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Original Article
- Pulmonary
- Comparison of preoxygenation with a high-flow nasal cannula and a simple face mask before intubation in Korean patients with head and neck cancer
- Jun-Young Jo, Jungpil Yoon, Heeyoon Jang, Wook-Jong Kim, Seungwoo Ku, Seong-Soo Choi
- Acute Crit Care. 2024;39(1):61-69. Published online January 26, 2024
- DOI: https://doi.org/10.4266/acc.2022.01543
- 8,909 View
- 297 Download
- 5 Web of Science
- 5 Crossref
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Abstract
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Supplementary Material - Background
Although preoxygenation is an essential procedure for safe endotracheal intubation, in some cases securing sufficient time for tracheal intubation may not be possible. Patients with head and neck cancer might have a difficult airway and need a longer time for endotracheal intubation. We hypothesized that the extended apneic period with preoxygenation via a high-flow nasal cannula (HFNC) is beneficial to patients who undergo head and neck surgery compared with preoxygenation with a simple mask.
Methods
The study was conducted as a single-center, single-blinded, prospective, randomized controlled trial. Patients were divided into groups based on one of the two preoxygenation methods: HFNC group or simple facemask (mask group). Preoxygenation was performed for 5 minutes with each method, and endotracheal intubation for all patients was performed using a video laryngoscope. Oxygen partial pressures of the arterial blood were compared at the predefined time points.
Results
For the primary outcome, the mean arterial oxygen partial pressure (PaO2 ) immediately after intubation was 454.2 mm Hg (95% confidence interval [CI], 416.9–491.5 mm Hg) in the HFNC group and 370.7 mm Hg (95% CI, 333.7–407.4 mm Hg) in the mask group (P=0.002). The peak PaO2 at 5 minutes after preoxygenation was not statistically different between the groups (P=0.355).
Conclusions
Preoxygenation with a HFNC extending to the apneic period before endotracheal intubation may be beneficial in patients with head and neck cancer. -
Citations
Citations to this article as recorded by
- High-flow nasal oxygen versus face-mask ventilation for rapid sequence induction in non-elective surgical patients: a randomized controlled trial
Nguyen Duc Lam, Le Dinh Thanh Son, Tran Minh Phat, Nguyen Dang Thu, Nguyen Thuy Nga, Vuong Trung Son, Bui Minh Hong
BMC Anesthesiology.2026;[Epub] CrossRef - High-Flow Nasal Cannula Oxygen Therapy in Perioperative Respiratory Care: Application and Prospects
Jing Chen, Xinyue Hu, Dong Han, Yuwei Liu, Danqi Chen, Shuangyun Chen, Yuwei Chen, Jing Wu
Journal of Multidisciplinary Healthcare.2026; Volume 19: 1. CrossRef - Guidelines 2024: Emergency intubation of an adult outside the operating room and intensive care unit
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Anaesthesia Critical Care & Pain Medicine.2026; 45(3): 101744. CrossRef - Application Progress of Nasal High-Flow Oxygen Therapy in Clinical Anesthesia
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Advances in Clinical Medicine.2026; 16(04): 76. CrossRef - Place de l’oxygénation haut débit dans la gestion des voies aériennes au bloc opératoire
Antoine Duwat, Romain Deransy
Anesthésie & Réanimation.2025; 11(5-6): 393. CrossRef
- High-flow nasal oxygen versus face-mask ventilation for rapid sequence induction in non-elective surgical patients: a randomized controlled trial
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