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Original Article
- Trauma
- Predictive value of initial lactate levels for mortality and morbidity in critically ill pediatric trauma patients: a retrospective study from a Turkish pediatric intensive care unit
- Abdulrahman Özel, Esra Nur İlbeği, Servet Yüce
- Acute Crit Care. 2025;40(1):87-94. Published online February 18, 2025
- DOI: https://doi.org/10.4266/acc.003528
- 6,451 View
- 179 Download
- 4 Web of Science
- 5 Crossref
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Abstract
PDF - Background
This study investigated the relationship between initial lactate levels and both mortality and morbidity in critically ill pediatric trauma patients requiring intensive care.
Methods
This retrospective study at tertiary center’s pediatric intensive care unit from January 2020 to June 2024 aimed to characterize trauma patients and assess admission lactate levels' prognostic value.
Results
A total of 190 critically ill pediatric trauma patients were included in the study. The mortality rate was 7.9%, with most deaths occurring within the first 48 hours of admission. Initial lactate levels ≥6.9 mmol/L demonstrated moderate predictive power (area under the curve [AUC], 0.878) for mortality. Pediatric Risk of Mortality III (PRISM III) score showed good predictive ability (AUC, 0.922), while Pediatric Trauma Scores exhibited variable predictive performance (AUC, 0.863). Higher initial lactate levels were significantly associated with severe brain injury, the need for intubation, and an increased incidence of thoracic or abdominal injuries.
Conclusions
Initial lactate levels and PRISM III score are effective predictors of mortality in critically ill pediatric trauma patients. Lactate levels ≥5 mmol/L upon admission should prompt close monitoring and consideration of aggressive management strategies. -
Citations
Citations to this article as recorded by
- Beyond survival: Early markers of poor outcome in pediatric trauma
Kubra Boydag Guvenc, Ebru Guney Sahin, Idris Abdullah Yılmaz, Refik Ozturk, Ceyhan Sahin, Fatih Varol, Cansu Durak
The American Journal of Emergency Medicine.2026; 101: 103. CrossRef - PIM2, lactate, and trauma score to predict mortality in critically ill pediatric trauma patients
Luciana G. Barcellos, Fernanda M. Rubin, Ana Paula P. da Silva, Júlia L. Vieira, Luciane G. da Cunha, Lucinara V. Enéas Machado, Geniara da S. Conrado, Cristian T. Tonial
Jornal de Pediatria.2026; 102(2): 101509. CrossRef - Prognostic value of lactate-to-albumin ratio and inflammatory indices in pediatric traumatic brain injury: A comparative study with PRISM III
Özlem Bostan Gayret, Abdulrahman Özel, Servet Yüce, Harun Çatak, Selen Mandel Işikli, Meltem Erol
Medicine.2026; 105(8): e47689. CrossRef - Incidence, severity and outcomes of hypoxemia in paediatric emergencies seen at a tertiary hospital in Southern Nigeria
Moses T. Abiodun, Gabriel Oziegbe, Imuwahen A. Mbarie, Wilson O. Osarogiagbon, Collins E. Etin-Osa, Rosena O. Oluwafemi, Godwin E. Okungbowa, Ovonomo Ewhe, Rahmon Olusola, Benjamin Nandom, Adesuwa Kpongo-Ogieva, Jane Aghama, Cyril Oputa
International Journal of Contemporary Pediatrics.2025; 12(8): 1289. CrossRef - Prognostic value of the lactate dehydrogenase-to-albumin ratio for predicting mortality in critically ill pediatric patients: a retrospective cohort study
Ming Liu, Yunpeng Gou, Ping Yang
Frontiers in Pediatrics.2025;[Epub] CrossRef
- Beyond survival: Early markers of poor outcome in pediatric trauma
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