Acute and Critical Care

1 "double-trigger approach"

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Review Article

Infection
Duration of antibiotic therapy: with or without biomarkers?: Gonçalo Sequeira Guerreiro, João Fustiga, Pedro Póvoa; Acute Crit Care. 2026;41(1):1-11. Published online December 29, 2025; DOI: https://doi.org/10.4266/acc.002525

Abstract PDF: Antimicrobial resistance has emerged as a critical global health challenge. Significant variability in antibiotic prescribing practices underscores the urgent need for high-quality evidence to inform optimal antibiotic prescribing policies. The ideal duration of antimicrobial therapy remains uncertain, and a one-size-fits-all approach is far from ideal. In this review, we examine bacterial growth kinetics and antibiotic pharmacodynamics and explore various strategies for determining the duration of antibiotic therapy: fixed duration, biomarker-guided, clinical course–based, and the more recent double-trigger approach.

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