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- Successful treatment of propofol-related infusion syndrome in critically ill patient receiving low-dose propofol infusion: a case report
- Nahyeon Park, Tae Sun Ha
- Acute Crit Care. 2023;38(1):144-148. Published online November 26, 2021
- DOI: https://doi.org/10.4266/acc.2021.00829
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- 5 Web of Science
- 7 Crossref
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Abstract
PDF - Propofol is widely used to sedate agitated patients in intensive care units. However, it can cause a rare but fatal complication, propofol-related infusion syndrome (PRIS). The pathophysiology of PRIS is not clear, and there is no definitive diagnosis and treatment. We report a successfully treated case of PRIS in a critically ill patient receiving low-dose propofol infusion. A 59-year-old male patient complaining of sudden chest pain repeatedly collapsed in an ambulance and the emergency room, and veno-arterial extracorporeal membrane oxygenation was delivered. He was diagnosed with a total occluded left anterior descending coronary artery in coronary angiography. On day 20, he showed arrhythmia, increased creatinine kinase (CK), and increased CK-MB and troponin I, accompanied by unstable hemodynamic status despite high-dose vasopressors. He was administered propofol for 20 days at an average dose of 1.3 mg/kg/hr owing to issues with agitation and ventilator synchrony. We strongly suspected PRIS and immediately discontinued propofol infusion, and he was successfully treated with aggressive supportive care. PRIS can occur in patients administered propofol for a prolonged period at low doses. Thus, clinicians should use propofol with caution for PRIS and change to alternative sedatives for long-term sedation.
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Citations
Citations to this article as recorded by
- Beyond the usual: A focus on infrequent complications of CRRT
Gonzalo Ramírez-Guerrero, Cristian Pedreros-Rosales, David Ballesteros, Mitchell Rosner, Claudio Ronco
Journal of Critical Care.2026; 91: 155270. CrossRef - Propofol Infusion Syndrome Induced by Short-Term Low-Dose Infusion in a Patient during ECMO Support: A Case Report and Literature Review
思卿 王
Advances in Clinical Medicine.2026; 16(04): 3968. CrossRef - Pharmacovigilance and toxicological studies on safety signals associated with the combined use of propofol and midazolam
Wei Wei, Lu Wang, Liang Chen, Xiaomei Ying, Shuangshuang Xu
BMC Anesthesiology.2026;[Epub] CrossRef - Propofol-related infusion syndrome happened in a non-critically ill perioperative young patient: A case report
Haibo Zhang, Yezu Liu, Minlong Liu, Bing Li, Haima Li
SAGE Open Medical Case Reports.2025;[Epub] CrossRef - Electroencephalogram prediction of propofol effects on neuromodulation in disorders of consciousness
Xuewei Qin, Xuanling Chen, Xin Zhao, Lan Yao, Hongchuan Niu, Kai Li, Yuanli Zhao, Zhenhu Liang, Zhilei Lan, Yuqian Wang, Xiangyang Guo, Jiapeng Huang, Xiaoli Li
Frontiers in Neurology.2025;[Epub] CrossRef - Therapeutic Aspects of Lipofilling, Abdominoplasty in Combination with Body Liposuction and Bariatric Surgery
I. Murkamilov, K. Aitbaev, D. Ymankulov, Sh. Hakimov, Z. Raimzhanov, Z. Yusupova, T. Yusupova, F. Yusupov
Bulletin of Science and Practice.2024; 10(7): 188. CrossRef - Propofol in ICU Settings: Understanding and Managing Anti-Arrhythmic, Pro-Arrhythmic Effects, and Propofol Infusion Syndrome
Jananthan Paramsothy, Sai Dheeraj Gutlapalli, Vijay Durga Pradeep Ganipineni, Isabelle Mulango, Ikpechukwu J Okorie, Divine Besong Arrey Agbor, Crystal Delp, Hanim Apple, Borislav Kheyson, Jay Nfonoyim, Nidal Isber, Mallikarjuna Yalamanchili
Cureus.2023;[Epub] CrossRef
- Beyond the usual: A focus on infrequent complications of CRRT
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