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Original Article
- Infection
- Clinical features and outcomes of critically ill patients with Elizabethkingia meningoseptica: an emerging pathogen
- Abdullah Umair, Nosheen Nasir
- Acute Crit Care. 2021;36(3):256-261. Published online July 26, 2021
- DOI: https://doi.org/10.4266/acc.2020.01158
- 8,424 View
- 238 Download
- 10 Web of Science
- 11 Crossref
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Abstract
PDF - Background
Elizabethkingia meningoseptica, formerly known as Chryseobacterium meningosepticum, is a non-motile, non-fastidious, catalase and oxidase-positive, aerobic, glucosenon- fermentative, Gram-negative bacillus that was first defined by Elizabeth O. King in 1959. It has emerged as an opportunistic pathogen that has infected patients in extreme age groups and immunocompromised individuals, especially in intensive care settings. There has been an increased interest in this pathogen due to its increasing occurrence around the world, ubiquitous nature, and inherent capacity for antimicrobial resistance.
Methods
We describe an observational study at a tertiary care center in Karachi, Pakistan, based on patients admitted between January 2013 and December 2018, with E. meningoseptica infections. All patients were confirmed to have a positive clinical culture specimen for E. meningoseptica along with symptoms and signs consistent with infection. Data were collected on a structured proforma from the Hospital Information Management Systems.
Results
Sixteen patients with E. meningoseptica that met the criteria for infection were identified, 13 of whom required admission. Eight patients had bacteremia in addition to confirmed E. meningoseptica infection. Two of the isolates were multi-drug resistant and only sensitive to minocycline. Nine out of 13 patients that were admitted required intubation and mechanical ventilation. The median length of hospital stay was 13 days, and five out of the 13 patients died during the hospital stay.
Conclusions
This is the largest case series to date reporting E. meningoseptica infections and highlights the importance of this organism as an emerging nosocomial pathogen. -
Citations
Citations to this article as recorded by
- Clinical and microbiological features of positive blood culture episodes caused by non-fermenting gram-negative bacilli other than Pseudomonas and Acinetobacter species (2020–2023)
Roberto Casale, Matteo Boattini, Sara Comini, Paulo Bastos, Silvia Corcione, Francesco Giuseppe De Rosa, Gabriele Bianco, Cristina Costa
Infection.2025; 53(1): 183. CrossRef - Elizabethkingia meningoseptica in Dubai, United Arab Emirates: A 7-year multicenter study
Hawra Ali Hussain Alsayed, Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Rabih Halwani
American Journal of Infection Control.2025; 53(3): 326. CrossRef - “Unmasking the Uncommon”: A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates
Prajnha U.P., Anisha Maria Fernandes, Suchitra Shenoy M., Sinchana Bhat
F1000Research.2025; 13: 1367. CrossRef - Evaluation of Conventional Polymerase Chain Reaction for Accurate Species Identification of Elizabethkingia Compared to Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Sailaxmi Mahapatra, Ashoka Mahapatra, Sushree Sarathi, Bijayini Behera, Sarita Mohapatra
Cureus.2025;[Epub] CrossRef - Elizabethkingia meningoseptica Outbreak in NICU: An Observational Study on a Debilitating Neuroinfection in Neonates
Manish Swami, Praneetha Mude, Shrutiprajna Kar, Sushree Sarathi, Ashoka Mohapatra, Usha Devi, Pankaj K. Mohanty, Tapas K. Som, Behera Bijayini, Tanushree Sahoo
Pediatric Infectious Disease Journal.2024; 43(1): 63. CrossRef - Clinical Characteristics and Risk Factors for Infection and Death in Critically Ill Patients with Pulmonary Infection with Elizabethkingia Spp.
Mengwen Feng, Min Huang, Yuanyuan Fan, Genyan Liu, Suming Zhou, Jing Zhou
Infection and Drug Resistance.2024; Volume 17: 2673. CrossRef - Mortality Risk and Antibiotic Therapy for Patients with Infections Caused by Elizabethkingia Species—A Meta-Analysis
Chienhsiu Huang, Sufang Kuo, Lichen Lin
Medicina.2024; 60(9): 1529. CrossRef - “Unmasking the Uncommon”: A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates
Prajnha U.P., Anisha Maria Fernandes, Suchitra Shenoy M., Sinchana Bhat
F1000Research.2024; 13: 1367. CrossRef - Multi-Drug-Resistant Elizabethkingia meningoseptica: A Rare Cause of Late-Onset Sepsis in a Preterm Neonate
Abdul Wasey Hashmi, Muhammad Ahmad, Muhammad Muneeb Israr, Ibtesam e Fajar, Farid Adnan
Cureus.2023;[Epub] CrossRef - Current viewpoint on the epidemiology of nonfermenting Gram-negative bacterial strains
Despoina Koulenti, Kalwaje Eswhara Vandana, Jordi Rello
Current Opinion in Infectious Diseases.2023; 36(6): 545. CrossRef - Epidemiological, clinical, and laboratory features of patients infected with Elizabethkingia meningoseptica at a tertiary hospital in Hefei City, China
Yajuan Li, Tingting Liu, Cuixiao Shi, Bo Wang, Tingting Li, Ying Huang, Yuanhong Xu, Ling Tang
Frontiers in Public Health.2022;[Epub] CrossRef
- Clinical and microbiological features of positive blood culture episodes caused by non-fermenting gram-negative bacilli other than Pseudomonas and Acinetobacter species (2020–2023)
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