated successfully with an endovascular stent graft.
Neurosurgery
Delayed Traumatic Subarachnoid Hemorrhage in a Polytraumatized Patient with Disseminated Intravascular Coagulation
Jiwoong Oh, Wonyeon Lee, Ji Young Jang, Pilyoung Jung, Sohyun Kim, Jongyeon Kim, Jinsu Pyen, Kum Whang, Sungmin Cho
Korean J Crit Care Med. 2015;30(4):336-342.   Published online November 30, 2015
DOI: https://doi.org/10.4266/kjccm.2015.30.4.336
  • 12,717 View
  • 149 Download
  • 1 Crossref
AbstractAbstract PDF
The precise mechanism involved in DIC and delayed traumatic subarachnoid hemorrhage (DT-SAH) remains unclear in multipletrauma patients. Hereby, we describe a polytraumatized patient with DIC who died due to DT-SAH. A 75-year-old female patient was admitted to our Emergency Department complaining of abdominal pain and drowsiness after a pedestrian accident. Her initial brain computerized tomography (CT) finding was negative for intracranial injury. However, her abdominal CT scan revealed a collection of retroperitoneal hematomas from internal iliac artery bleeding after a compressive pelvic fracture. This event eventually resulted in shock and DIC. An immediate angiographic embolization of the bleeding artery was performed along with transfusion and antithrombin III. Her vital signs were stabilized without neurological change. Fourteen hours after admission, she suddenly became comatose, and her follow-up brain CT scan revealed a dense DT-SAH along the basal cisterns with acute hydrocephalus. This event rapidly prompted brain CT angiography and digital subtraction angiography, which both confirmed the absence of any cerebrovascular abnormality. Despite emergency extraventricular drainage to reverse the hydrocephalus, the patient died three days after the trauma. This paper presents an unusual case of DT-SAH in a polytraumatized patient with DIC.

Citations

Citations to this article as recorded by  
  • Is initial optic nerve sheath diameter prognostic of specific head injury in emergency departments?
    Bedriye Müge Sönmez, Emirhan Temel, Murat Doğan İşcanlı, Fevzi Yılmaz, Uğur Gülöksüz, Selçuk Parlak, Özhan Merzuk Uçkun
    Journal of the National Medical Association.2019; 111(2): 210.     CrossRef
Pulmonary
Barotrauma after Manual Ventilation in a Patient with Life-Threatening Massive Hemoptysis
Hea Yon Lee, Yu Young Joo, Young Seung Oh, Yoo Rim Seo, Hyon Soo Joo, Seok Chan Kim, Chin Kook Rhee
Korean J Crit Care Med. 2015;30(4):308-312.   Published online November 30, 2015
DOI: https://doi.org/10.4266/kjccm.2015.30.4.308
  • 13,127 View
  • 131 Download
  • 3 Crossref
AbstractAbstract PDF
A 36-year-old female patient with aplastic anemia developed massive hemoptysis and was placed on ventilator support. However, airway obstruction by blood clots triggered desaturation and ventilator malfunction. Manual ventilation was initiated to improve oxygenation, and emergency flexible bronchoscopy was performed to clear the airway. Nevertheless, the patient developed extensive subcutaneous emphysema, pneumothorax, and pneumomediastinum.

