Acute and Critical Care

Review Article

Basic science and research
Extracorporeal circulation models in small animals: beyond the limits of preclinical research: Mukhammad Kayumov, Reverien Habimana, Dowan Kim, Francis O Obiweluozor, In Seok Jeong, Hwa Jin Cho; Acute Crit Care. 2023;38(1):1-7. Published online February 28, 2023; DOI: https://doi.org/10.4266/acc.2023.00381

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Extracorporeal membrane oxygenation (ECMO) use has remarkably increased in recent years. Although ECMO has become essential for patients with refractory cardiac and respiratory failure, extracorporeal circulation (ECC) is associated with significant complications. Small-animal models of ECC have been developed and widely used to better understand ECC-induced pathophysiology. This review article summarizes the development of small-animal ECC models, including the animal species, circuit configuration, priming, perioperative procedures, cannulation, and future perspectives of small-animal ECMO models.

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A systematic review of adult animal models investigating ECMO use for ARDS: where to from here
Muhtadi Alnababteh, Xizhong Cui, Mark Jeakle, Yan Li, Nancy Terry, Tom Gamble, Junfeng Sun, Shreya Kanth, Peter Q. Eichacker, Parizad Torabi-Parizi
Intensive Care Medicine Experimental.2025;[Epub] CrossRef
A Miniaturized Centrifugal Pump ECMO System Enhances Hemocompatibility in Small Animal Models
Zhen Yang, Yiai Li, Jingyi Peng, Danhe Jia, Youpeng Zhang, Wenxing Huo, Zhigang Liu, Xian Huang
Biotechnology Journal.2025;[Epub] CrossRef
Reversal of ACLF and ALF using whole blood extracorporeal system combining HLA-depleted liver organoids with granulocyte-monocyte apheresis
Hitomi Yamaguchi, Yosuke Yoneyama, Kentaro Ichimura, Kanae Ohtsu, Mika Soen, Chiharu Moriya, Maki Kumagai, Robert P. Myers, G. Mani Subramanian, Takanori Takebe
Journal of Hepatology.2025;[Epub] CrossRef
Silk-based multilayer coatings for anticoagulation and durability improvement in ECMO hollow fiber membranes
Wenbo Zhang, Yilin Zhang, Chenlu Wang, Xingji Fu, Yuan Li, Hongyu Wang, Xiuyuan Luo, Linhao Li, Yubo Fan, Zengsheng Chen
Acta Biomaterialia.2025; 207: 205. CrossRef
Venoarterial Extracorporeal Membrane Oxygenation Implementation in Septic Shock Rat Model
Tianlong Wang, Mingru Zhang, Wenhao Dong, Jing Wang, Han Zhang, Yuefu Wang, Bingyang Ji
ASAIO Journal.2024; 70(8): 653. CrossRef
Multiorgan recovery in a cadaver body using mild hypothermic ECMO treatment in a murine model
Nodir Madrahimov, Vitalii Mutsenko, Ruslan Natanov, Dejan Radaković, André Klapproth, Mohamed Hassan, Mathias Rosenfeldt, Florian Kleefeldt, Ivan Aleksic, Süleyman Ergün, Christoph Otto, Rainer G. Leyh, Constanze Bening
Intensive Care Medicine Experimental.2023;[Epub] CrossRef
Post-Mortem Extracorporeal Membrane Oxygenation Perfusion Rat Model: A Feasibility Study
Matthias Manfred Deininger, Carl-Friedrich Benner, Lasse Johannes Strudthoff, Steffen Leonhardt, Christian Simon Bruells, Gernot Marx, Christian Bleilevens, Thomas Breuer
Animals.2023; 13(22): 3532. CrossRef

Original Articles

Pediatric
Abstract to publication conversion in pediatric critical care medicine in Pakistan: Anwarul Haque, Mohammad Shahzad, Humaira Jurair, Naveed Ur Rehman Siddiqui, Sidra Ishaque, Qalab Abbas; Acute Crit Care. 2021;36(1):62-66. Published online February 5, 2021; DOI: https://doi.org/10.4266/acc.2020.00780

