Skip Navigation
Skip to contents

ACC : Acute and Critical Care

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
6 "Heung Bum Lee"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Articles
Pulmonary
Association between mechanical power and intensive care unit mortality in Korean patients under pressure-controlled ventilation
Jae Kyeom Sim, Sang-Min Lee, Hyung Koo Kang, Kyung Chan Kim, Young Sam Kim, Yun Seong Kim, Won-Yeon Lee, Sunghoon Park, So Young Park, Ju-Hee Park, Yun Su Sim, Kwangha Lee, Yeon Joo Lee, Jin Hwa Lee, Heung Bum Lee, Chae-Man Lim, Won-Il Choi, Ji Young Hong, Won Jun Song, Gee Young Suh
Acute Crit Care. 2024;39(1):91-99.   Published online January 26, 2024
DOI: https://doi.org/10.4266/acc.2023.00871
  • 616 View
  • 41 Download
AbstractAbstract PDFSupplementary Material
Background
Mechanical power (MP) has been reported to be associated with clinical outcomes. Because the original MP equation is derived from paralyzed patients under volume-controlled ventilation, its application in practice could be limited in patients receiving pressure-controlled ventilation (PCV). Recently, a simplified equation for patients under PCV was developed. We investigated the association between MP and intensive care unit (ICU) mortality. Methods: We conducted a retrospective analysis of Korean data from the Fourth International Study of Mechanical Ventilation. We extracted data of patients under PCV on day 1 and calculated MP using the following simplified equation: MPPCV = 0.098 ∙ respiratory rate ∙ tidal volume ∙ (ΔPinsp + positive end-expiratory pressure), where ΔPinsp is the change in airway pressure during inspiration. Patients were divided into survivors and non-survivors and then compared. Multivariable logistic regression was performed to determine association between MPPCV and ICU mortality. The interaction of MPPCV and use of neuromuscular blocking agent (NMBA) was also analyzed. Results: A total of 125 patients was eligible for final analysis, of whom 38 died in the ICU. MPPCV was higher in non-survivors (17.6 vs. 26.3 J/min, P<0.001). In logistic regression analysis, only MPPCV was significantly associated with ICU mortality (odds ratio, 1.090; 95% confidence interval, 1.029–1.155; P=0.003). There was no significant effect of the interaction between MPPCV and use of NMBA on ICU mortality (P=0.579). Conclusions: MPPCV is associated with ICU mortality in patients mechanically ventilated with PCV mode, regardless of NMBA use.
Liver
Bleeding complications associated with the molecular adsorbent recirculating system: a retrospective study
Seon Woo Yoo, Min-Jong Ki, Dal Kim, Seul Ki Kim, SeungYong Park, Hyo Jin Han, Heung Bum Lee
Acute Crit Care. 2021;36(4):322-331.   Published online November 16, 2021
DOI: https://doi.org/10.4266/acc.2021.00276
  • 4,042 View
  • 95 Download
  • 3 Web of Science
  • 4 Crossref
AbstractAbstract PDF
Background
The molecular adsorbent recirculating system (MARS) is a hepatic replacement system that supports excretory liver function in patients with liver failure. However, since MARS has been employed in our hospital, bleeding complications have occurred in many patients during or after MARS. The objective of this study was to determine how MARS affects coagulopathy and identify specific factors associated with bleeding complications.
Methods
We retrospectively analyzed data from 17 patients undergoing a total of 41 MARS sessions. Complete blood count, coagulation profiles, and blood chemistry values were compared before and after MARS. To identify pre-MARS factors associated with increased bleeding after MARS, we divided patients into bleeder and non-bleeder groups and compared their pre-MARS laboratory values.
Results
MARS significantly reduced bilirubin and creatinine levels. MARS also increased prothrombin time and reduced platelet and fibrinogen, thus negatively impacting coagulation. Pre-MARS hemoglobin was significantly lower in the bleeder group than in the non-bleeder group (P=0.015). When comparing the upper and lower 33% of MARS sessions based on the hemoglobin reduction rate, hemoglobin reduction was significantly greater in MARS sessions involving patients with low pre-MARS international normalized ratio of prothrombin time (PT-INR) and factor V (P=0.038 and P=0.023, respectively).
Conclusions
MARS could appears to alter coagulation-related factors such as factor V and increase the risk of bleeding complications particularly in patient with low hemoglobin. However, individual differences among patients were large, and various factors, such as low hemoglobin, PT-INR, and factor V levels, appear to be involved.

