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6 "Se Kyu Kim"
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Original Articles
Infection
Implications of Plasma Renin Activity and Plasma Aldosterone Concentration in Critically Ill Patients with Septic Shock
Kyung Soo Chung, Joo Han Song, Won Jai Jung, Young Sam Kim, Se Kyu Kim, Joon Chang, Moo Suk Park
Korean J Crit Care Med. 2017;32(2):142-153.   Published online May 31, 2017
DOI: https://doi.org/10.4266/kjccm.2017.00094
  • 8,804 View
  • 217 Download
  • 15 Web of Science
  • 16 Crossref
AbstractAbstract PDFSupplementary Material
Background
The renin-angiotensin-aldosterone system is closely associated with volume status and vascular tone in septic shock. The present study aimed to assess whether plasma renin activity (PRA) and plasma aldosterone concentration (PAC) measurements compared with conventional severity indicators are associated with mortality in patients with septic shock.
Methods
We evaluated 105 patients who were admitted for septic shock. Plasma levels of the biomarkers PRA and PAC, the PAC/PRA ratio, C-reactive protein (CRP) level, and cortisol level on days 1, 3, and 7 were serially measured. During the intensive care unit stay, relevant clinical information and laboratory results were recorded.
Results
Patients were divided into two groups according to 28-day mortality: survivors (n = 59) and non-survivors (n = 46). The survivor group showed lower PRA, PAC, Acute Physiologic and Chronic Health Evaluation (APACHE) II score, and Sequential Organ Failure Assessment (SOFA) score than did the non-survivor group (all P < 0.05). The SOFA score was positively correlated with PRA (r = 0.373, P < 0.001) and PAC (r = 0.316, P = 0.001). According to receiver operating characteristic analysis, the areas under the curve of PRA and PAC to predict 28-day mortality were 0.69 (95% confidence interval [CI], 0.58 to 0.79; P = 0.001) and 0.67 (95% CI, 0.56 to 0.77; P = 0.003), respectively, similar to the APACHE II scores and SOFA scores. In particular, the group with PRA value ≥3.5 ng ml-1 h-1 on day 1 showed significantly greater mortality than did the group with PRA value <3.5 ng ml-1 h-1 (log-rank test, P < 0.001). According to multivariate analysis, SOFA score (hazard ratio, 1.11; 95% CI, 1.01 to 1.22), PRA value ≥3.5 ng ml-1 h-1 (hazard ratio, 3.25; 95% CI, 1.60 to 6.60), previous history of cancer (hazard ratio, 3.44; 95% CI, 1.72 to 6.90), and coronary arterial occlusive disease (hazard ratio, 2.99; 95% CI, 1.26 to 7.08) were predictors of 28-day mortality.
Conclusions
Elevated PRA is a useful biomarker to stratify the risk of critically ill patients with septic shock and is a prognostic predictor of 28-day mortality.