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Abstract PDF

Background
To determine the rate of conversion of abstracts presented at conferences into full-text articles published in peer-reviewed journals in the field of pediatric critical care medicine (PCCM) in a developing country.
Methods
We retrospectively reviewed PCCM abstracts from Pakistan presented at national and international pediatric and critical care conferences over 10 years (January 2010 to March 2020). Data included abstract characteristics, such as presentation (poster/oral), presenter (fellow/resident), time of meeting (month and year), type of meeting, study design and topic; and publication characteristics, such as journal name, time (month and year) and first author. The primary outcome was publication rate of PCCM abstracts presented in meetings and time (months) from presentation to publication.
Results
A total of 79 PCCM abstracts were presented in 20 meetings during the study period. There were 65 poster presentations (82.28%), of which 63 (79.74%) were presented at international critical care conferences and all presenters were PCCM fellows. In total, 64 (81%) abstracts were descriptive observational studies (retrospective: 50, 63.29%) and prospective (14, 17.72%). Only one was an interventional randomized controlled trial. The publication rate of PCCM abstracts was 63.3% (50/79) and the mean time to publication was 12.39±13.61 months. The publication rate was significantly correlated to the year of publication (P<0.001).
Conclusions
The PCCM abstract publication rate and mean time from presentation to publication was 63.3% and 12.39±13.61 months, respectively, in a developing country.

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From Concept to Publication
Aaron W. Calhoun, Isabel T. Gross, Leah B. Mallory, Lindsay N. Shepard, Mark D. Adler, Tensing Maa, Marc A. Auerbach, Adam Cheng, David O. Kessler, Travis M. Whitfill, Jonathan P. Duff
Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare.2022; 17(6): 385. CrossRef

Nursing
Challenges of the patient transition process from the intensive care unit: a qualitative study: Kobra Ghorbanzadeh, Abbas Ebadi, Mohammadali Hosseini, Sadat Seyed Bagher Madah, Hamidreza Khankeh; Acute Crit Care. 2021;36(2):133-142. Published online January 28, 2021; DOI: https://doi.org/10.4266/acc.2020.00626

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Abstract PDF

Background
The transition of patients from the intensive care unit (ICU) to the general ward is challenging. This study aimed to explain the challenges that patients face during the transition process.
Methods
In this qualitative research of conventional content analysis, data collection was conducted between February 2018 and July 2019 in educational hospitals. After obtaining informed consent, purposive sampling was performed with 22 nurses, intensive care physicians, anesthesiologists, and patients and their families using in-depth semi-structured interviews until data saturation.
Results
The content analysis yielded three main themes in the challenges patients face during the transition process from the ICU: mixed feelings regarding transition (happiness/hope, worry/uncertainty, abandonment); care break (different atmosphere, the difference between the program and the quality of care, assigning care to the patient and family, and care culture and beliefs); and search for support and information (ineffective communication, self-care capacity of patient and family, ineffective and disrupted training, and weak follow-up programs), which inflicts care shock in the patients.
Conclusions
The results showed that patients and their families were in a state of care shock during the ICU transition process and were sometimes disconcerted. It is necessary to design and implement care models according to the needs and challenges patients face during the transition period from ICU (patient-centered), based on the evidence available, and after considering the field of medicine and the accessibility of care in the country. The transition process can be improved and enhanced by obtaining knowledge about ICU care and related challenges as well as organizing a learning environment.