Citations

Citations to this article as recorded by  
  • Fractionated plasma separation and adsorption integrated with continuous veno‐venous hemofiltration in patients with acute liver failure: A single center experience from China
    Jianhua Dong, Li Huang, Chuan Li, Bian Wu, Xi Yang, Yongchun Ge
    Journal of Clinical Apheresis.2024;[Epub]     CrossRef
  • Crosslinked Bifunctional Particles for the Removal of Bilirubin in Hyperbilirubinemia Cases
    María del Prado Garrido, Ana Maria Borreguero, Maria Jesús Ramos, Manuel Carmona, Francisco Javier Redondo Calvo, Juan Francisco Rodriguez
    Materials.2023; 16(8): 2999.     CrossRef
  • The Effect of Molecular Adsorbent Recirculating System in Patients With Liver Failure: A Case Series of 44 Patients
    Shahin Isha, Anna S. Jenkins, Abby J. Hanson, Parthkumar H. Satashia, Sai Abhishek Narra, Gunjan D. Mundhra, Mohammed Mustafa Hasan, Ashrita Donepudi, Abishek Giri, Patrick W. Johnson, Dolores Villar, Christan Santos, Juan Canabal, Philip Lowman, Pablo Mo
    Transplantation Proceedings.2023; 55(9): 2126.     CrossRef
  • Extracorporeal organ support and the kidney
    Maria-Jimena Muciño-Bermejo
    Frontiers in Nephrology.2022;[Epub]     CrossRef
Pediatrics
Characteristics, management and clinical outcomes of patients with sepsis: a multicenter cohort study in Korea
Kyeongman Jeon, Soo Jin Na, Dong Kyu Oh, Sunghoon Park, Eun Young Choi, Seok Chan Kim, Gil Myeong Seong, Jeongwon Heo, Youjin Chang, Won Gun Kwack, Byung Ju Kang, Won-Il Choi, Kyung Chan Kim, So Young Park, Sang Hyun Kwak, Yoon Mi Shin, Heung Bum Lee, So Hee Park, Jae Hwa Cho, Beongki Kim, Chae‐Man Lim
Acute Crit Care. 2019;34(3):179-191.   Published online July 1, 2019
DOI: https://doi.org/10.4266/acc.2019.00514
  • 8,209 View
  • 316 Download
  • 20 Web of Science
  • 22 Crossref
AbstractAbstract PDF
Background
Mortality rates associated with sepsis have increased progressively in Korea, but domestic epidemiologic data remain limited. The objective of this study was to investigate the characteristics, management and clinical outcomes of sepsis patients in Korea.
Methods
This study is a multicenter retrospective cohort study. A total of 64,021 adult patients who visited an emergency department (ED) within one of the 19 participating hospitals during a 1-month period were screened for eligibility. Among these, patients diagnosed with sepsis based on the third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) were included in the study.
Results
Using the Sepsis-3 criteria, 977 sepsis patients were identified, among which 36.5% presented with septic shock. The respiratory system (61.8%) was the most common site of infection. The pathogen involved was identified in 444 patients (45.5%) and multi-drug resistance (MDR) pathogens were isolated in 171 patients. Empiric antibiotic therapy was appropriate in 68.6% of patients, but the appropriateness was significantly reduced in infections associated with MDR pathogens as compared with non-MDR pathogens (58.8% vs. 76.0%, P<0.001). Hospital mortality was 43.2% and 18.5% in sepsis patients with and without shock, respectively. Of the 703 patients who survived to discharge, 61.5% were discharged to home and 38.6% were transferred to other hospitals or facilities.
Conclusions
This study found the prevalence of sepsis in adult patients visiting an ED in Korea was 1.5% (15.2/1,000 patients). Patients with sepsis, especially septic shock, had a high mortality and were often referred to step-down centers after acute and critical care.