Citations

Citations to this article as recorded by  
  • Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial*
    Laurence W. Busse, Christopher L. Schaich, Mark C. Chappell, Michael T. McCurdy, Erin M. Staples, Caitlin C. Ten Lohuis, Jeremiah S. Hinson, Jonathan E. Sevransky, Richard E. Rothman, David W. Wright, Greg S. Martin, Ashish K. Khanna
    Critical Care Medicine.2024; 52(3): 441.     CrossRef
  • Renin as a Prognostic Marker in Intensive Care and Perioperative Settings: A Scoping Review
    Yuki Kotani, Alessandro Belletti, Giacomo Maiucci, Martina Lodovici, Stefano Fresilli, Giovanni Landoni, Rinaldo Bellomo, Alexander Zarbock
    Anesthesia & Analgesia.2024; 138(5): 929.     CrossRef
  • Renin as a Prognostic and Predictive Biomarker in Sepsis: More Questions Than Answers?*
    Emily J. See, James A. Russell, Rinaldo Bellomo, Patrick R. Lawler
    Critical Care Medicine.2024; 52(3): 509.     CrossRef
  • Dysfunction of the renin-angiotensin-aldosterone system in human septic shock
    Christopher L. Schaich, Daniel E. Leisman, Marcia B. Goldberg, Micheal R. Filbin, Ashish K. Khanna, Mark C. Chappell
    Peptides.2024; 176: 171201.     CrossRef
  • Renin in critically ill patients
    Yuki Kotani, Mark Chappell, Giovanni Landoni, Alexander Zarbock, Rinaldo Bellomo, Ashish K. Khanna
    Annals of Intensive Care.2024;[Epub]     CrossRef
  • Blood urea nitrogen - independent marker of mortality in sepsis
    Martin Harazim, Kaiquan Tan, Marek Nalos, Martin Matejovic
    Biomedical Papers.2023; 167(1): 24.     CrossRef
  • Critically ill children with septic shock: time to rediscover renin?
    Isabella Guzzo, Fabio Paglialonga
    Pediatric Nephrology.2023; 38(9): 2907.     CrossRef
  • The role of proadrenomedullin, interleukin 6 and CD64 in the diagnosis and prognosis of septic shock
    Yasemin Bozkurt Turan
    BMC Anesthesiology.2023;[Epub]     CrossRef
  • Renin Kinetics Are Superior to Lactate Kinetics for Predicting In-Hospital Mortality in Hypotensive Critically Ill Patients*
    Maniraj Jeyaraju, Michael T. McCurdy, Andrea R. Levine, Prasad Devarajan, Michael A. Mazzeffi, Kristin E. Mullins, Michaella Reif, David N. Yim, Christopher Parrino, Allison S. Lankford, Jonathan H. Chow
    Critical Care Medicine.2022; 50(1): 50.     CrossRef
  • Mechanisms of Post-critical Illness Cardiovascular Disease
    Andrew Owen, Jaimin M. Patel, Dhruv Parekh, Mansoor N. Bangash
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Renin as a Marker of Tissue Perfusion, Septic Shock and Mortality in Septic Patients: A Prospective Observational Study
    Patrycja Leśnik, Lidia Łysenko, Małgorzata Krzystek-Korpacka, Ewa Woźnica-Niesobska, Magdalena Mierzchała-Pasierb, Jarosław Janc
    International Journal of Molecular Sciences.2022; 23(16): 9133.     CrossRef
  • Angiotensin II and Vasopressin for Vasodilatory Shock: A Critical Appraisal of Catecholamine-Sparing Strategies
    Mojdeh S. Heavner, Michael T. McCurdy, Michael A. Mazzeffi, Samuel M. Galvagno, Kenichi A. Tanaka, Jonathan H. Chow
    Journal of Intensive Care Medicine.2021; 36(6): 635.     CrossRef
  • Treatment of Renin-Angiotensin-Aldosterone System Dysfunction With Angiotensin II in High-Renin Septic Shock
    Jonathan H. Chow, Marianne Wallis, Allison S. Lankford, Zackary Chancer, Rolf N. Barth, Joseph R. Scalea, John C. LaMattina, Michael A. Mazzeffi, Michael T. McCurdy