Citations

Citations to this article as recorded by  
  • Clinical Approach to Massive Hemoptysis: Perioperative Focus on Causes and Management
    Timothy Weiquan Toh, Jacqueline Hui Fen Goh, Sui An Lie, Carrie Kah Lai Leong, Nian Chih Hwang
    Journal of Cardiothoracic and Vascular Anesthesia.2024; 38(10): 2412.     CrossRef
  • Pathophysiology and Prevention of Manual-Ventilation-Induced Lung Injury (MVILI)
    Luke A. White, Steven A. Conrad, Jonathan Steven Alexander
    Pathophysiology.2024; 31(4): 583.     CrossRef
  • Experimental validation of a portable tidal volume indicator for bag valve mask ventilation
    Benjamin S. Maxey, Luke A. White, Giovanni F. Solitro, Steven A. Conrad, J. Steven Alexander
    BMC Biomedical Engineering.2022;[Epub]     CrossRef
Trauma/Vascular surgery
Resuscitative Endovascular Balloon Occlusion of the Aorta in a Trauma Patient with Hypovolemic Shock
Hong Kyung Shin, Ho-Seong Han, Taeseung Lee, Do-Joong Park, Kyuwhan Jung, Kyuseok Kim
Korean J Crit Care Med. 2015;30(2):115-118.   Published online May 31, 2015
DOI: https://doi.org/10.4266/kjccm.2015.30.2.115
  • 20,664 View
  • 101 Download
  • 3 Crossref
AbstractAbstract PDF
Hemorrhagic shock is one of the most common causes of death in patients with multiple trauma and therefore rapid control of bleeding is the main strategy to save these patients. Resuscitative balloon occlusion of the aorta (REBOA) has been applied in several trauma cases and because of the effectiveness of this procedure it has been adopted in the trauma field. Herein, we report the first successful case of REBOA in Korea performed on a 46-year-old man with hemorrhagic shock after a fall from a height of 14-stories. The patient visited our hospital emergency room with hypovolemic shock, we performed Resuscitative Endovascular Balloon Occlusion of the Aorta under bed side blind technique. His vital sign was stabilized after procedure, then we could performed endovascular bleeding control. The patient was discharged on his 33rd in-hospital day without invasive procedure and major scar.

Citations

Citations to this article as recorded by  
  • Nurses’ Knowledge Regarding Management of Hypovolemic Shock: A Cross-Sectional Study
    Maher Atiyah
    Academia Open.2024;[Epub]     CrossRef
  • Implementation of resuscitative endovascular balloon occlusion of the aorta at the Korean Regional Trauma Center
    Youngeun Park, Byungchul Yu, Giljae Lee, Jungnam Lee, Kangkook Choi, Ahram Han
    Hong Kong Journal of Emergency Medicine.2021; 28(3): 129.     CrossRef
  • Case Series of Zone III Resuscitative Endovascular Balloon Occlusion of the Aorta in Traumatic Shock Patients
    Byungchul Yu, Gil Jae Lee, Kang Kook Choi, Min A Lee, Jihun Gwak, Youngeun Park, Jung Nam Lee
    Journal of Trauma and Injury.2020; 33(3): 162.     CrossRef
Cardiology/Thoracic surgery
Cardiac Rupture of the Junction of the Right Atrium and Superior Vena Cava in Blunt Thoracic Trauma
Chun Sung Byun, Il Hwan Park, Tae Hoon Kim, Eunbi Lee, Joong Hwan Oh
Korean J Crit Care Med. 2015;30(1):27-30.   Published online February 28, 2015
DOI: https://doi.org/10.4266/kjccm.2015.30.1.27
  • 8,749 View
  • 93 Download
AbstractAbstract PDF
Cardiac rupture following blunt thoracic trauma is rarely encountered, since it commonly causes death at the scene. With advances in critical care, blunt cardiac rupture has been successfully treated with well-organized team approach including an emergency physician, anesthesiologist, and cardiac surgeon. We encountered a patient with blunt cardiac rupture of the junction of the superior vena cava and right atrium that extended 7 cm to the right ventricular junction. The patient was successfully resuscitated after a closed thoracostomy and pericardiocentesis with fluid loading. Cardiac injury was repaired via mid-sternotomy without cardiopulmonary bypass. The patient recovered without complications and was discharged on the 7th day after surgery.
Cardiology/Pulmonary
Complicated Pulmonary Pseudocyst Following Traumatic Lung Injury Rescued by Extracorporeal Membrane Oxygenation
Sung Bum Park, Dae Sang Lee, Jeong Am Ryu, Jong Ho Cho, Yang Hyun Cho, Chi Ryang Chung, Jeong Hoon Yang, Kyeongman Jeon, Gee Young Suh, Chi Min Park
Korean J Crit Care Med. 2014;29(3):201-206.   Published online August 31, 2014
DOI: https://doi.org/10.4266/kjccm.2014.29.3.201
  • 7,960 View
  • 57 Download
AbstractAbstract PDF
Traumatic pulmonary pseudocyst is a rare complication of blunt chest trauma that usually appears immediately in children or young adults and is characterized by a single or multiple pulmonary cystic lesions on chest radiography and has spontaneous resolution of the radiologic manifestations. However, we experienced a case of a delayed complicated pulmonary pseudocyst in a 17-year-old boy following severe traumatic acute respiratory distress syndrome rescued by Veno-venous extracorporeal membrane oxygenation (ECMO). In this case, the pseudocyst appeared on the 12th day after trauma and transformed into an infected cyst. Veno-venous ECMO was successfully maintained for 20 days without anticoagulation.
Review Article
Pharmacology
Assessment and Treatment of Pain in Adult Intensive Care Unit Patients
Jun Mo Park, Ji Hyun Kim
Korean J Crit Care Med. 2014;29(3):147-159.   Published online August 31, 2014
DOI: https://doi.org/10.4266/kjccm.2014.29.3.147
  • 27,051 View
  • 806 Download
  • 3 Crossref
AbstractAbstract PDF
In most cases, patients admitted to an intensive care unit (ICU) have suffered from severe trauma, undergone major surgery or been treated for a serious medical illness. Although they often experience more intense pain than general ward patients, they are frequently unable to communicate their experiences to health care providers, thus preventing accurate assessment and treatment of their pain. If appropriate measures are not taken to treat pain in critically ill patients, stress response or sympathetic overstimulation can lead to complications. The short-term consequences of untreated pain include higher energy expenditure and immunomodulation. Longer-term, untreated pain increases the risk of post-traumatic stress disorder. Because pain is quite subjective, the accurate assessment of pain is very difficult in the patients with impaired communication ability. The current most valid and reliable behavioral pain scales used to assess pain in adult ICU patients are the Behavioral Pain Scale and the Critical-Care Pain Observation Tool. Once pain has been accurately assessed using these methods, various pharmacologic and non-pharmacologic therapies should be performed by the multidisciplinary care team. Accurate assessment and proper treatment of pain in adult ICU patients will improve patients outcome, which reduces the stress response and decreases the risk of post-traumatic stress disorder.

