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Original Article
- Trauma
- Role of platelet-to-lymphocyte ratio at the time of arrival to the emergency room as a predictor of short-term mortality in trauma patients with severe trauma team activation
- Jae Kwang Kim, Kyung Hoon Sun
- Acute Crit Care. 2024;39(1):146-154. Published online February 15, 2024
- DOI: https://doi.org/10.4266/acc.2023.01319
- 12,316 View
- 306 Download
- 6 Web of Science
- 8 Crossref
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Abstract
PDF - Background
Platelet-to-Lymphocyte ratio (PLR) has been studied as a prognostic factor for various diseases and traumas. This study examined the utility of PLR as a tool for predicting 30-day mortality in patients experiencing severe trauma.
Methods
This study included 139 patients who experienced trauma and fulfilled ≥1 criteria for activation of the hospital’s severe trauma team. Patients were divided into non-survivor and survivor groups. Mean PLR values were compared between the groups, the optimal PLR cut-off value was determined, and mortality and survival analyses were performed. Statistical analyses were performed using SPSS ver. 26.0. The threshold of statistical significance was P<0.05.
Results
There was a significant difference in mean (±standard deviation) PLR between the non-survivor (n=36) and survivor (n=103) groups (53.4±30.1 vs. 89.9±53.3, respectively; P<0.001). Receiver operating characteristic (ROC) curve analysis revealed an optimal PLR cut-off of 65.35 (sensitivity, 0.621; specificity, 0.694, respectively; area under the ROC curve, 0.742), and Kaplan-Meier survival analysis revealed a significant difference in mortality rate between the two groups.
Conclusions
PLR can be calculated quickly and easily from a routine complete blood count, which is often performed in the emergency department for individuals who experience trauma. The PLR is useful for predicting 30-day mortality in trauma patients with severe trauma team activation. -
Citations
Citations to this article as recorded by
- Key laboratory changes in severe trauma, a different pattern for each clinical phenotype
Adrián Marcos-Morales, Jesús Abelardo Barea Mendoza, Marcos Valiente Fernández, Carlos García Fuentes, Fernando Calvo Boyero, Cecilia Cueto-Felgueroso, Judith Gutiérrez Gutiérrez, Francisco de Paula Delgado Moya, Carolina Mudarra Reche, Susana Bermejo Azn
Medicina Intensiva (English Edition).2026; 50(4): 502227. CrossRef - Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Combined with Model for End-Stage Liver Disease 3.0 as a Prognostic Predictor for Patients with Liver Cirrhosis after Transjugular Intrahepatic Portosystemic Shunt Creation
Takeshi Suzuki, Kenkichi Michimoto, Kentaro Yamada, Khashayar Farsad
Journal of Vascular and Interventional Radiology.2026; 37(2): 107922. CrossRef - Stabilized C-reactive protein–albumin–lymphocyte (CALLY) index predicts adjacent fractures after kyphoplasty
Chunbiao Deng, Haiqiao Huang, Linlin Chen, Xin Chen, Qian Chen, Yougang Liao, Shuliang Li
BMC Musculoskeletal Disorders.2026;[Epub] CrossRef - Key laboratory changes in severe trauma, a different pattern for each clinical phenotype
Adrián Marcos-Morales, Jesús Abelardo Barea Mendoza, Marcos Valiente Fernández, Carlos García Fuentes, Fernando Calvo Boyero, Cecilia Cueto-Felgueroso, Judith Gutiérrez Gutiérrez, Francisco de Paula Delgado Moya, Carolina Mudarra Reche, Susana Bermejo Azn
Medicina Intensiva.2026; 50(4): 502227. CrossRef - Utility of platelet- to lymphocyte ratio as an inflammatory biomarker in major burns. our experience
Dayamí Zaldívar Castillo MD, Néstor Nemer Pérez MD, Carlos Lora Buelvas MD, Adelmo de J González Méndez MD, Freddy J Cruz Reyes MD, Yaqueline Castellanos MD
Journal of Anesthesia & Critical Care: Open Access.2025; 17(1): 1. CrossRef - The predictors of prognostic nutritional index and its association with in-hospital mortality among critically ill geriatric patients
Khalid Elsayed Elsorady, Ahmed Ahmed Mohamed Abotaha, Mohammed Abdelmoaty Ebrahim Shaheen, Hisham Ahmed Hani Mostafa Abdelaziz, Essam Yehia Ali Aggour, Mohamed Elwan Mohamed Mahmoud
Electronic Journal of General Medicine.2025; 22(4): em656. CrossRef - Prognostic Value of Inflammatory and Metabolic Biomarkers in ICU-Admitted Trauma Patients: A Retrospective Cohort Study
Hasan Celik, Basak Pehlivan, Veli Fahri Pehlivan, Erdogan Duran
Medicina.2025; 61(9): 1530. CrossRef - Utility of systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio as a predictive biomarker in pediatric traumatic brain injury
Muhammad Arifin Parenrengi, Wihasto Suryaningtyas, Ahmad Data Dariansyah, Budi Utomo, Glenn Otto Taryana, Catur Kusumo, Surya Pratama Brilliantika
Surgical Neurology International.2024; 15: 456. CrossRef
- Key laboratory changes in severe trauma, a different pattern for each clinical phenotype
Review Article
- Infection
- Oxygen therapy for sepsis and prevention of complications
- Hayk Minasyan
- Acute Crit Care. 2022;37(2):137-150. Published online March 17, 2022
- DOI: https://doi.org/10.4266/acc.2021.01200
- 24,956 View
- 660 Download
- 14 Web of Science
- 12 Crossref
-
Abstract
PDF
- Patients with sepsis have a wide range of respiratory disorders that can be treated with oxygen therapy. Experimental data in animal sepsis models show that oxygen therapy significantly increases survival, while clinical data on the use of different oxygen therapy protocols are ambiguous. Oxygen therapy, especially hyperbaric oxygenation, in patients with sepsis can aggravate existing oxidative stress and contribute to the development of disseminated intravascular coagulation. The purpose of this article is to compare experimental and clinical data on oxygen therapy in animals and humans, to discuss factors that can influence the results of oxygen therapy for sepsis treatment in humans, and to provide some recommendations for reducing oxidative stress and preventing disseminated intravascular coagulation during oxygen therapy.