    Seminars in Cardiothoracic and Vascular Anesthesia.2021; 25(1): 67.     CrossRef
  • Good clinical practice for the use of vasopressor and inotropic drugs in critically ill patients: state-of-the-art and expert consensus
    Andrea CARSETTI, Elena BIGNAMI, Andrea CORTEGIANI, Katia DONADELLO, Abele DONATI, Giuseppe FOTI, Giacomo GRASSELLI, Stefano ROMAGNOLI, Massimo ANTONELLI, Elvio DE BLASIO, Francesco FORFORI, Fabio GUARRACINO, Sabino SCOLLETTA, Luigi TRITAPEPE, Luigia SCUDE
    Minerva Anestesiologica.2021;[Epub]     CrossRef
  • Use of Angiotensin II in Severe Vasoplegia After Left Pneumonectomy Requiring Cardiopulmonary Bypass: A Renin Response Analysis
    Brian Trethowan, Christopher J. Michaud, Sarah Fifer
    Critical Care Medicine.2020; 48(10): e912.     CrossRef
  • Renin as a Marker of Tissue-Perfusion and Prognosis in Critically Ill Patients*
    Patrick J. Gleeson, Ilaria Alice Crippa, Wasineenart Mongkolpun, Federica Zama Cavicchi, Tess Van Meerhaeghe, Serge Brimioulle, Fabio Silvio Taccone, Jean-Louis Vincent, Jacques Creteur
    Critical Care Medicine.2019; 47(2): 152.     CrossRef
Rapid response system
A Pilot Study of the Effectiveness of Medical Emergency System Implementation at a Single Center in Korea
Su Hwan Lee, Ah Young Leem, Youngok Nho, Young Ah Kim, Kyung Duck Kim, Young Sam Kim, Se Kyu Kim, Kyung Soo Chung
Korean J Crit Care Med. 2017;32(2):133-141.   Published online May 16, 2017
DOI: https://doi.org/10.4266/kjccm.2016.01011
  • 6,149 View
  • 111 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Background
An automatic alarm system was developed was developed for unexpected vital sign instability in admitted patients to reduce staffing needs and costs related to rapid response teams. This was a pilot study of the automatic alarm system, the medical emergency system (MES), and the aim of this study was to determine the effectiveness of the MES before expanding this system to all departments.
Methods
This retrospective, observational study compared the performance of patients admitted to the pulmonary department at a single center using patient data from three 3-month periods (before implementation of the MES: December 2013-February 2014; after implementation of the MES: December 2014-February 2015 and December 2015-February 2016).
Results
A total of 571 patients were admitted to the pulmonary department during the three observation periods. During this pilot study, the MES automatically issued 568 alarms for 415 admitted patients. There was no significant difference in the rate of cardiopulmonary resuscitation (CPR) before and after application of the MES. The mortality rate also did not change. However, it appeared that CPR was prevented in four patients admitted from the general ward to the intensive care unit (ICU) during MES implementation. The median length of hospital stay and median length of ICU stay were not significantly different before and after MES implementation.
Conclusions
Although we did not find a significant improvement in outcomes upon MES implementation, the CPR rate and mortality rate did not increase despite increased comorbidities. This was a small pilot study, and, based on these results, we believe that the MES may have significant effects in longer-term and larger-scale studies.