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The Facilitators to Care Transition from Hospital to Home After Stroke: A Qualitative Study
Somayeh Bahadoram, Narges Arsalani, Masoud Fallahi-Khoshknab, Farahnaz Mohammadi-Shahbolaghi, Asghar Dalvandi
Iranian Journal of Nursing and Midwifery Research.2026; 31(1): 161. CrossRef
Contextual Factors Influencing Intensive Care Patients’ Discharge Processes: A Multicentre Prospective Observational Study
Frances Fengzhi Lin, Jacqueline Peet, Lauren Murray, Huahua Yin, Mahesh Ramanan, Kylie Jacobs, Jane Brailsford, Amelia Osmond, Moreblessing Kajevu, Roslyn Prichard, Peter Garrett, Alexis Tabah, Carol Mock, Ahmed Mehdi, Yingyan Chen
Journal of Clinical Nursing.2025; 34(8): 3307. CrossRef
Waiting to be discharged from intensive care units: Key factors shaping patient and family experiences
Yingyan Chen, Jacqueline Peet, Lauren Murray, Mahesh Ramanan, Kylie Jacobs, Jane Brailsford, Amelia Osmond, Moreblessing Kajevu, Peter Garrett, Alexis Tabah, Carol Mock, Frances Fengzhi Lin
Intensive and Critical Care Nursing.2025; 87: 103961. CrossRef
Comprehensive investigation of ergonomic challenges and predictors of work-related musculoskeletal disorders among intensive care unit nurses of Western India through convergent mixed methods study
Sonali Detroja, Rajkumar Mahajan, Ankit Sheth
BMC Musculoskeletal Disorders.2025;[Epub] CrossRef
Exploring the Unique Challenges of ICU‐To‐Ward Transitions for Patients and Families: A Meta‐Synthesis of Qualitative Research
Junru Zhang, Hongting Zhou, Weijing Sui, Yiyu Zhuang, Li Wang
Journal of Advanced Nursing.2025; 81(12): 8579. CrossRef
Caregiver-supported nursing intervention for smoothing the transition from pediatric intensive care units to ward: protocol for a pre-post interventional study
Shramana Ray Panda, Asha P. Shetty, Bhagirathi Dwibedi
International Journal of Research in Medical Sciences.2025; 13(4): 1606. CrossRef
Navigating the shift: a meta-synthesis of patient experiences and challenges in the intensive care unit-to-ward transition
Shramana R. Panda, Asha P. Shetty, Bhagirathi Dwibedi
International Journal Of Community Medicine And Public Health.2025; 12(4): 1864. CrossRef
Incidence and Outcome of Readmission of Surgical Patients to Intensive Care Unit and Associated Factors at Tikur Anbessa Specialized Hospital. Prospective Observational Study
Osman Aman Hamido
Collective Journal Of Surgery.2025; : o1. CrossRef
The relationship between caregiving burden and hospital anxiety and depression in relatives of elderly patients transferred from intensive care unit to the ward
Sevda Turen, Faruk Yildizer
BMC Nursing.2025;[Epub] CrossRef
Nurse‐Led Transfer Programme With Patient Relatives: Effect on Reducing Transfer Anxiety in Intensive Care Unit Patients
Yakup Akyüz, Seda Er, Şahin Bozok, Yasemin Uslu
Nursing in Critical Care.2025;[Epub] CrossRef
ICU Readmission and In-Hospital Mortality Rates for Patients Discharged from the ICU—Risk Factors and Validation of a New Predictive Model: The Worse Outcome Score (WOScore)
Eleftherios Papadakis, Athanasia Proklou, Sofia Kokkini, Ioanna Papakitsou, Ioannis Konstantinou, Aggeliki Konstantinidi, Georgios Prinianakis, Stergios Intzes, Marianthi Symeonidou, Eumorfia Kondili
Journal of Personalized Medicine.2025; 15(10): 479. CrossRef
Development and validation of a prediction model for caregiving unpreparedness among informal caregivers of ICU patients transferred to general wards
Shengnan Kuai, Yuying Fan, Jie Liu, Xin Chen, Qiuyu Liu
Psychology, Health & Medicine.2025; : 1. CrossRef
Experiencias de transición de pacientes y familiares al alta de la terapia intensiva: revisión de alcance
Paula Buchs Zucatti, Clediane Rita Portalupi da Trindade, Rosana Evangelista-Poderoso, Edinêis de Brito Guirardello, Maria Alice Dias da Silva Lima
Revista Latino-Americana de Enfermagem.2025;[Epub] CrossRef
Transition experiences of patients and families upon discharge from intensive care: a scoping review
Paula Buchs Zucatti, Clediane Rita Portalupi da Trindade, Rosana Evangelista-Poderoso, Edinêis de Brito Guirardello, Maria Alice Dias da Silva Lima
Revista Latino-Americana de Enfermagem.2025;[Epub] CrossRef
Experiências de transição de pacientes e familiares na alta da terapia intensiva: revisão de escopo
Paula Buchs Zucatti, Clediane Rita Portalupi da Trindade, Rosana Evangelista-Poderoso, Edinêis de Brito Guirardello, Maria Alice Dias da Silva Lima
Revista Latino-Americana de Enfermagem.2025;[Epub] CrossRef
The dyadic coping experience of ICU transfer patients and their spouses: A qualitative study
Jiayi Gu, He Wang, Jiaqin Pei, Jingyu Meng, Yan Song
Nursing in Critical Care.2024; 29(4): 672. CrossRef
Transition of Intensive Care Unit Patients and Their Families to Home After Acute Hospital Care
HyunBin You, Sharron L. Docherty, Deepshikha C. Ashana, Tolu O. Oyesanya
AACN Advanced Critical Care.2024; 35(2): 97. CrossRef
Experiences of Intensive Care Unit Patients as They Transition to the Ward: A Thematic Synthesis
Li Yumei, Deping Zhang, Yu Xu
Journal of Clinical Nursing.2024; 33(12): 4830. CrossRef
A Quality Improvement Project to Decrease Suboptimal Patient Transfers between Two Neonatal Units
Kiane A. Douglas, Chinonye Eriobu, Ann Sanderson, Dmitry Tumin, Uduak S. Akpan
Pediatric Quality & Safety.2023; 8(1): e635. CrossRef
Patient transfer from intensive care units to general wards: An exploratory qualitative study of ward nurses' experiences of patient safety
Mette Kure Nikolaisen, Stina Fridh, Brita Fosser Olsen
Nursing Open.2023; 10(10): 6769. CrossRef
Exploring factors affecting the timely transition of ventilator assisted individuals in Ontario from acute to long-term care: Perspectives of healthcare professionals
Anne-Marie Selzler, Leanna Lee, Dina Brooks, Raj Kohli, Louise Rose, Roger Goldstein
Canadian Journal of Respiratory Therapy.2023;[Epub] CrossRef
Family caregivers' experiences and needs of transitional care during the transfer from intensive care unit to a general ward: A qualitative study
Yuxin Zhan, Jiaohua Yu, Yi Chen, Yufang Liu, Yingyue Wang, Yali Wan, Suyun Li
Journal of Nursing Management.2022; 30(2): 592. CrossRef
Co-development of a transitions in care bundle for patient transitions from the intensive care unit: a mixed-methods analysis of a stakeholder consensus meeting
Brianna K. Rosgen, Kara M. Plotnikoff, Karla D. Krewulak, Anmol Shahid, Laura Hernandez, Bonnie G. Sept, Jeanna Morrissey, Kristin Robertson, Nancy Fraser, Daniel J. Niven, Sharon E. Straus, Jeanna Parsons Leigh, Henry T. Stelfox, Kirsten M. Fiest
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Dietetic-Led Nutrition Interventions in Patients with COVID-19 during Intensive Care and Ward-Based Rehabilitation: A Single-Center Observational Study
Ella Terblanche, Jessica Hills, Edie Russell, Rhiannon Lewis, Louise Rose
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Factors Influencing the Decision-making of Healthcare Providers Regarding the Transition of Patients from the Intensive Care Unit to the General Ward in Iran: A Qualitative Study
Vahid Adiban, Kobra Ghorbanzadeh, Abbas Ebadi, Mohammadali Hosseini, Sadat Seyed Bagher Maddah, Hamidreza Khankeh, Maryam Khoshbakht Pishkhani
Indian Journal of Critical Care Medicine.2022; 26(5): 568. CrossRef
Validação de manual para complementar a transição de cuidados na alta da terapia intensiva
Martina Zucchetti, Isis Marques Severo, Isabel Cristina Echer, Daniela dos Santos Marona Borba, Carmen Lucia Silva Nectoux, Karina de Oliveira Azzolin
Revista Gaúcha de Enfermagem.2022;[Epub] CrossRef
Validation of manual to complement the transition of care at discharge from intensive care
Martina Zucchetti, Isis Marques Severo, Isabel Cristina Echer, Daniela dos Santos Marona Borba, Carmen Lucia Silva Nectoux, Karina de Oliveira Azzolin
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Basic science and research
Specification of Subject Sex in Oncology-Related Animal Studies: Sukyo Lee, Won Jun Kim, Yeong Jeon, Choon Hak Lim, Kyung Sun; Acute Crit Care. 2018;33(3):178-184. Published online August 31, 2018; DOI: https://doi.org/10.4266/acc.2017.00444

