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Original Article
- Epidemiology
- Post-traumatic stress disorder, anxiety, and depression in North African intensive care unit survivors: a prospective observational study
- Imen Ben Saida, Marwa Zghidi, Safa Fathallah, Mohamed Boussarsar
- Acute Crit Care. 2025;40(3):402-412. Published online August 29, 2025
- DOI: https://doi.org/10.4266/acc.000150
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- 126 Download
- 1 Web of Science
- 1 Crossref
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Abstract
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Supplementary Material - Background
Survivors of critical illness often face significant physical and psychological challenges, including post-traumatic stress disorder (PTSD), anxiety, and depression, which can severely impact their quality of life. This study aimed to evaluate the prevalence and associated factors of PTSD, anxiety, and depression among intensive care unit (ICU) survivors 3 months after discharge, and investigate the prevalence and determinants of post-intensive care syndrome–related neuropsychiatric disorders (PICS-ND).
Methods
This is a prospective observational analytical study carried out in a medical ICU. Three months after discharge from the ICU, survivors were contacted by telephone to complete the Impact Event Scale-Revised and Hospital Anxiety and Depression Scale questionnaires. Univariate and multivariate analyses were performed to identify variables that were independently and significantly associated with outcomes.
Results
A total of 114 survivors was enrolled. At 3 months, PTSD, anxiety, and depression were prevalent in 21.9%, 21.0%, and 9.6% of patients, respectively. Associated factors were younger age, female, physical restraint, and critical illness polyneuropathy and myopathy (CIPNM) for PTSD; unmarried, low Charlson index, and physical restraint for anxiety; and younger age and CIPNM for depression. PICS-ND, a composite measure of neuropsychiatric morbidity, was present in 28.9% of patients, with younger age, female, and physical restraint identified as associated factors.
Conclusions
PTSD, anxiety, depression, and PICS-ND were common among ICU survivors at 3 months. Various factors, including younger age, female, unmarried, lower Charlson index, physical restraint, and CIPNM, were associated with these psychological outcomes. -
Citations
Citations to this article as recorded by
- Effect of high-dose baclofen on post-traumatic stress disorder symptoms five years after hospitalization among critically ill patients with unhealthy alcohol use
Marwan Bouras, Karim Asehnoune, Yann Robert-Valli, Pierre-Joachim Mahe, Jean Reignier, Adel Maamar, Jean-Claude Lacherade, Maud Jonas, Boris Jung, Martine Ferrandiere, Samir Jaber, Laurent Flet, Mikael Moriconi, Sigismond Lasocki, Roland Smonig, Christoph
Scientific Reports.2026;[Epub] CrossRef
- Effect of high-dose baclofen on post-traumatic stress disorder symptoms five years after hospitalization among critically ill patients with unhealthy alcohol use
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