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Citations
Citations to this article as recorded by- Completion of the 1-Hour Sepsis Bundle on 90-Day Mortality in Adult Patients With Sepsis
Suraphan Charoentanyarak, Thanapong Chopetgool, Watchara Boonsawat, Kittisak Sawanyawisuth
JACEP Open.2026; 7(1): 100296. CrossRef - Conservative Oxygen Targets in Mechanically Ventilated Patients (OXY-BREATHES): A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nhan Nguyen, Nghi Bao Tran, Nathalia Alves de Barros e Lyra, Yacin Zawam, David Downes, Vinh Quang Tri Ho, Vy Ngoc Dan Nguyen, Ha Duc Thien Le, Jafar Aljazeeri
Critical Care Medicine.2026; 54(5): 1225. CrossRef - OPTIMAL PAO2 IS 130-160 MMHG IN THE FIRST WEEK FOR SEPSIS PATIENTS IN ICU: A RETROSPECTIVE COHORT STUDY BASED ON MIMIC-IV DATABASE
Haoran Chen, Xinyi Tang, Xiaomin Li, Yongpeng Xie
Shock.2025; 63(5): 688. CrossRef - Postoperative pulmonary complications in acute type A aortic dissection
Pengfei Chen, Haochao Li, Chenyu Liu, Mingjian Chen, Diming Zhao, Liang Chen, Xiangyang Qian, Jundong Pu, Zujun Chen, Yuetang Wang, Liqing Wang
BMC Surgery.2025;[Epub] CrossRef - Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis
Louise Nuyttens, Marah Heyerick, Geike Heremans, Elise Moens, Maxime Roes, Céline Van Dender, Liesbet De Bus, Johan Decruyenaere, Jan Dewaele, Jolien Vandewalle, Claude Libert
Cell Reports.2025; 44(8): 116032. CrossRef - Monkeypox in neonates: A narrative review on clinical presentations, vertical transmission, and treatment challenges
Ezza Ikram, Abaidullah Shaukat, Muhammad Shoaib Qureshi, Muneeb Saifullah, M Afaq Aslam, Abbas Muhammad Mehdi
World Journal of Clinical Infectious Diseases.2025;[Epub] CrossRef - Sequential respiratory support in septic patients undergoing continuous renal replacement therapy: A study based on MIMIC-III database
Chunxia Wang, Jianli Zheng, Yilin Zhao, Tiantian Liu, Yucai Zhang
Heliyon.2024; 10(6): e27563. CrossRef - Hyperbaric Oxygenation: Can It Be a Novel Supportive Method in Acute Kidney Injury? Data Obtained from Experimental Studies
Sanjin Kovacevic, Nikola Mitovic, Predrag Brkic, Milan Ivanov, Maja Zivotic, Zoran Miloradovic, Jelena Nesovic Ostojic
Cells.2024; 13(13): 1119. CrossRef - Hyperoxia in Sepsis and Septic Shock: A Comprehensive Review of Clinical Evidence and Therapeutic Implications
Sharayu Paunikar, Vivek Chakole
Cureus.2024;[Epub] CrossRef - Personalized medicine targeting different ARDS phenotypes: The future of pharmacotherapy for ARDS?
Florian Blanchard, Arthur James, Mona Assefi, Natacha Kapandji, Jean-Michel Constantin
Expert Review of Respiratory Medicine.2023; 17(1): 41. CrossRef - Current data regarding homeostasis of tissues oxygenation in pathophysiological and therapeutic circumstances
Constantin Munteanu, Mihaela Antonina Călin, Dragoș Manea, Cristina Popescu, Mădălina Iliescu, Elena Valentina Ionescu, Liliana Stanciu, Mihaela Minea, Carmen Oprea, Doinița Oprea, Mariana Rotariu, Gelu Onose
Balneo and PRM Research Journal.2023; 14(Vol.14, no): 565. CrossRef - Current data regarding homeostasis of tissues oxygenation in pathophysiological and therapeutic circumstances
Constantin Munteanu, Mihaela Antonina Călin, Dragoș Manea, Cristina Popescu, Mădălina Iliescu, Elena Valentina Ionescu, Liliana Stanciu, Mihaela Minea, Carmen Oprea, Doinița Oprea, Mariana Rotariu, Gelu Onose
Balneo and PRM Research Journal.2023; 14(Vol.14, no): 565. CrossRef
- Completion of the 1-Hour Sepsis Bundle on 90-Day Mortality in Adult Patients With Sepsis
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