Citations

Citations to this article as recorded by  
  • Early Prediction of Mortality for Septic Patients Visiting Emergency Room Based on Explainable Machine Learning: A Real-World Multicenter Study
    Sang Won Park, Na Young Yeo, Seonguk Kang, Taejun Ha, Tae-Hoon Kim, DooHee Lee, Dowon Kim, Seheon Choi, Minkyu Kim, DongHoon Lee, DoHyeon Kim, Woo Jin Kim, Seung-Joon Lee, Yeon-Jeong Heo, Da Hye Moon, Seon-Sook Han, Yoon Kim, Hyun-Soo Choi, Dong Kyu Oh, S
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Deficits in blood culture collection in the emergency department if sepsis is suspected: results of a retrospective cohort study
    Charlotte Berninghausen, Frank Schwab, Alexander Gropmann, Bernd A. Leidel, Rajan Somasundaram, Lydia Hottenbacher, Petra Gastmeier, Sonja Hansen
    Infection.2024;[Epub]     CrossRef
  • Pre-Sepsis Length of Hospital Stay and Mortality: A Nationwide Multicenter Cohort Study
    Joong-Yub Kim, Hong Yeul Lee, Jinwoo Lee, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park, Chae-Man Lim, Sang-Min Lee
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Platelet indices in critically ill septic patients as a predictor of mortality
    Rehab Salah Taha, Mohamed Elsayed Afandy, Abdelaziz Hamid Elbadawi, Mohamed Samir Abd El Ghafar
    Egyptian Journal of Anaesthesia.2023; 39(1): 56.     CrossRef
  • Antibiogram of Multidrug-Resistant Bacteria Based on Sepsis Onset Location in Korea: A Multicenter Cohort Study
    Hyung-Jun Kim, Dong Kyu Oh, Sung Yoon Lim, Young-Jae Cho, Sunghoon Park, Gee Young Suh, Chae-Man Lim, Yeon Joo Lee
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • HYPOTENSION AT THE TIME OF SEPSIS RECOGNITION IS NOT ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS PATIENTS WITH NORMAL LACTATE LEVELS
    Ji Hwan Kim, Yong Kyun Kim, Dong Kyu Oh, Kyeongman Jeon, Ryoung-Eun Ko, Gee Young Suh, Sung Yun Lim, Yeon Joo Lee, Young-Jae Cho, Mi-Hyeon Park, Sang-Bum Hong, Chae-Man Lim, Sunghoon Park
    Shock.2023; 59(3): 360.     CrossRef
  • Mortality among adult patients with sepsis and septic shock in Korea: a systematic review and meta-analysis
    Myeong Namgung, Chiwon Ahn, Yeonkyung Park, Il-Youp Kwak, Jungguk Lee, Moonho Won
    Clinical and Experimental Emergency Medicine.2023; 10(2): 157.     CrossRef
  • Effects of prior antiplatelet and/or nonsteroidal anti-inflammatory drug use on mortality in patients undergoing abdominal surgery for abdominal sepsis
    Se Hun Kim, Ki Hoon Kim
    Surgery.2023; 174(3): 611.     CrossRef
  • Clinical effects of bacteremia in sepsis patients with community-acquired pneumonia
    Tae Wan Kim, Se-Uk Lee, Boram Park, Kyeongman Jeon, Sunghoon Park, Gee Young Suh, Dong Kyu Oh, Soo Yeon Lee, Mi Hyeon Park, Haein Lee, Chae-man Lim, Ryoung-Eun Ko, Sang-Bum Hong, Suk-Kyung Hong, Yeon Joo Lee, Young-Jae Cho, Sung Yoon Lim, Jeongwon Heo, Ja
    BMC Infectious Diseases.2023;[Epub]     CrossRef
  • Current status of treatment of acute respiratory failure in Korea
    Yong Jun Choi, Jae Hwa Cho
    Journal of the Korean Medical Association.2022; 65(3): 124.     CrossRef
  • Clinical Characteristics and Outcomes of Neutropenic Sepsis: A Multicenter Cohort Study
    Soo Jin Na, Dong Kyu Oh, Sunghoon Park, Yeon Joo Lee, Sang-Bum Hong, Mi-Hyun Park, Ryoung-Eun Ko, Chae-Man Lim, Kyeongman Jeon
    Shock.2022; 57(5): 659.     CrossRef
  • Mortality of patients with hospital-onset sepsis in hospitals with all-day and non-all-day rapid response teams: a prospective nationwide multicenter cohort study
    Dong-gon Hyun, Su Yeon Lee, Jee Hwan Ahn, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Chae-Man Lim, Dong Kyu Oh, Gee Young Suh, Kyeongman Jeon, Ryoung-Eun Ko, Young-Jae Cho, Yeon Joo Lee, Sung Yoon Lim, Sunghoon Park, Jeongwon Heo, Jae-myeong Lee, Kyung Cha
    Critical Care.2022;[Epub]     CrossRef
  • Clinical outcomes and prognostic factors of patients with sepsis caused by intra-abdominal infection in the intensive care unit: a post-hoc analysis of a prospective cohort study in Korea
    Chan Hee Park, Jeong Woo Lee, Hak Jae Lee, Dong Kyu Oh, Mi Hyeon Park, Chae-Man Lim, Suk-Kyung Hong, Chae-Man Lim, Sang-Bum Hong, Dong Kyu Oh, Gee Young Suh, Kyeongman Jeon, Ryoung-Eun Ko, Young-Jae Cho, Yeon Joo Lee, Sung Yoon Lim, Sunghoon Park, Chae-Ma