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Abstract PDF

Background
Growing evidence for clinically significant differences between the sexes has attracted the attention of researchers. However, failures to report a test animal sex and balance the sex ratios of study samples remain widespread in preclinical investigations. We analyzed the sex-reporting rate and sex distributions of test animals in published oncology studies.
Methods
We selected five oncology journals included in the Scientific Citation Index (SCI) based on impact factors. We identified preclinical investigations with in vivo mouse experiments published in 2015 for inclusion in our study sample. We classified each article by whether or not it reported test subject sex, and by which sex was included. We also recorded whether there were justifications for using one particular sex in single-sex studies (e.g., anatomical reasons) and whether sex-based analyses were conducted for both-sex studies.
Results
We surveyed a total of 382 articles. Half (50.3%) failed to report test animal sex. Among articles that did report sex, 91.7% were single-sex studies, of which 69.4% did not provide any justifications for using the sex included in the study. Relatively few studies 15.7 studies included animals of both sexes, and only 2.3 studies conducted sex-based analyses. These findings are consistent with those of previous research that used other methods to collect data from the literature such as text mining, but our analysis of the provision of justifications for using one sex versus the other is a novel feature.
Conclusions
Many researchers overlook test subject sex as a factor, but test animal sex should be reported in all preclinical investigations to enhance the reproducibility of research and avoid faulty conclusions drawn from one-sided studies.

Citations

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Pyrimethamine reduced tumour growth in pre-clinical cancer models: a systematic review to identify potential pre-clinical studies for subsequent human clinical trials
Sivananthan Manoharan, Lee Ying Ying
Biology Methods and Protocols.2024;[Epub] CrossRef

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