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Original Article
- Pulmonary
- Increased red cell distribution width predicts mortality in COVID-19 patients admitted to a Dutch intensive care unit
- Anthony D. Mompiere, Jos L.M.L. le Noble, Manon Fleuren-Janssen, Kelly Broen, Frits van Osch, Norbert Foudraine
- Acute Crit Care. 2024;39(3):359-368. Published online August 22, 2024
- DOI: https://doi.org/10.4266/acc.2023.01137
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- 202 Download
- 3 Web of Science
- 4 Crossref
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Abstract
PDF - Background
Abnormal red blood cell distribution width (RDW) is associated with poor cardiovascular, respiratory, and coronavirus disease 2019 (COVID-19) outcomes. However, whether RDW provides prognostic insights regarding COVID-19 patients admitted to the intensive care unit (ICU) was unknown. Here, we retrospectively investigated the association of RDW with 30-day and 90- day mortalities, duration of mechanical ventilation, and length of ICU and hospital stay in patients with COVID-19.
Methods
This study included 321 patients with COVID-19 aged >18 years who were admitted to the ICU between March 2020 and July 2022. The outcomes were mortality, duration of mechanical ventilation, and length of stay. RDW >14.5% was assessed in blood samples within 24 hours of admission.
Results
The mortality rate was 30.5%. Multivariable Cox regression analysis showed an association between increased RDW and 30-day mortality (hazard ratio [HR], 3.64; 95% CI, 1.54–8.65), 90-day mortality (HR, 3.66; 95% CI, 1.59–8.40), and shorter duration of invasive ventilation (2.7 ventilator-free days, P=0.033).
Conclusions
Increased RDW in COVID-19 patients at ICU admission was associated with increased 30-day and 90-day mortalities, and shorter duration of invasive ventilation. Thus, RDW can be used as a surrogate biomarker for clinical outcomes in COVID-19 patients admitted to the ICU. -
Citations
Citations to this article as recorded by
- Prognostic value and nonlinear association of the rdw/albumin ratio with mortality among COVID-19 patients: a MIMIC-IV database analysis
Ping Huang, Qiuyue Yang, Xintong Wang, Qiqi Lai, Jiannan Zhang, Kai Kang, Mingyan Zhao
BMC Infectious Diseases.2026;[Epub] CrossRef - Red Blood Cell Distribution Width Is Not a Predictor of Hospital Mortality in Elderly and Nonelderly COVID‐19‐Infected Patients: A Prospective Study at a Brazilian Quaternary University Hospital
Helena Duani, Máderson Alvares de Souza Cabral, Carla Jorge Machado, Thalyta Nogueira Fonseca, Milena Soriano Marcolino, Vandack Alencar Nobre, Cecilia Gómez Ravetti, Paula Frizera Vassallo, Unaí Tupinambás, Muhammad Abu Bakr Shabbir
Canadian Journal of Infectious Diseases and Medical Microbiology.2025;[Epub] CrossRef - Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis
Qingzhou Song, Xuanlin Wu, Firooz Ahmad Taheri, Linghou Meng, Wentao Wang, Xianwei Mo
BMC Gastroenterology.2025;[Epub] CrossRef - Association Between Red Cell Distribution Width and Mortality in Patients with Klebsiella pneumoniae Bloodstream Infection: A Cohort Study
Yingxiu Huang, Ting Ao, Ming Hu, Peng Zhen
Infection and Drug Resistance.2025; Volume 18: 5961. CrossRef
- Prognostic value and nonlinear association of the rdw/albumin ratio with mortality among COVID-19 patients: a MIMIC-IV database analysis
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