    BMC Infectious Diseases.2022;[Epub]     CrossRef
  • Sepsis in the XXI Century: Etiology, Risk Factors, Epidemiological Features, Complications, Prevention
    L. I. Gomanova, A. Y. Brazhnikov
    Epidemiology and Vaccinal Prevention.2021; 20(3): 107.     CrossRef
  • Characteristics, Management, and Clinical Outcomes of Patients with Hospital-Acquired and Ventilator-Associated Pneumonia: A Multicenter Cohort Study in Korea
    Ryoung-Eun Ko, Kyung Hoon Min, Sang-Bum Hong, Ae-Rin Baek, Hyun-Kyung Lee, Woo Hyun Cho, Changhwan Kim, Youjin Chang, Sung-Soon Lee, Jee Youn Oh, Heung Bum Lee, Soohyun Bae, Jae Young Moon, Kwang Ha Yoo, Kyeongman Jeon
    Tuberculosis and Respiratory Diseases.2021; 84(4): 317.     CrossRef
  • Clinical Usefulness of Red Cell Distribution Width/Albumin Ratio to Discriminate 28-Day Mortality in Critically Ill Patients with Pneumonia Receiving Invasive Mechanical Ventilation, Compared with Lacate/Albumin Ratio: A Retrospective Cohort Study
    Jong Hwan Jeong, Manbong Heo, Seung Jun Lee, Yi Yeong Jeong, Jong Deog Lee, Jung-Wan Yoo
    Diagnostics.2021; 11(12): 2344.     CrossRef
  • Review of 20 Years of Continuous Quality Improvement of a Rapid Response System, at Four Institutions, to Identify Key Process Responsible for Its Success
    Mary Anne Vandegrift, Robert Granata, Vicken Y. Totten, John Kellett, Frank Sebat
    Critical Care Explorations.2021; 3(8): e0448.     CrossRef
  • An Update on Sepsis Biomarkers
    Mi-Hee Kim, Jung-Hyun Choi
    Infection & Chemotherapy.2020; 52(1): 1.     CrossRef
  • Normothermia in Patients With Sepsis Who Present to Emergency Departments Is Associated With Low Compliance With Sepsis Bundles and Increased In-Hospital Mortality Rate*
    Sunghoon Park, Kyeongman Jeon, Dong Kyu Oh, Eun Young Choi, Gil Myeong Seong, Jeongwon Heo, Youjin Chang, Won Gun Kwack, Byung Ju Kang, Won-Il Choi, Kyung Chan Kim, So Young Park, Yoon Mi Shin, Heung Bum Lee, So Hee Park, Seok Chan Kim, Sang Hyun Kwak, Ja
    Critical Care Medicine.2020; 48(10): 1462.     CrossRef
  • Prevention of sepsis in an aging society
    Youngjoon Kang
    Acute and Critical Care.2019; 34(3): 221.     CrossRef
  • Optimal antimicrobial therapy and antimicrobial stewardship in sepsis and septic shock
    Hyeri Seok, Dae Won Park
    Journal of the Korean Medical Association.2019; 62(12): 638.     CrossRef
  • Sepsis
    Yunghee Lee, Young-Jae Cho
    The Korean Journal of Medicine.2019; 94(6): 495.     CrossRef
Review Article
Neurology
Prevention and management of delirium in critically ill adult patients in the intensive care unit: a review based on the 2018 PADIS guidelines
Seung Yong Park, Heung Bum Lee
Acute Crit Care. 2019;34(2):117-125.   Published online April 17, 2019
DOI: https://doi.org/10.4266/acc.2019.00451
  • 21,178 View
  • 1,353 Download
  • 40 Web of Science
  • 41 Crossref
AbstractAbstract PDF
Delirium is an acute, confusional state characterized by altered consciousness and a reduced ability to focus, sustain, or shift attention. It is associated with a number of complex underlying medical conditions and can be difficult to recognize. Many critically ill patients (e.g., up to 80% of patients in the intensive care unit [ICU]) experience delirium due to underlying medical or surgical health problems, recent surgical or other invasive procedures, medications, or various noxious stimuli (e.g., underlying psychological stressors, mechanical ventilation, noise, light, patient care interactions, and drug-induced sleep disruption or deprivation). Delirium is associated with a longer duration of mechanical ventilation and ICU admittance as well as an increased risk of death, disability, and long-term cognitive dysfunction. Therefore, the early recognition of delirium is important and ICU medical staff should devote careful attention to both watching for the occurrence of delirium and its prevention and management. This review presents a brief overview of delirium and an update of the literature with reference to the 2018 Society of Critical Care Medicine Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.

