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Chang-Hoon Lee 2 Articles
Pulmonary
Reduction of PaCO2 by high-flow nasal cannula in acute hypercapnic respiratory failure patients receiving conventional oxygen therapy
Hyun Woo Lee, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee
Acute Crit Care. 2019;34(3):202-211.   Published online August 31, 2019
DOI: https://doi.org/10.4266/acc.2019.00563
  • 10,540 View
  • 221 Download
  • 14 Web of Science
  • 13 Crossref
AbstractAbstract PDF
Background
It has been suggested that a high-flow nasal cannula (HFNC) could help to remove carbon dioxide (CO2) from anatomical dead spaces, but evidence to support that is lacking. The objective of this study was to elucidate whether use of an HFNC could reduce the arterial partial pressure of CO2 (PaCO2) in patients with acute hypercapnic respiratory failure who are receiving conventional oxygen (O2) therapy.
Methods
A propensity score-matched observational study was conducted to evaluate patients treated with an HFNC for acute hypercapnic respiratory failure from 2015 to 2016. The hypercapnia group was defined as patients with a PaCO2 >50 mm Hg and arterial pH <7.35.
Results
Eighteen patients in the hypercapnia group and 177 patients in the nonhypercapnia group were eligible for the present study. Eighteen patients in each group were matched by propensity score. Decreased PaCO2 and consequent pH normalization over time occurred in the hypercapnia group (P=0.002 and P=0.005, respectively). The initial PaCO2 level correlated linearly with PaCO2 removal after the use of an HFNC (R2=0.378, P=0.010). The fraction of inspired O2 used in the intensive care unit was consistently higher for 48 hours in the nonhypercapnia group. Physiological parameters such as respiratory rate and arterial partial pressure of O2 improved over time in both groups.
Conclusions
Physiological parameters can improve after the use of an HFNC in patients with acute hypercapnic respiratory failure given low-flow O2 therapy via a facial mask. Further studies are needed to identify which hypercapnic patients might benefit from an HFNC.

