Skip Navigation
Skip to contents

ACC : Acute and Critical Care

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Issue > Author index
Search
Se Hee Min 1 Article
Infection
Sepsis in Patients Receiving Immunosuppressive Drugs in Korea: Analysis of the National Insurance Database from 2009 to 2013
Seung-Young Oh, Songhee Cho, Hannah Lee, Eun Jin Chang, Se Hee Min, Ho Geol Ryu
Korean J Crit Care Med. 2015;30(4):249-257.   Published online November 30, 2015
DOI: https://doi.org/10.4266/kjccm.2015.30.4.249
  • 7,917 View
  • 186 Download
  • 6 Crossref
AbstractAbstract PDF
Background
The aim of this study is to evaluate the influence of immunosuppressants on in-hospital mortality from sepsis.
Methods
Using data of the Health Insurance Review & Assessment Service, we collected data from patients who were admitted to the hospital due to sepsis from 2009 to 2013. Based on drugs commonly used for immunosuppression caused by various diseases, patients were divided into three groups; immunosuppressant group, steroid-only group, and control group. Patients with no history of immunosuppressants or steroids were assigned to the control group. To identify risk factors of in-hospital mortality in sepsis, we compared differences in patient characteristics, comorbidities, intensive care unit (ICU) care requirements, and immunodeficiency profiles. Subgroup analysis according to age was also performed.
Results
Of the 185,671 included patients, 13,935 (7.5%) were in the steroid-only group and 2,771 patients (1.5%) were in the immunosuppressant group. The overall in-hospital mortality was 38.9% and showed an increasing trend with age. The steroid-only group showed the lowest in-hospital mortality among the three groups except the patients younger than 30 years. The steroid-only group and immunosuppressant group received ICU treatment more frequently (p < 0.001), stayed longer in the hospital (p < 0.001), and showed higher medical expenditure (p < 0.001) compared to the normal group. Univariate and multivariate analyses revealed that age, male gender, comorbidities (especially malignancy), and ICU treatment had a significant effect on in-hospital mortality.
Conclusions
Despite longer hospital length of stay and more frequent need for ICU care, the in-hospital mortality was lower in patients taking immunosuppressive drugs than in patients not taking immunosuppressive drugs.

Citations

Citations to this article as recorded by  
  • Predictive performance of NEWS and qSOFA in immunocompromised sepsis patients at the emergency department
    Lisanne Boekhoud, Helena M. E. A. Schaap, Rick L. Huizinga, Tycho J. Olgers, Jan C. ter Maaten, Douwe F. Postma, Hjalmar R. Bouma
    Infection.2024;[Epub]     CrossRef
  • Effects of Early Initiation of High-Dose Dexamethasone Therapy on Pro-Inflammatory Cytokines and Mortality in LPS-Challenged Mice
    Ji-young Son, Won Gun Kwack, Eun Kyoung Chung, Sooyoung Shin, Yeo Jin Choi
    Healthcare.2022; 10(7): 1247.     CrossRef
  • Alleviation of LPS-Induced Inflammation and Septic Shock by Lactiplantibacillus plantarum K8 Lysates
    Gayoung Kim, Kyeong-Hun Choi, Hangeun Kim, Dae-Kyun Chung
    International Journal of Molecular Sciences.2021; 22(11): 5921.     CrossRef
  • Critical Care Research Using “Big Data”: A Reality in the Near Future
    Kwangha Lee
    Acute and Critical Care.2018; 33(4): 269.     CrossRef
  • Should Very Old Patients Be Admitted to the Intensive Care Units?
    Jun Kwon Cha, In-Ae Song
    The Korean Journal of Critical Care Medicine.2017; 32(4): 376.     CrossRef
  • Sepsis in Immunocompromised Patients: Current Status in Korea
    Kwangha Lee
    The Korean Journal of Critical Care Medicine.2015; 30(4): 239.     CrossRef

ACC : Acute and Critical Care