Citations

Citations to this article as recorded by  
  • Precision Anesthesia in 2050
    Frederick H. Kuo, Brant H. Tudor, Geoffrey M. Gray, Luis M. Ahumada, Mohamed A. Rehman, Scott C. Watkins
    Anesthesia & Analgesia.2024; 138(2): 326.     CrossRef
  • Incidence, characteristics and risk factors of delirium in the intensive care unit: An observational study
    Öznur Erbay Dalli, Nermin Kelebek Girgin, Ferda Kahveci
    Journal of Clinical Nursing.2023; 32(1-2): 96.     CrossRef
  • Sustained adherence to a delirium guideline five years after implementation in an intensive care setting: A retrospective cohort study
    Marlies van Bochove-Waardenburg, Mathieu van der Jagt, Janneke de Man-van Ginkel, Erwin Ista
    Intensive and Critical Care Nursing.2023; 76: 103398.     CrossRef
  • Impact of critical care pharmacist‐led interventions on pain, agitation, and delirium in mechanically ventilated adults: A systematic review
    Mitchell S. Buckley, Russel J. Roberts, Melanie J. Yerondopoulos, Audrey K. Bushway, Grace C. Korkames, Sandra L. Kane‐Gill
    JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY.2023; 6(9): 1041.     CrossRef
  • Delirium in the intensive care unit: a narrative review
    Stefania Renzi, Nicola Gitti, Simone Piva
    Journal of Gerontology and Geriatrics.2023; 71(1): 22.     CrossRef
  • Delirio y su relación con la supervivencia en pacientes geriátricos con neumonía grave por SARS-CoV-2 en un hospital de tercer nivel de atención en México
    Cynthia Daniela Bazán Acevedo, Edgar Fernández Muñoz, Netzahualcóyotl González Pérez, Lilia López Carrillo
    Medicina Crítica.2023; 37(1): 35.     CrossRef
  • Effect of using eye masks and earplugs in preventing delirium in intensive care patients: A single‐blinded, randomized, controlled trial
    Gülşen Kiliç, Sultan Kav
    Nursing in Critical Care.2023; 28(5): 698.     CrossRef
  • Yoğun Bakım Deliryumunun Erken Tespitinde Rekalibre PRE-DELIRIC Modelinin Prospektif Değerlendirilmesi
    Öznur ERBAY DALLI, Gülbahar ÇALIŞKAN, Yasemin YILDIRIM, Nermin KELEBEK GİRGİN
    Uludağ Üniversitesi Tıp Fakültesi Dergisi.2023; 49(1): 55.     CrossRef
  • Still WALKing-FOR: 2-year sustainability of the ‘WALK FOR’ intervention
    Efrat Gil, Anna Zisberg, Efrat Shadmi, Nurit Gur-Yaish, Ksenya Shulyaev, Yehudith Chayat, Maayan Agmon
    Age and Ageing.2023;[Epub]     CrossRef
  • Optimization of Care for the Elderly Surgical Emergency Patient
    Rachel Lynne Warner, Nadia Iwanyshyn, Donald Johnson, David J. Skarupa
    Surgical Clinics of North America.2023; 103(6): 1253.     CrossRef
  • Identification and Best Practice Management of Comorbid Geri-Psych Conditions in Critical Care
    Noel Koller-Ditto
    Critical Care Nursing Clinics of North America.2023; 35(4): 481.     CrossRef
  • Inclusion of frailty improved performance of delirium prediction for elderly patients in the cardiac intensive care unit (D-FRAIL): A prospective derivation and external validation study
    Rongrong Guo, Shan Zhang, Saiying Yu, Xiangyu Li, Xinju Liu, Yanling Shen, Jinling Wei, Ying Wu
    International Journal of Nursing Studies.2023; 147: 104582.     CrossRef
  • Motion Detectors as Additional Monitoring Devices in the Intensive Care Unit—A Proof-of-Concept Study
    Gülmisal Güder, Eva von Rein, Thomas Flohr, Dirk Weismann, Dominik Schmitt, Stefan Störk, Stefan Frantz, Vincent Kratzer, Christian Kendi
    Applied Sciences.2023; 13(16): 9319.     CrossRef
  • Analytical Review of Unplanned Extubation in Intensive Care Units and Recommendation on Multidisciplinary Preventive Approaches
    Antonious Anis, Ravi Patel, Maged A Tanios
    Journal of Intensive Care Medicine.2023;[Epub]     CrossRef
  • The risk factors of postoperative cognitive dysfunction in patients undergoing carotid endarterectomy: an updated meta-analysis
    Jinhua He, Ran Duan, Peng Qiu, Huanhuan Zhang, Meng Zhang, Meinv Liu, Xiaoqian Wu, Jianli Li