Citations

Citations to this article as recorded by  
  • Society of Critical Care Medicine Guidelines on Recognizing and Responding to Clinical Deterioration Outside the ICU: 2023
    Kimia Honarmand, Randy S. Wax, Daleen Penoyer, Geoffery Lighthall, Valerie Danesh, Bram Rochwerg, Michael L. Cheatham, Daniel P. Davis, Michael DeVita, James Downar, Dana Edelson, Alison Fox-Robichaud, Shigeki Fujitani, Raeann M. Fuller, Helen Haskell, Ma
    Critical Care Medicine.2024; 52(2): 314.     CrossRef
  • Rapid response systems in Korea
    Bo Young Lee, Sang-Bum Hong
    Acute and Critical Care.2019; 34(2): 108.     CrossRef
Basic science and research
Changes in Insulin-like Growth Factor-1 Level in Patients with Sepsis and Septic Shock
Sang Hoon Lee, Byung Hoon Park, Joo Han Song, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Young Sam Kim, Se Kyu Kim, Joon Chang, Moo Suk Park
Korean J Crit Care Med. 2016;31(4):324-333.   Published online November 30, 2016
DOI: https://doi.org/10.4266/kjccm.2016.00024
  • 7,403 View
  • 117 Download
AbstractAbstract PDF
Background
Despite many ongoing, prospective studies on the topic, sepsis still remains one of the main causes of death in hospital. The hormone insulin-like growth factor 1 (IGF-1) has a similar molecular structure to that of insulin. IGF-1 exerts anabolic effects and plays important roles in both normal physiology and pathologic processes. Previous studies have observed low serum IGF-1 level in patients with critical illnesses. Here, we evaluated changes in IGF-1 level based on survival of septic patients.
Methods
We evaluated 140 patients with sepsis and septic shock (21 with sepsis and 119 with septic shock) admitted to the intensive care unit of a university-affiliated hospital in Korea. Serum IGF-1 level was measured on days 0, 1, 3, and 7. Patients with liver disease were excluded from this study. All data were analyzed using SPSS version 20 (SPSS Inc., Chicago, IL, USA).
Results
Patients with septic shock had significantly lower serum IGF-1 level on days 1 and 3 than patients without septic shock (p = 0.002 and p = 0.007, respectively). Generally, there was a negative relationship between IGF-1 and serum cortisol levels; however, this relationship was only significant on day 3 (p = 0.029). Furthermore, renin showed significantly negative correlation with IGF-1 on day 3 (p = 0.038). IGF-1 level did not show significant difference between survivors and non-survivors.
Conclusions
Our results showed that IGF-1 was associated with septic shock, and that the IGF-1 axis is severely disrupted in septic patients. Additionally, serum cortisol and renin levels were associated with IGF-1 level.
Case Reports
Hematology/Pulmonary
Hemophagocytic Lymphohistiocytosis after Lung Transplantation
Ah Young Leem, Sung Woo Moon, Song Yee Kim, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Hyo Chae Paik, June Won Cheong, Kyung Soo Chung
Korean J Crit Care Med. 2015;30(1):38-41.   Published online February 28, 2015
DOI: https://doi.org/10.4266/kjccm.2015.30.1.38
  • 57,894 View
  • 80 Download
AbstractAbstract PDF
Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal complication after solid organ transplantation. Acquired forms of HLH are described in association with severe sepsis, autoimmune disorders, malignancy, immune-compromised states, infections, and solid organ transplantation. We experienced a case of hemophagocytic lymphohistiocytosis after bilateral lung transplantation. Leukopenia, thrombocytopenia, and hyperbilirubinemia were noted and became aggravated 50 days after transplantation. Diagnosis of HLH was based on clinical and laboratory findings of splenomegaly, cytopenia, elevated ferritin, elevated interleukin-2 receptor, and hemophagocytosis in bone marrow. Other features such as elevated bilirubin, lactate dehydrogenase, and D-dimer which can be present in HLH were also noted. The patient was immediately treated with etoposide and dexamethasone. Despite aggressive therapy, the patient deteriorated and died. Awareness of the diagnostic criteria of HLH after lung transplantation is important for clinicians.
Hematology/Pulmonary
Delayed Hemolytic Uremic Syndrome Presenting as Diffuse Alveolar Hemorrhage
Ji Young Hong, Ji Ye Jung, Young Ae Kang, Yoon Sung Bae, Young Sam Kim, Se Kyu Kim, Joon Chang, Moo Suk Park
Korean J Crit Care Med. 2014;29(1):43-47.   Published online February 28, 2014
DOI: https://doi.org/10.4266/kjccm.2014.29.1.43
  • 7,027 View
  • 114 Download
  • 5 Crossref
AbstractAbstract PDF
Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical intravascular hemolytic anemia with schistocytosis, thrombocytopenia and acute renal failure. Pulmonary involvement in HUS is known to be rare. We present the case of a 25-year-old male with diffuse alveolar hemorrhage and myocarditis followed by atypical hemolytic uremic syndrome. In this case, successful treatments included steroid pulse therapy for the fatal alveolar hemorrhage and plasma exchange for the hemolytic uremic syndrome.