Citations

Citations to this article as recorded by  
  • Nurses’ knowledge, practice, and associated factors of pain assessment in critically ill adult patients at public hospitals, Addis Ababa, Ethiopia
    Temesgen Ayenew, Berhanu Melaku, Mihretie Gedfew, Haile Amha, Keralem Anteneh Bishaw
    International Journal of Africa Nursing Sciences.2021; 15: 100361.     CrossRef
  • Impact of Pain Management Algorithm on Pain Intensity of Patients with Loss of Consciousness Hospitalized in Intensive Care Unit: A Clinical Trial
    Zahra Dehghani, Asadollah Keikhaei, Fariba Yaghoubinia, Aliakbar Keykha, Masoom Khoshfetrat
    Medical - Surgical Nursing Journal.2019;[Epub]     CrossRef
  • Ignorance may be Bliss (for Intensivists), but not for ICU Patients!
    Atul P. Kulkarni, Sumitra G Bakshi
    Indian Journal of Critical Care Medicine.2019; 23(4): 161.     CrossRef
Original Article
Trauma
Mortality and Morbidity in Severely Traumatized Elderly Patients
Byungchul Yu, Min Chung, Giljae Lee, Jungnam Lee
Korean J Crit Care Med. 2014;29(2):88-92.   Published online May 31, 2014
DOI: https://doi.org/10.4266/kjccm.2014.29.2.88
  • 7,162 View
  • 71 Download
  • 4 Crossref
AbstractAbstract PDF
Background
As the population ages, the elderly will constitute a prominent proportion of trauma patients. The elderly suffer more severe outcomes from injuries compared with the young. In this study, we examined the relationship between mortality and complications with age.
Methods
This study was a retrospective review of 256 major trauma patients (Injury Severity Score > 15) admitted to an emergency center over a two- year period. Age-dependent mortality and complications were evaluated.
Results
Of 256 patients, 209 (81.6%) were male and the mean age was 47.2 years. There was a trend between increasing age and increasing mortality, but this was not statistically significant. Increasing age was correlated with frequency of complications.
Conclusions
Age was confirmed to be an independent predictor of mortality in major trauma. We documented that elderly trauma patients suffer from complications more frequently compared with their younger counterparts. Appropriate and specific triage and management guidelines for elderly trauma patients are needed.