    Journal of Cardiothoracic Surgery.2023;[Epub]     CrossRef
  • Sedation for Patients with Sepsis: Towards a Personalised Approach
    José Miguel Marcos-Vidal, Rafael González, María Merino, Eva Higuera, Cristina García
    Journal of Personalized Medicine.2023; 13(12): 1641.     CrossRef
  • Le delirium, un syndrome mal connu
    Jean-Pierre Bénézech
    La Revue de l'Infirmière.2022; 71(277): 42.     CrossRef
  • Associations of Smoking With Delirium and Opioid Use in Older Adults With Traumatic Hip Fracture
    Kristin Salottolo, Richard Meinig, Landon Fine, Michael Kelly, Robert Madayag, Francie Ekengren, Allen Tanner, David Bar-Or
    JAAOS: Global Research and Reviews.2022;[Epub]     CrossRef
  • O papel do enfermeiro na prevenção do delirium no paciente adulto/idoso crítico
    Cláudia Oliveira, Cátia Filipa Garnacho Martins Nobre, Rita Margarida Dourado Marques, Maria Manuela Madureira Lebre Mendes, Patrícia Cruz Pontífice Sousa
    Revista Cuidarte.2022;[Epub]     CrossRef
  • Predictors of sedation period for critical illness patients focusing on early rehabilitation on the bed
    Yosuke Morimoto, Tsubasa Watanabe, Masato Oikawa, Masatoshi Hanada, Motohiro Sekino, Tetsuya Hara, Ryo Kozu
    Scientific Reports.2022;[Epub]     CrossRef
  • The Age-adjusted Charlson Comorbidity Index predicts post-operative delirium in the elderly following thoracic and abdominal surgery: A prospective observational cohort study
    Jing Liu, Jianli Li, Jinhua He, Huanhuan Zhang, Meinv Liu, Junfang Rong
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • The Effects of Pain, Agitation, Delirium, Immobility, and Sleep Disruption Education on Novice Nurses in Adult Intensive Care Units
    Szu-Ying Lee, Chieh-Yu Liu, Te-Yu Wu
    Healthcare.2022; 10(8): 1538.     CrossRef
  • Pain Assessment with the BPS and CCPOT Behavioral Pain Scales in Mechanically Ventilated Patients Requiring Analgesia and Sedation
    Katarzyna Wojnar-Gruszka, Aurelia Sega, Lucyna Płaszewska-Żywko, Stanisław Wojtan, Marcelina Potocka, Maria Kózka
    International Journal of Environmental Research and Public Health.2022; 19(17): 10894.     CrossRef
  • Item analysis of the Korean version of the Intensive Care Experience Questionnaire: Using the Rasch Model based on Item Response Theory
    Jiyeon Kang, Minhui Kim
    Journal of Korean Critical Care Nursing.2022; 15(3): 37.     CrossRef
  • Complex Hallucinations in Hospitalized Rehabilitation Patients With COVID-19
    Mari Tobita, Shan-Pin Fanchiang, Aida Saldivar, Sarah Taylor, Barry Jordan
    Archives of Rehabilitation Research and Clinical Translation.2022; 4(4): 100234.     CrossRef
  • Effects of uncomfortable care and histamine H2-antagonists on delirium in acute stroke: A propensity score analysis
    Tomoki Nakamizo, Toshie Kanda, Yosuke Kudo, Eriko Sugawara, Erina Hashimoto, Ayana Okazaki, Makoto Usuda, Toru Nagai, Hiroshi Hara, Ken Johkura
    Journal of the Neurological Sciences.2021; 420: 117251.     CrossRef
  • Critical Care Considerations for Damage Control in a Trauma Patient
    Shannon Gaasch
    AACN Advanced Critical Care.2021; 32(1): 64.     CrossRef
  • Development and Validation of a Clinical Prediction Model for Sleep Disorders in the ICU: A Retrospective Cohort Study
    Yun Li, Lina Zhao, Chenyi Yang, Zhiqiang Yu, Jiannan Song, Qi Zhou, Xizhe Zhang, Jie Gao, Qiang Wang, Haiyun Wang
    Frontiers in Neuroscience.2021;[Epub]     CrossRef
  • Delirium and Associated Length of Stay and Costs in Critically Ill Patients
    Claudia Dziegielewski, Charlenn Skead, Toros Canturk, Colleen Webber, Shannon M. Fernando, Laura H. Thompson, Madison Foster, Vanja Ristovic, Peter G. Lawlor, Dipayan Chaudhuri, Chintan Dave, Brent Herritt, Shirley H. Bush, Salmaan Kanji, Peter Tanuseputr
    Critical Care Research and Practice.2021; 2021: 1.     CrossRef
  • Effects of a simulation‐based education programme on delirium care for critical care nurses: A randomized controlled trial
