- Trauma
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The association between the initial lactate level and need for massive transfusion in severe trauma patients with and without traumatic brain injury
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Young Hoon Park, Dong Hyun Ryu, Byung Kook Lee, Dong Hun Lee
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Acute Crit Care. 2019;34(4):255-262. Published online November 29, 2019
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DOI: https://doi.org/10.4266/acc.2019.00640
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 Abstract
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- Background
Exsanguination is a major cause of death in severe trauma patients. The purpose of this study was to analyze the prognostic impact of the initial lactate level for massive transfusion (MT) in severe trauma. We divided patients according to subgroups of traumatic brain injury (TBI) and non-TBI.
Methods
This single-institution retrospective study was conducted on patients who were admitted to hospital for severe trauma between January 2016 and December 2017. TBI was defined by a head Abbreviated Injury Scale ≥3. Receiver operating characteristic analysis was used to analyze the prognostic impact of the lactate level. Multivariate analyses were performed to evaluate the relationship between the MT and lactate level. The primary outcome was MT.
Results
Of the 553 patients, MT was performed in 62 patients (11.2%). The area under the curve (AUC) for the lactate level for predicting MT was 0.779 (95% confidence interval [CI], 0.742 to 0.813). The AUCs for lactate level in the TBI and non-TBI patients were 0.690 (95% CI, 0.627 to 0.747) and 0.842 (95% CI, 0.796 to 0.881), respectively. In multivariate analyses, the lactate level was independently associated with the MT (odds ratio [OR], 1.179; 95% CI, 1.070 to 1.299). The lactate level was independently associated with MT in non-TBI patients (OR, 1.469; 95% CI, 1.262 to 1.710), but not in TBI patients.
Conclusions
The initial lactate level may be a possible prognostic factor for MT in severe trauma. In TBI patients, however, the initial lactate level was not suitable for predicting MT.
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Citations
Citations to this article as recorded by  - Association of initial lactate levels and red blood cell transfusion strategy with outcomes after severe trauma: a post hoc analysis of the RESTRIC trial
Yoshinori Kosaki, Takashi Hongo, Mineji Hayakawa, Daisuke Kudo, Shigeki Kushimoto, Takashi Tagami, Hiromichi Naito, Atsunori Nakao, Tetsuya Yumoto
World Journal of Emergency Surgery.2024;[Epub] CrossRef - Predictors of massive transfusion protocols activation in patients with trauma in Korea: a systematic review
Dongmin Seo, Inhae Heo, Juhong Park, Junsik Kwon, Hye-min Sohn, Kyoungwon Jung
Journal of Trauma and Injury.2024; 37(2): 97. CrossRef - Prehospital Lactate Levels Obtained in the Ambulance and Prediction of 2-Day In-Hospital Mortality in Patients With Traumatic Brain Injury
Francisco Martin-Rodriguez, Ancor Sanz-Garcia, Raul Lopez-Izquierdo, Juan F. Delgado Benito, Francisco T. Martínez Fernández, Santiago Otero de la Torre, Carlos Del Pozo Vegas
Neurology.2024;[Epub] CrossRef - Agreement of point‐of‐care and laboratory lactate levels among trauma patients and association with transfusion
Biswadev Mitra, Madison Essery, Abha Somesh, Carly Talarico, Alexander Olaussen, David Anderson, Benjamin Meadley
Vox Sanguinis.2024;[Epub] CrossRef
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