Citations

Citations to this article as recorded by  
  • Development and pilot implementation of Iranian Hemolytic Uremic Syndrome Registry
    Mina Lazem, Nakysa Hooman, Abbas Sheikhtaheri
    Orphanet Journal of Rare Diseases.2022;[Epub]     CrossRef
  • Lessons learned from hemolytic uremic syndrome registries: recommendations for implementation
    Mina Lazem, Abbas Sheikhtaheri, Nakysa Hooman
    Orphanet Journal of Rare Diseases.2021;[Epub]     CrossRef
  • The Prevalence and Incidence of Atypical Hemolytic Uremic Syndrome in Iran: A Systematic Review and Meta-Analysis Protocol Study
    Nakysa Hooman, Mahnaz Sadeghian, Fariba Jahangiri, Soudabeh Hosseini
    Journal of Comprehensive Pediatrics.2017;[Epub]     CrossRef
  • Subcapsular liver hematoma as a complication of an atypical hemolytic uremic syndrome
    Emanuel Ferreira, Nuno Oliveira, Maria Marques, Helena Pinto, Ana Santos, Armando Carreira, Mário Campos
    Nefrología (English Edition).2015; 35(3): 337.     CrossRef
  • Subcapsular liver hematoma as a complication of an atypical hemolytic uremic syndrome
    Emanuel Ferreira, Nuno Oliveira, Maria Marques, Helena Pinto, Ana Santos, Armando Carreira, Mário Campos
    Nefrología.2015; 35(3): 337.     CrossRef
A Case of Prolonged Extracorporeal Membrane Oxygenation Support for Severe Acute Respiratory Distress Syndrome: A Case Report
Byung Hoon Park, Joon Chang, Se Kyu Kim, Young Ae Kang, Ji Young Son, Kyung Jong Lee, Yoe Wun Yoon, Ji Ae Jung, Sak Lee, Moo Suk Park
Korean J Crit Care Med. 2010;25(1):37-42.
DOI: https://doi.org/10.4266/kjccm.2010.25.1.37
  • 3,201 View
  • 26 Download
  • 3 Crossref
AbstractAbstract PDF
When all the conventional treatments have failed for patients with acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO) can offer these patients a chance to survive. We report here on a case of successful treatment with prolonged ECMO support for a patient with severe ARDS. A 41-year-old female patient with acute A-viral hepatitis developed pneumonia and progressive ARDS. After tracheostomy, her clinical condition deteriorated despite proper antibiotic administration and other conventional treatments, including the recruitment maneuver and steroid use. Venoarterial ECMO was given for the management of refractory hypoxemia that developed 14 days after the initiation of mechanical ventilation. The duration of ECMO support was 4 weeks, and she was successfully weaned off ECMO and mechanical ventilation.

Citations

Citations to this article as recorded by  
  • Early Extracorporeal Membrane Oxygenation for Massive Aspiration during Anesthesia Induction
    Namo Kim, Kwan Hyung Kim, Jeong Min Kim, Su Youn Choi, Sungwon Na
    The Korean Journal of Critical Care Medicine.2015; 30(2): 109.     CrossRef
  • Massive Diffuse Alveolar Hemorrhage Caused by the Aspiration of Gastric Contents during Induction of Anesthesia in Patients with Adhesive Ileus - A Case Report -
    Ji Seon Jeong, Jong Hun Jun, Hyo Jin Song, Hee Koo Yoo
    Korean Journal of Critical Care Medicine.2012; 27(2): 115.     CrossRef
  • Extracorporeal Membrane Oxygenation as a Bridge to Definitive Airway Security in 3 Severe Acute Extrinsic Airway Compression Patients - A Case Report -
    Jiwon Lyu, Jin Won Huh, Chae Man Lim, Youn Suck Koh, Sang Bum Hong
    The Korean Journal of Critical Care Medicine.2011; 26(1): 29.     CrossRef

ACC : Acute and Critical Care