    Mu‐Hsing Ho, Lee‐Fen Yu, Pu‐Hung Lin, Hui‐Chen (Rita) Chang, Victoria Traynor, Wen‐Cheng Huang, Jed Montayre, Kee‐Hsin Chen
    Journal of Advanced Nursing.2021; 77(8): 3483.     CrossRef
  • A Note on Common Apathy versus Hypoactive Delirium in Critical Illness
    Jan N. M. Schieveld, Jacqueline J. M. H. Strik
    American Journal of Respiratory and Critical Care Medicine.2021; 203(7): 921.     CrossRef
  • Effect of Sedatives on In-hospital and Long-term Mortality of Critically Ill Patients Requiring Extended Mechanical Ventilation for ≥ 48 Hours
    Hannah Lee, Seongmi Choi, Eun Jin Jang, Juhee Lee, Dalho Kim, Seokha Yoo, Seung-Young Oh, Ho Geol Ryu
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Improving delirium detection in intensive care units: Multicomponent education and training program
    Liron Sinvani, Cynthia Delle Site, Tara Laumenede, Vidhi Patel, Suzanne Ardito, Anum Ilyas, Craig Hertz, Gisele Wolf‐Klein, Renee Pekmezaris, Negin Hajizadeh, Lily Thomas
    Journal of the American Geriatrics Society.2021; 69(11): 3249.     CrossRef
  • Delirium in Critical Illness Patients and the Potential Role of Thiamine Therapy in Prevention and Treatment: Findings from a Scoping Review with Implications for Evidence-Based Practice
    Sandra Lange, Wioletta Mędrzycka-Dąbrowska, Adriano Friganovic, Ber Oomen, Sabina Krupa
    International Journal of Environmental Research and Public Health.2021; 18(16): 8809.     CrossRef
  • The Impact of an Attending Intensivist on the Clinical Outcomes of Patients Admitted to the Cardiac Surgical Intensive Care Unit after Coronary Artery Bypass Grafting
    Dong Jung Kim, Bongyeon Sohn, Hakju Kim, Hyoung Woo Chang, Jae Hang Lee, Jun Sung Kim, Cheong Lim, Kay-Hyun Park
    The Korean Journal of Thoracic and Cardiovascular Surgery.2020; 53(1): 8.     CrossRef
  • INCIDENCIA DE DELIRIO SEGÚN EL REGIMEN DE VISITAS EN UNA UNIDAD DE CUIDADOS INTENSIVOS
    Juan Carlos Muñoz Camargo
    Enfermería Intensiva.2020; 31(2): 94.     CrossRef
  • Incidence of delirium according to the visiting regime in an intensive care unit
    J.C. Muñoz Camargo
    Enfermería Intensiva (English ed.).2020; 31(2): 94.     CrossRef
  • The Diagnostic Accuracy of Critical Care Pain Observation Tool (CPOT) in ICU Patients: A Systematic Review and Meta-Analysis
    Yue Zhai, Shining Cai, Yuxia Zhang
    Journal of Pain and Symptom Management.2020; 60(4): 847.     CrossRef
  • Neurologic Manifestations of Systemic Disease: Sleep Disorders
    Eric M. Davis, Chintan Ramani, Mark Quigg
    Current Treatment Options in Neurology.2020;[Epub]     CrossRef
  • Delirium
    Melissa L.P. Mattison
    Annals of Internal Medicine.2020; 173(7): ITC49.     CrossRef
  • Neurological Complications and Noninvasive Multimodal Neuromonitoring in Critically Ill Mechanically Ventilated COVID-19 Patients
    Denise Battaglini, Gregorio Santori, Karthikka Chandraptham, Francesca Iannuzzi, Matilde Bastianello, Fabio Tarantino, Lorenzo Ball, Daniele Roberto Giacobbe, Antonio Vena, Matteo Bassetti, Matilde Inglese, Antonio Uccelli, Patricia Rieken Macedo Rocco, N
    Frontiers in Neurology.2020;[Epub]     CrossRef
Original Article
Infection/Pharmacology
Clinical Effectiveness and Nephrotoxicity of Aerosolized Colistin Treatment in Multidrug-Resistant Gram-Negative Pneumonia
Seung Yong Park, Mi Seon Park, Chi Ryang Chung, Ju Sin Kim, Seoung Ju Park, Heung Bum Lee
Korean J Crit Care Med. 2016;31(3):208-220.   Published online August 30, 2016
DOI: https://doi.org/10.4266/kjccm.2016.00129
  • 13,125 View
  • 285 Download
  • 3 Crossref
AbstractAbstract PDF
Background
Colistin (polymyxin E) is active against multidrug-resistant Gram-negative bacteria (MDR-GNB). However, the effectiveness of inhaled colistin is unclear. This study was designed to assess the effectiveness and safety of aerosolized colistin for the treatment of ventilator-associated pneumonia (VAP) caused by MDR-GNB.