Citations

Citations to this article as recorded by  
  • Predicting mortality in elderly trauma patients: a review of the current literature
    Jarva Chow, Catherine M. Kuza
    Current Opinion in Anaesthesiology.2022; 35(2): 160.     CrossRef
  • Activities of Daily Living and Determinant Factors among Older Adult Subjects with Lower Body Fracture after Discharge from Hospital: A Prospective Study
    Nurul Izzah Ibrahim, Mohd Sharkawi Ahmad, Mohamed S Zulfarina, Sharifah Nurul Aqilah Sayed Mohd Zaris, Isa Naina Mohamed, Norazlina Mohamed, Sabarul Afian Mokhtar, Ahmad Nazrun Shuid
    International Journal of Environmental Research and Public Health.2018; 15(5): 1002.     CrossRef
  • Geriatric Trauma Protocol
    Renee Cortez
    Journal of Trauma Nursing.2018; 25(4): 218.     CrossRef
  • Predictive Factors of Dependency in Activities of Daily Living Following Limb Trauma in the Elderly
    Azade Safa, Negin Masoudi Alavi, Masoumeh Abedzadeh-Kalahroudi
    Trauma Monthly.2016;[Epub]     CrossRef
Case Reports
Blunt Splenic Injury by Gunshot
Young Hoon Sul, Sang Il Lee, Kwang Sik Cheon, Jae Young Moon, Jun Wan Lee, In Sang Song
Korean J Crit Care Med. 2013;28(4):340-343.
DOI: https://doi.org/10.4266/kjccm.2013.28.4.340
  • 3,835 View
  • 39 Download
AbstractAbstract PDF
Trauma is frequently not purely penetrating or purely blunt. Such mixed trauma can result from the mechanism of injury. Recently, we encountered a patient who accidentally shot himself with a shotgun. He had a 15 x 8-cm-sized penetrating injury on left flank that did not penetrate into the peritoneal cavity and a blunt splenic injury with hemoperitoneum. Surgical and interventional treatments were performed for each injury. We present this case with a review of the related literature.
A Chronic Traumatic Diaphragmatic Hernia Presenting 36 Years after Preceding Injury: A Case Report
Kyung Hwa Kim, Ja Hong Kuh, Tae Yoon Kim
Korean J Crit Care Med. 2010;25(3):199-202.
DOI: https://doi.org/10.4266/kjccm.2010.25.3.199
  • 3,085 View
  • 73 Download
AbstractAbstract PDF
We report a distinctive case of a large traumatic diaphragmatic hernia (TDH) that presented 36-years after the preceding injury. We believe this case represents the most delayed (TDH) presentation ever reported in Korea. This paper describes the particular presentation, including the operative and postoperative management of this patient. We also review the management of long delayed TDH presentation and the postoperative issues concerning thoracic cavity dead space and propensity of the repaired diaphragm for developing abdominal compartment syndrome.
Delayed Splenic Rupture with a 1-month Latent Period after Minor Trauma: A Case Report
Jong Seok Lee, Oh Young Kwon, Han Sung Choi, Hoon Pyo Hong, Young Gwan Ko
Korean J Crit Care Med. 2010;25(2):104-106.
DOI: https://doi.org/10.4266/kjccm.2010.25.2.104
  • 4,465 View
  • 47 Download
  • 1 Crossref
AbstractAbstract PDF
Delayed splenic rupture is a rare complication of blunt abdominal trauma in which the time interval from injury to splenic rupture is > 48 hours. The diagnosis can be challenging if the history of trauma is remote, or initially missed, because symptoms may present subtly and without classic historical associations. We report a case of delayed rupture of the spleen from remote, minor trauma that required an emergency splenectomy.

Citations

Citations to this article as recorded by  
  • Delayed splenic rupture presenting 70 days following blunt abdominal trauma
    Nancy Resteghini, Jonpaul Nielsen, Matthew L. Hoimes, Adib R. Karam
    Clinical Imaging.2014; 38(1): 73.     CrossRef
ACC : Acute and Critical Care
© The Korean Society of Critical Care Medicine.
TOP