Citations

Citations to this article as recorded by  
  • Efficacy and safety of high-flow nasal cannula therapy in elderly patients with acute respiratory failure
    J.M. Carratalá, S. Diaz-Lobato, B. Brouzet, P. Más-Serrano, J.L.S. Rocamora, A.G. Castro, A.G. Varela, S.M. Alises
    Pulmonology.2024; 30(5): 437.     CrossRef
  • Comparison of preoxygenation with a high-flow nasal cannula and a simple face mask before intubation in patients with head and neck cancer
    Jun-Young Jo, Jungpil Yoon, Heeyoon Jang, Wook-Jong Kim, Seungwoo Ku, Seong-Soo Choi
    Acute and Critical Care.2024; 39(1): 61.     CrossRef
  • Successful noninvasive ventilation in a severely acidotic and hypercapnic comatose COVID-19 patient with multiple comorbidities: a case report
    Joseph Abraham Poonuraparampil, Habib Md Reazaul Karim, Manu P Kesavankutty, Porika Prashanth Nayak
    Acute and Critical Care.2022; 37(1): 120.     CrossRef
  • Comparison of Conventional Oxygen Therapy With High-Flow Nasal Oxygenation in the Management of Hypercapnic Respiratory Failure
    Jitendra Pratap Singh, Deepak Malviya, Samiksha Parashar, Soumya Sankar Nath, Archana Gautam, Neha Shrivastava
    Cureus.2022;[Epub]     CrossRef
  • Current Considerations in Emergency Airway Management
    Andrew Pirotte, Vivek Panchananam, Matthew Finley, Austin Petz, Tom Herrmann
    Current Emergency and Hospital Medicine Reports.2022; 10(4): 73.     CrossRef
  • S/F and ROX indices in predicting failure of high‐flow nasal cannula in children
    Ji Hye Kim, Dong In Suh, June Dong Park
    Pediatrics International.2022;[Epub]     CrossRef
  • Nasal High‐flow Oxygen Versus Conventional Oxygen Therapy for Acute Severe Asthma Patients: A Pilot Randomized Controlled Trial
    Onlak Ruangsomboon, Chok Limsuwat, Nattakarn Praphruetkit, Apichaya Monsomboon, Tipa Chakorn, Brian C. Hiestand
    Academic Emergency Medicine.2021; 28(5): 530.     CrossRef
  • Flow Field Analysis of Adult High‐Flow Nasal Cannula Oxygen Therapy
    Jingen Xia, Jiaqi Chang, Jixiang Liang, Yixuan Wang, Na Wang, Bo Xiao
    Complexity.2021;[Epub]     CrossRef
  • Treatment of Severe Acute on Chronic Liver Failure
    Aarshi Vipani, Christina C. Lindenmeyer, Vinay Sundaram
    Journal of Clinical Gastroenterology.2021; 55(8): 667.     CrossRef
  • Efficacy of High-Flow Nasal Cannula Oxygen Therapy in Patients with Mild Hypercapnia
    Lingling Su, Qinyu Zhao, Taotao Liu, Yujun Xu, Weichun Li, Aiping Zhang
    Lung.2021; 199(5): 447.     CrossRef
  • High-Flow Nasal Cannula Oxygen Therapy Can Be Effective for Patients in Acute Hypoxemic Respiratory Failure with Hypercapnia: a Retrospective, Propensity Score-Matched Cohort Study
    SooHyun Bae, Minkyu Han, Changyoung Kim, Hyeji Lee, Jong-Joon Ahn, Jin Hyoung Kim, Byung Ju Kang
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • High-flow nasal cannula oxygen therapy as an emerging option for respiratory failure: the present and the future
    Lucia Spicuzza, Matteo Schisano
    Therapeutic Advances in Chronic Disease.2020;[Epub]     CrossRef
  • Impact of High-Flow Nasal Cannula on Arterial Blood Gas Parameters in the Emergency Department
    Emre Şancı, Feride Ercan Coşkun, Basak Bayram
    Cureus.2020;[Epub]     CrossRef
Pulmonary/Quality Improvement
Trends in the Use of Intensive Care by Very Elderly Patients and Their Clinical Course in a Single Tertiary Hospital in Korea
Junghyun Kim, Jungkyu Lee, Sunmi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sang-Min Lee
Korean J Crit Care Med. 2016;31(1):25-33.   Published online February 29, 2016
DOI: https://doi.org/10.4266/kjccm.2016.31.1.25
  • 5,827 View
  • 109 Download
  • 2 Crossref
AbstractAbstract PDF
Background:
The number of elderly patients admitted to intensive care units (ICUs) is growing with the increasing proportion of elderly persons in the Korean general population. It is often difficult to make decisions about ICU care for elderly patients, especially when they are in their 90s. Data regarding the proportion of elderly patients in their 90s along with their clinical characteristics in ICU are scarce.
Methods
The records of Korean patients ≥ 90 years old who were admitted to the medical ICU in a tertiary referral hospital between January 2005 and December 2014 were retrospectively reviewed. We compared the trend in ICU use and characteristics of these elderly patients between 2005-2009 and 2010-2014.
Results
Among 6,186 referred patients, 55 aged ≥ 90 years were admitted to the medical ICU from 2005 to 2014. About 58.2% of these patients were male, and their mean age was 92.7 years. Their median Charlson comorbidity index score was 2 (IQR 1-3) and their mean APACHE II score was 25.0 (IQR 19.0-34.0). The most common reason for ICU care was acute respiratory failure. There were no differences in the survival rates between the earlier and more recent cohorts. However, after excluding patients who had specified “do not resuscitate” (DNR), the more recent group showed a significantly higher survival rate (53.8% mortality for the earlier group and 0% mortality for the recent group). Among the survivors, over half were discharged to their homes. More patients in the recent cohort (n=26 [78.8%]) specified DNR than in the earlier cohort (n=7 [35.0%], p=0.004). The number and proportion of patients ≥ 90 years old among patients using ICU during the 2005-2014 study period did not differ.
Conclusions
The use of ICU care by elderly patients ≥ 90 years old was consistent from 2005-2014. The overall mortality rate tended to decrease, but this was not statistically significant. However, the proportion of patients specifying DNR was higher among more recent patients, and the recent group showed an even better survivorship after sensitivity analysis excluded patients specifying DNR.

Citations

Citations to this article as recorded by  
  • Evaluating the effect of age on postoperative and clinical outcomes in patients admitted to the intensive care unit after gastrointestinal cancer surgery
    Jee Yeon Lee, Hyejeong Park, Mi Kyoung Kim, Im-kyung Kim
    Surgery.2022; 172(4): 1270.     CrossRef
  • Characteristics and prognostic factors of very elderly patients admitted to the intensive care unit
    Song-I Lee, Younsuck Koh, Jin Won Huh, Sang-Bum Hong, Chae-Man Lim
    Acute and Critical Care.2022; 37(3): 372.     CrossRef

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