Methods
In this retrospective longitudinal study, we evaluated the medical records of 63 patients who received aerosolized colistin treatment for VAP caused by MDR-GNB in the medical intensive care unit (MICU) from February 2012 to March 2014.
Results
A total of 25 patients with VAP caused by MDR-GNB were included in this study. The negative conversion rate was 84.6% after treatment, and acute kidney injury (AKI) occurred in 11 patients (44%, AKI group). The average length of MICU stay and colistin treatment- related factors, such as daily and total cumulative doses and administration period, were not significantly different between groups. In-hospital mortality tended to be higher in the AKI group (p = 0.07). Multivariate analysis showed that a body mass index less than 18 was an independent risk factor of mortality (odds ratio [OR] = 21.95, 95% confidence interval [CI] 1.59-302.23; p = 0.02). Notably, AKI occurrence was closely related to the administration of more than two nephrotoxic drugs combined with aerosolized colistin (OR = 15.03, 95% CI 1.40-161.76; p = 0.025) and septic shock (OR = 8.10, 95% CI 1.40-161.76; p = 0.04).
Conclusions
The use of adjunctive aerosolized colistin treatment appears to be a relatively safe and effective option for the treatment of VAP caused by MDR-GNB. However, more research on the concomitant use of nephrotoxic drugs with aerosolized colistin will be necessary, as this can be an important risk factor of development of AKI.

Citations

Citations to this article as recorded by  
  • Co-Administration of High-Dose Nebulized Colistin for Acinetobacter baumannii Bacteremic Ventilator-Associated Pneumonia: Impact on Outcomes
    Ioannis Andrianopoulos, Nikolaos Kazakos, Nikolaos Lagos, Theodora Maniatopoulou, Athanasios Papathanasiou, Georgios Papathanakos, Despoina Koulenti, Eleni Toli, Konstantina Gartzonika, Vasilios Koulouras
    Antibiotics.2024; 13(2): 169.     CrossRef
  • Aerosolized antibiotics in the treatment of hospital-acquired pneumonia/ventilator-associated pneumonia
    Yun Jung Jung, Eun Jin Kim, Young Hwa Choi
    The Korean Journal of Internal Medicine.2022; 37(1): 1.     CrossRef
  • Changes in Renal Function by Nebulized Colistimethate Treatment
    Hye Jin Ahn, Yoo Jin Jung, Jae Song Kim, Soo Hyun Kim, Eun Sun Son
    Korean Journal of Clinical Pharmacy.2017; 27(2): 92.     CrossRef
Review
Hormonal Changes in Critical Condition
Heung Bum Lee, Chi Ryang Chung
Korean J Crit Care Med. 2010;25(3):123-129.
DOI: https://doi.org/10.4266/kjccm.2010.25.3.123
  • 2,427 View
  • 29 Download
  • 1 Crossref
AbstractAbstract PDF
When disease or trauma progresses to a critical state, the reaction of the endocrine system in creating homeostasis is essential for survival. The association between the severity of hormonal changes and outcome in terms of morbidity and mortality has led to the challenge of development of several endocrine treatments. During sepsis, nitric oxide-mediated apoptosis is observed in the neurons and glial cells of the cerebrovascular centers of the autonomic nervous system. It is probably one of the components of the circulatory dysfunction of sepsis. The regulation of different organs was neither linear nor independent however organs were found to behave as biological oscillators coupled to each other through neurological or hormonal communication pathways. Sepsis, because of systemic inflammatory responsive syndrome, disrupts these communication pathways and leads to organ failures. Endocrine hormonal issues related to the intensive care setting are common challenges to ICU specialists. Disruptions of the endocrine system in sepsis are characterized by 1) an increase in cortisol plasma levels with a loss of the circadian rhythm of its secretion; 2) hyperglycemia due to insulin resistance and rise in hyperglycemic hormones secretion; 3) relative vasopressin deficiency; and 4) euthyroid sick syndrome or non-thyroidal illness syndrome. This article discusses the dynamic changes of four main endocrine axes: hypothalamic-pituitary-adrenal axis, insulin, vasopressin and thyroid during grave states of disease, when a patient is in critical condition.

Citations

Citations to this article as recorded by  
  • The Changing Pattern of Blood Glucose Levels and Its Association with In-hospital Mortality in the Out-of-hospital Cardiac Arrest Survivors Treated with Therapeutic Hypothermia
    Ki Tae Kim, Byung Kook Lee, Hyoung Youn Lee, Geo Sung Lee, Yong Hun Jung, Kyung Woon Jeung, Hyun Ho Ryu, Byoeng Jo Chun, Jeong Mi Moon
    Korean Journal of Critical Care Medicine.2012; 27(4): 255.     CrossRef

ACC : Acute and Critical Care